In vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma

• Published in: Journal of asthma and allergy Vol. 14; pp. 13 - 22
• Main Authors: Drake, Li Y, Bartemes, Kathleen R, Bachman, Kay A, Hagan, John B, Kita, Hirohito
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2021; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Antibodies; Antigens; Asthma; Cell culture; Cytokines; Enzyme-linked immunosorbent assay; Flow cytometry; il-13; il-25; il-33; il-5; Interleukin 13; Interleukin 2; Interleukin 5; Leukocytes (mononuclear); Lymphoid cells; Mucosa; Original Research; Patients; Peripheral blood mononuclear cells; Population; IL-5; IL-25; IL-13; IL-33

Group 2 innate lymphoid cells (ILC2s) play crucial roles in type 2 immunity and asthma development. While ILC2s are resident in mucosal tissues, they also circulate in peripheral blood. It remains controversial whether ILC2s are increased in the peripheral blood of patients with asthma. The goal of...