Leptin reverses weight loss–induced changes in regional neural activity responses to visual food stimuli

• Published in: The Journal of clinical investigation Vol. 118; no. 7; pp. 2583 - 2591
• Main Authors: Rosenbaum, Michael, Sy, Melissa, Pavlovich, Katherine, Leibel, Rudolph L., Hirsch, Joy
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.07.2008
• Subjects: Adult; Appetite Regulation - drug effects; Biomedical research; Body weight; Brain; Brain - drug effects; Brain - physiology; Cerebral Cortex - drug effects; Cerebral Cortex - physiology; Echo-Planar Imaging - methods; Energy; Female; Food; Homeostasis; Humans; Hypothalamus; Hypothalamus - drug effects; Hypothalamus - physiology; Injections, Subcutaneous; Leptin; Leptin - administration & dosage; Leptin - blood; Leptin - pharmacology; Limbic System - drug effects; Limbic System - physiology; Male; Metabolism; Nervous System Physiological Phenomena - drug effects; Obesity; Oxygen - blood; Photic Stimulation - methods; Weight control; Weight loss; Weight Loss - physiology; New York

Increased hunger and food intake during attempts to maintain weight loss are a critical problem in clinical management of obesity. To determine whether reduced body weight maintenance is accompanied by leptin-sensitive changes in neural activity in brain regions affecting regulatory and hedonic aspe...