Plasma biomarkers of decreased vesicular storage distinguish Parkinson disease with orthostatic hypotension from the parkinsonian form of multiple system atrophy

• Published in: Clinical autonomic research Vol. 25; no. 1; pp. 61 - 67
• Main Authors: Goldstein, David S., Kopin, Irwin J., Sharabi, Yehonatan, Holmes, Courtney
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.02.2015; Springer Nature B.V
• Subjects: 3,4-Dihydroxyphenylacetic Acid - blood; Aged; Biomarkers - blood; Cardiology; Case-Control Studies; Comorbidity; Cross-Sectional Studies; Diabetes; Diagnosis, Differential; Dopamine - pharmacology; Endocrinology; Female; Fluorine Radioisotopes; Gastroenterology; Humans; Hypotension, Orthostatic - blood; Hypotension, Orthostatic - diagnosis; Male; Medicine; Medicine & Public Health; Methoxyhydroxyphenylglycol - analogs & derivatives; Methoxyhydroxyphenylglycol - blood; Middle Aged; Multiple System Atrophy - blood; Multiple System Atrophy - diagnosis; Neurology; Ophthalmology; Parkinson Disease - blood; Parkinson Disease - diagnosis; Research Article; Sensitivity and Specificity; Synaptic Vesicles - drug effects; Synaptic Vesicles - physiology; Biomarker; Fluorodopamine; Parkinson disease; Multiple system atrophy; Orthostatic hypotension; Sympathetic; Autonomic

Background Parkinson disease with orthostatic hypotension (PD + OH) and the parkinsonian form of multiple system atrophy (MSA-P) can be difficult to distinguish clinically. Recent studies indicate that PD entails a vesicular storage defect in catecholaminergic neurons. Although cardiac sympathetic n...