Periprosthetic UHMWPE Wear Debris Induces Inflammation, Vascularization, and Innervation After Total Disc Replacement in the Lumbar Spine

• Published in: Clinical orthopaedics and related research Vol. 475; no. 5; pp. 1369 - 1381
• Main Authors: Veruva, Sai Y., Lanman, Todd H., Isaza, Jorge E., Freeman, Theresa A., Kurtz, Steven M., Steinbeck, Marla J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2017; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Adult; Biopsy; Conservative Orthopedics; Cytokines - metabolism; Device Removal; Discitis - diagnosis; Discitis - etiology; Discitis - physiopathology; Discitis - surgery; Female; Humans; Immunohistochemistry; Inflammation Mediators - metabolism; Intervertebral Disc - blood supply; Intervertebral Disc - innervation; Intervertebral Disc - metabolism; Intervertebral Disc - surgery; Intervertebral Disc Degeneration - diagnosis; Intervertebral Disc Degeneration - physiopathology; Intervertebral Disc Degeneration - surgery; Low Back Pain - diagnosis; Low Back Pain - etiology; Low Back Pain - physiopathology; Low Back Pain - surgery; Lumbar Vertebrae - blood supply; Lumbar Vertebrae - innervation; Lumbar Vertebrae - metabolism; Lumbar Vertebrae - surgery; Macrophages - metabolism; Male; Medicine; Medicine & Public Health; Middle Aged; Neovascularization, Pathologic; Orthopedics; Pain Measurement; Pain, Postoperative - diagnosis; Pain, Postoperative - etiology; Pain, Postoperative - physiopathology; Pain, Postoperative - surgery; Polyethylenes; Prosthesis Design; Reoperation; Risk Factors; Spine; Sports Medicine; Stress, Mechanical; Substance P - metabolism; Surgery; Surgical Orthopedics; Symposium: Advances in Polyethylene Biomaterials; Time Factors; Total Disc Replacement - adverse effects; Total Disc Replacement - instrumentation; Treatment Outcome; United States; Vascular Endothelial Growth Factor A - metabolism; Young Adult; Vascular Endothelial Growth Factor; Wear Debris; UHMWPE; Nucleus Pulposus; Nerve Growth Factor

Background The pathophysiology and mechanisms driving the generation of unintended pain after total disc replacement (TDR) remain unexplored. Ultrahigh-molecular-weight polyethylene (UHMWPE) wear debris from TDRs is known to induce inflammation, which may result in pain. Questions/purposes The purpo...