Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy

Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than c...

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Published inPharmaceutics Vol. 15; no. 10; p. 2490
Main Authors Zong, Rui, Ruan, Hainan, Liu, Chanmin, Fan, Shaohua, Li, Jun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.10.2023
MDPI
Subjects
Bacteria
bacterial components
Bacterial infections
BCG
BCG vaccines
Biocompatibility
biomimetic nanoplatforms
Cancer
Cancer therapies
Clinical trials
Drug delivery systems
E coli
engineered strategies
Fibroblasts
gene therapy
Genetic aspects
Genetic engineering
Gram-positive bacteria
Health aspects
Homeopathy
Hypoxia
Immune system
Lipids
Listeria
Materia medica and therapeutics
Medical research
Metabolites
Metastasis
Nanomaterials
Nanoparticles
Nanotechnology
Permeability
Polyethylene glycol
Proteins
Review
Salmonella
Therapeutics
tumor targeting
Tumors
gene therapy
tumor targeting
bacteria
engineered strategies
bacterial components
biomimetic nanoplatforms
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Abstract Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications.
AbstractList Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications.
Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications.Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications.
Audience Academic
Author Fan, Shaohua
Li, Jun
Zong, Rui
Liu, Chanmin
Ruan, Hainan
AuthorAffiliation School of Life Science, Jiangsu Normal University, Xuzhou 221116, China
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Keywords gene therapy
tumor targeting
bacteria
engineered strategies
bacterial components
biomimetic nanoplatforms
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Snippet Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted...
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SubjectTerms Bacteria
bacterial components
Bacterial infections
BCG
BCG vaccines
Biocompatibility
biomimetic nanoplatforms
Cancer
Cancer therapies
Clinical trials
Drug delivery systems
E coli
engineered strategies
Fibroblasts
gene therapy
Genetic aspects
Genetic engineering
Gram-positive bacteria
Health aspects
Homeopathy
Hypoxia
Immune system
Lipids
Listeria
Materia medica and therapeutics
Medical research
Metabolites
Metastasis
Nanomaterials
Nanoparticles
Nanotechnology
Permeability
Polyethylene glycol
Proteins
Review
Salmonella
Therapeutics
tumor targeting
Tumors
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Title Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy
URI https://www.ncbi.nlm.nih.gov/pubmed/37896250
https://www.proquest.com/docview/2882797406/abstract/
https://www.proquest.com/docview/2883580887/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC10610331
https://doaj.org/article/0a15fbc6d221484b9fadd5473548586b
Volume 15
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