Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population

• Published in: Nature genetics Vol. 42; no. 9; pp. 751 - 754
• Main Authors: Takata, Ryo, Akamatsu, Shusuke, Kubo, Michiaki, Takahashi, Atsushi, Hosono, Naoya, Kawaguchi, Takahisa, Tsunoda, Tatsuhiko, Inazawa, Johji, Kamatani, Naoyuki, Ogawa, Osamu, Fujioka, Tomoaki, Nakamura, Yusuke, Nakagawa, Hidewaki
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.09.2010; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/208/457; 692/699/67/589/466; 692/699/67/69; Agriculture; Animal Genetics and Genomics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma - ethnology; Carcinoma - genetics; Case-Control Studies; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 5; Chromosomes, Human, Pair 6; Disease susceptibility; Fundamental and applied biological sciences. Psychology; Gene Frequency; Gene Function; Genetic aspects; Genetic Loci; Genetic Predisposition to Disease - genetics; Genetics of eukaryotes. Biological and molecular evolution; Genetics, Population; Genome-Wide Association Study; Gynecology. Andrology. Obstetrics; Human Genetics; Humans; letter; Linkage Disequilibrium; Male; Male genital diseases; Medical sciences; Nephrology. Urinary tract diseases; Polymorphism, Single Nucleotide; Prostate cancer; Prostatic Neoplasms - ethnology; Prostatic Neoplasms - genetics; Quantitative trait loci; Risk factors; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Japan; Urinary system disease; Prostate disease; Identification; Malignant tumor; Locus; Male genital diseases; Prostate cancer; Japanese; Cancer
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.635

Hidewaki Nakagawa and colleagues report a genome-wide association study for prostate cancer in a Japanese population. They replicate previously associated loci and identify five new susceptibility loci. Prostate cancer is one of the most common malignancies in males throughout the world 1 , and its incidence is increasing in Asian countries. We carried out a genome-wide association study and replication study using 4,584 Japanese men with prostate cancer and 8,801 control subjects. From the thirty-one associated SNPs reported in previous genome-wide association studies in European populations, we confirmed the association of nine SNPs at P < 1.0 × 10 −7 and ten SNPs at P < 0.05 in the Japanese population. The remaining 12 SNPs showed no association ( P > 0.05). In addition, we report here five new loci for prostate cancer susceptibility, at 5p15 (λ-corrected probability P GC = 3.9 × 10 −18 ), GPRC6A/RFX6 ( P GC = 1.6 × 10 −12 ), 13q22 ( P GC = 2.8 × 10 −9 ), C2orf43 ( P GC = 7.5 × 10 −8 ) and FOXP4 ( P GC = 7.6 × 10 −8 ). These findings advance our understanding of the genetic basis of prostate carcinogenesis and also highlight the genetic heterogeneity of prostate cancer susceptibility among different ethnic populations.