Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Hidewaki Nakagawa and colleagues report a genome-wide association study for prostate cancer in a Japanese population. They replicate previously associated loci and identify five new susceptibility loci. Prostate cancer is one of the most common malignancies in males throughout the world 1 , and its...
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| Published in | Nature genetics Vol. 42; no. 9; pp. 751 - 754 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.09.2010
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Hidewaki Nakagawa and colleagues report a genome-wide association study for prostate cancer in a Japanese population. They replicate previously associated loci and identify five new susceptibility loci.
Prostate cancer is one of the most common malignancies in males throughout the world
1
, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at
P
< 1.0 × 10
−7
and ten SNPs at
P
< 0.05 in the Japanese population. The remaining 12 SNPs showed no association (
P
> 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at
5p15
(λ-corrected probability
P
GC
= 3.9 × 10
−18
),
GPRC6A/RFX6
(
P
GC
= 1.6 × 10
−12
),
13q22
(
P
GC
= 2.8 × 10
−9
),
C2orf43
(
P
GC
= 7.5 × 10
−8
) and
FOXP4
(
P
GC
= 7.6 × 10
−8
). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations. |
|---|---|
| AbstractList | Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 10 super(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (l-corrected probability P sub(GC) = 3.9 10 super(-18)), GPRC6A/RFX6 (P sub(GC) = 1.6 10 super(-12)), 13q22 (P sub(GC) = 2.8 10 super(-9)), C2orf43 (P sub(GC) = 7.5 10 super(-8)) and FOXP4 (P sub(GC) = 7.6 10 super(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations. Hidewaki Nakagawa and colleagues report a genome-wide association study for prostate cancer in a Japanese population. They replicate previously associated loci and identify five new susceptibility loci. Prostate cancer is one of the most common malignancies in males throughout the world 1 , and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 × 10 −7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association ( P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ-corrected probability P GC = 3.9 × 10 −18 ), GPRC6A/RFX6 ( P GC = 1.6 × 10 −12 ), 13q22 ( P GC = 2.8 × 10 −9 ), C2orf43 ( P GC = 7.5 × 10 −8 ) and FOXP4 ( P GC = 7.6 × 10 −8 ). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations. Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations. Prostate cancer is one of the most common malignancies in males throughout the world (1), and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x [10.sup.-7] and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ-corrected probability [P.sub.GC] = 3.9 x [10.sup.-18]), GPRC6A/RFX6 ([P.sub.GC] = 1.6 x [10.sup.-12]), 13q22 ([P.sub.GC] = 2.8 x [10.sup.-9]), C2orf43 ([P.sub.GC] = 7.5 x [10.sup.-8]) and FOXP4 ([P.sub.GC] = 7.6 x [10.sup.-8]). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations. Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 x 10(-7) and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association (P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (lambda-corrected probability P(GC) = 3.9 x 10(-18)), GPRC6A/RFX6 (P(GC) = 1.6 x 10(-12)), 13q22 (P(GC) = 2.8 x 10(-9)), C2orf43 (P(GC) = 7.5 x 10(-8)) and FOXP4 (P(GC) = 7.6 x 10(-8)). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations. |
| Audience | Academic |
| Author | Inazawa, Johji Nakagawa, Hidewaki Hosono, Naoya Kamatani, Naoyuki Akamatsu, Shusuke Kubo, Michiaki Takahashi, Atsushi Nakamura, Yusuke Fujioka, Tomoaki Ogawa, Osamu Tsunoda, Tatsuhiko Takata, Ryo Kawaguchi, Takahisa |
| Author_xml | – sequence: 1 givenname: Ryo surname: Takata fullname: Takata, Ryo organization: Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Department of Urology, Iwate Medical University – sequence: 2 givenname: Shusuke surname: Akamatsu fullname: Akamatsu, Shusuke organization: Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN, Department of Urology, Graduate School of Medicine, Kyoto University – sequence: 3 givenname: Michiaki surname: Kubo fullname: Kubo, Michiaki organization: Laboratory for Genotyping Development, Center of Genomic Medicine, RIKEN – sequence: 4 givenname: Atsushi surname: Takahashi fullname: Takahashi, Atsushi organization: Laboratory for Statistical Analysis, Center of Genomic Medicine, RIKEN – sequence: 5 givenname: Naoya surname: Hosono fullname: Hosono, Naoya organization: Laboratory for Genotyping Development, Center of Genomic Medicine, RIKEN – sequence: 6 givenname: Takahisa surname: Kawaguchi fullname: Kawaguchi, Takahisa organization: Laboratory for Medical Informatics, Center of Genomic Medicine, RIKEN – sequence: 7 givenname: Tatsuhiko surname: Tsunoda fullname: Tsunoda, Tatsuhiko organization: Laboratory for Medical Informatics, Center of Genomic Medicine, RIKEN – sequence: 8 givenname: Johji surname: Inazawa fullname: Inazawa, Johji organization: Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University – sequence: 9 givenname: Naoyuki surname: Kamatani fullname: Kamatani, Naoyuki organization: Laboratory for Statistical Analysis, Center of Genomic Medicine, RIKEN – sequence: 10 givenname: Osamu surname: Ogawa fullname: Ogawa, Osamu organization: Department of Urology, Graduate School of Medicine, Kyoto University – sequence: 11 givenname: Tomoaki surname: Fujioka fullname: Fujioka, Tomoaki organization: Department of Urology, Iwate Medical University – sequence: 12 givenname: Yusuke surname: Nakamura fullname: Nakamura, Yusuke organization: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo – sequence: 13 givenname: Hidewaki surname: Nakagawa fullname: Nakagawa, Hidewaki email: hidewaki@ims.u-tokyo.ac.jp organization: Laboratory for Biomarker Development, Center of Genomic Medicine, RIKEN |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23247790$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20676098$$D View this record in MEDLINE/PubMed |
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| Keywords | Urinary system disease Prostate disease Identification Malignant tumor Locus Male genital diseases Prostate cancer Japanese Cancer |
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| Snippet | Hidewaki Nakagawa and colleagues report a genome-wide association study for prostate cancer in a Japanese population. They replicate previously associated loci... Prostate cancer is one of the most common malignancies in males throughout the world, and its incidence is increasing in Asian countries. We carried out a... Prostate cancer is one of the most common malignancies in males throughout the world (1), and its incidence is increasing in Asian countries. We carried out a... |
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| SubjectTerms | 631/208/205/2138 631/208/457 692/699/67/589/466 692/699/67/69 Agriculture Animal Genetics and Genomics Asian Continental Ancestry Group - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Carcinoma - ethnology Carcinoma - genetics Case-Control Studies Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 6 Disease susceptibility Fundamental and applied biological sciences. Psychology Gene Frequency Gene Function Genetic aspects Genetic Loci Genetic Predisposition to Disease - genetics Genetics of eukaryotes. Biological and molecular evolution Genetics, Population Genome-Wide Association Study Gynecology. Andrology. Obstetrics Human Genetics Humans letter Linkage Disequilibrium Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - ethnology Prostatic Neoplasms - genetics Quantitative trait loci Risk factors Tumors Tumors of the urinary system Urinary tract. Prostate gland |
| Title | Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population |
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