(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

• Published in: Neurobiology of disease Vol. 68; pp. 190 - 199
• Main Authors: Chou, Jun-Shiao, Chen, Chu-Yu, Chen, Ying-Ling, Weng, Yi-Hsin, Yeh, Tu-Hsueh, Lu, Chin-Song, Chang, Ya-Ming, Wang, Hung-Li
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2014; Elsevier
• Subjects: (G2019S) LRRK2; (G2019S) LRRK2 transgenic mouse; Animals; Apomorphine - pharmacology; Cerebral Cortex - physiopathology; Corpus Striatum - physiopathology; Corticostriatal long-term depression; Corticostriatal long-term potentiation; Dopamine Agonists - pharmacology; Dopaminergic Neurons - physiology; Evoked dopamine release; GABA Antagonists - pharmacology; Glycine - genetics; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Long-Term Potentiation - drug effects; Long-Term Potentiation - genetics; Mice; Mice, Transgenic; Motor Activity - genetics; Mutation - genetics; Neurology; Parkinson Disease - genetics; Parkinson Disease - pathology; Parkinson Disease - physiopathology; Picrotoxin - pharmacology; Protein-Serine-Threonine Kinases - genetics; Radionuclide Imaging; Serine - genetics; SNpc dopaminergic neurons; Striatal medium spiny neurons; Substantia Nigra - diagnostic imaging; Substantia Nigra - pathology; Tyrosine 3-Monooxygenase - metabolism; (G2019S) LRRK2; Evoked dopamine release; (G2019S) LRRK2 transgenic mouse; Striatal medium spiny neurons; SNpc dopaminergic neurons; Corticostriatal long-term depression; Corticostriatal long-term potentiation

Abstract Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive neuronal death of substantia nigra pars compacta (SNpc) dopaminergic cells. In the present study, we hypothesized that prior to a late-phase death of SNpc dopaminergic neurons, (G2019S) LRRK2 al...