Subclinical inflammation, telomere shortening, homocysteine, vitamin B6, and mortality: the Ludwigshafen Risk and Cardiovascular Health Study

• Published in: European journal of nutrition Vol. 59; no. 4; pp. 1399 - 1411
• Main Authors: Pusceddu, Irene, Herrmann, Wolfgang, Kleber, Marcus E., Scharnagl, Hubert, Hoffmann, Michael M., Winklhofer-Roob, Brigitte M., März, Winfried, Herrmann, Markus
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2020; Springer Nature B.V
• Subjects: Age; C-reactive protein; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - mortality; Chemistry; Chemistry and Materials Science; death; Female; Germany - epidemiology; hazard ratio; Health risk assessment; Health Surveys - methods; Health Surveys - statistics & numerical data; Homocysteine; Homocysteine - blood; Humans; Hyperhomocysteinemia; Inflammation; Inflammation - epidemiology; Interleukin 6; Male; Middle Aged; Mortality; Nutrition; Original Contribution; Oxidative stress; patients; pyridoxine; regression analysis; Risk Assessment; Risk factors; Telomere Shortening; Telomeres; Vitamin B 6 - blood; Vitamin B6; vitamin deficiencies; Vitamin deficiency; Vitamins; Germany; Inflammation; Telomere length; Homocysteine; Mortality; Vitamin B6

Purpose Short telomeres and B vitamin deficiencies have been proposed as risk factors for age-related diseases and mortality that interact through oxidative stress and inflammation. However, available data to support this concept are insufficient. We aimed to investigate the predictive role of B vit...