Optimization of screening-level risk assessment and priority selection of emerging pollutants – The case of pharmaceuticals in European surface waters
Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60...
Saved in:
| Published in | Environment international Vol. 128; pp. 1 - 10 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.07.2019
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60% (284) of these compounds belonging to 16 different therapeutic groups were positively detected in one or more of 33 European countries. To conveniently and effectively prioritize potential high-risk compounds, an optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters. The results proved the feasibility and advantages of the optimized method. Pharmaceuticals detected in European surface waters were classified into 5 categories (high, moderate, endurable, negligible and safe) depending on their potential environmental effects and the distribution of pharmaceuticals. Circa 9% (45 out of 477) analyzed compounds showed a potential environmental risk to aquatic ecosystems. Among these 45 compounds, 12 compounds were indicated to have high environmental risk in aquatic environments, while 17 and 7 compounds showed moderate and small-scale environmental risks, respectively.
[Display omitted]
•An optimized method was developed to identify and screen candidate priority pollutants in surface waters.•Different therapeutic groups were positively detected in many European countries.•45 compounds showed potential environmental risks in European surface waters. |
|---|---|
| AbstractList | Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60% (284) of these compounds belonging to 16 different therapeutic groups were positively detected in one or more of 33 European countries. To conveniently and effectively prioritize potential high-risk compounds, an optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters. The results proved the feasibility and advantages of the optimized method. Pharmaceuticals detected in European surface waters were classified into 5 categories (high, moderate, endurable, negligible and safe) depending on their potential environmental effects and the distribution of pharmaceuticals. Circa 9% (45 out of 477) analyzed compounds showed a potential environmental risk to aquatic ecosystems. Among these 45 compounds, 12 compounds were indicated to have high environmental risk in aquatic environments, while 17 and 7 compounds showed moderate and small-scale environmental risks, respectively. Keywords: Pharmaceuticals, Emerging pollutants, Prioritization, Risk assessment Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60% (284) of these compounds belonging to 16 different therapeutic groups were positively detected in one or more of 33 European countries. To conveniently and effectively prioritize potential high-risk compounds, an optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters. The results proved the feasibility and advantages of the optimized method. Pharmaceuticals detected in European surface waters were classified into 5 categories (high, moderate, endurable, negligible and safe) depending on their potential environmental effects and the distribution of pharmaceuticals. Circa 9% (45 out of 477) analyzed compounds showed a potential environmental risk to aquatic ecosystems. Among these 45 compounds, 12 compounds were indicated to have high environmental risk in aquatic environments, while 17 and 7 compounds showed moderate and small-scale environmental risks, respectively.Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60% (284) of these compounds belonging to 16 different therapeutic groups were positively detected in one or more of 33 European countries. To conveniently and effectively prioritize potential high-risk compounds, an optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters. The results proved the feasibility and advantages of the optimized method. Pharmaceuticals detected in European surface waters were classified into 5 categories (high, moderate, endurable, negligible and safe) depending on their potential environmental effects and the distribution of pharmaceuticals. Circa 9% (45 out of 477) analyzed compounds showed a potential environmental risk to aquatic ecosystems. Among these 45 compounds, 12 compounds were indicated to have high environmental risk in aquatic environments, while 17 and 7 compounds showed moderate and small-scale environmental risks, respectively. Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60% (284) of these compounds belonging to 16 different therapeutic groups were positively detected in one or more of 33 European countries. To conveniently and effectively prioritize potential high-risk compounds, an optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters. The results proved the feasibility and advantages of the optimized method. Pharmaceuticals detected in European surface waters were classified into 5 categories (high, moderate, endurable, negligible and safe) depending on their potential environmental effects and the distribution of pharmaceuticals. Circa 9% (45 out of 477) analyzed compounds showed a potential environmental risk to aquatic ecosystems. Among these 45 compounds, 12 compounds were indicated to have high environmental risk in aquatic environments, while 17 and 7 compounds showed moderate and small-scale environmental risks, respectively. Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at present a total of 477 substances (including 66 metabolites and transformation products) have been analyzed in European surface waters. Around 60% (284) of these compounds belonging to 16 different therapeutic groups were positively detected in one or more of 33 European countries. To conveniently and effectively prioritize potential high-risk compounds, an optimized method that considers the frequency of concentrations above predicted no effects levels was developed on the basis of the traditional method, and it was then used to identify and screen candidate priority pollutants in European surface waters. The results proved the feasibility and advantages of the optimized method. Pharmaceuticals detected in European surface waters were classified into 5 categories (high, moderate, endurable, negligible and safe) depending on their potential environmental effects and the distribution of pharmaceuticals. Circa 9% (45 out of 477) analyzed compounds showed a potential environmental risk to aquatic ecosystems. Among these 45 compounds, 12 compounds were indicated to have high environmental risk in aquatic environments, while 17 and 7 compounds showed moderate and small-scale environmental risks, respectively. [Display omitted] •An optimized method was developed to identify and screen candidate priority pollutants in surface waters.•Different therapeutic groups were positively detected in many European countries.•45 compounds showed potential environmental risks in European surface waters. |
| Author | Di Paolo, Carolina Wu, Xinda Hollert, Henner Shao, Ying Zhou, Shangbo Seiler, Thomas-Benjamin |
| Author_xml | – sequence: 1 givenname: Shangbo surname: Zhou fullname: Zhou, Shangbo organization: Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany – sequence: 2 givenname: Carolina orcidid: 0000-0002-4281-1034 surname: Di Paolo fullname: Di Paolo, Carolina organization: Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany – sequence: 3 givenname: Xinda surname: Wu fullname: Wu, Xinda organization: EcoLab (le laboratoire écologie fonctionnelle et environnement), Université Toulouse III - Paul Sabatier, Castanet-Tolosan 31326, France – sequence: 4 givenname: Ying surname: Shao fullname: Shao, Ying organization: Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany – sequence: 5 givenname: Thomas-Benjamin orcidid: 0000-0001-8127-510X surname: Seiler fullname: Seiler, Thomas-Benjamin organization: Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany – sequence: 6 givenname: Henner surname: Hollert fullname: Hollert, Henner email: henner.hollert@bio5.rwth-aachen.de organization: Department of Ecosystem Analysis, ABBt - Aachen Biology and Biotechnology, Institute for Environmental Research, RWTH Aachen University, 52074 Aachen, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31029973$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNks1u1DAUhS1URKeFN0DISzYZ_BcnwwIJVQUqVeqmXVuOcz31kNjBdgaVFe_AhufjSfB0OixYQFeW7O8c3etzTtCRDx4QeknJkhIq32yW4LfO5yUjdLUkYkm4eIIWtG14JZuaHKFFwUglKCPH6CSlDSGEibZ-ho45JWy1avgC_byashvdN51d8DhYnEwE8M6vqwG2MODo0mesU4KURvAZa9_jKboQXb7DCQYwByWMENdFiKcwDHPWPif86_sPfH0L2OgEO2a61XHUBubsjB4Sdh6fzzFMoD1Oc7TlCX_VGWJ6jp7aQsCLh_MU3Xw4vz77VF1efbw4e39ZmbrhuWqNYJ1ZSVOvWNfXtjfCEtq10IlOWyZrKinXne6lNQ0nwA1QW2siuexay4Cfoou9bx_0RpXNRh3vVNBO3V-EuFY6lmkHUMYa0bV1T6HRgjay7TrWG80saziVrS1er_deUwxfZkhZjS4ZGAbtIcxJMcabWoiW149AqWyaXXYFffWAzt0I_Z8ZDyEW4O0eMDGkFMEq4_J9oDlqNyhK1K4xaqP2jVG7xigiVGlMEYu_xAf__8je7WVQstk6iCoZB95A72KpRPk892-D33Bo4bg |
| CitedBy_id | crossref_primary_10_1016_j_jhazmat_2022_129628 crossref_primary_10_1016_j_cej_2021_129216 crossref_primary_10_3390_environments10120198 crossref_primary_10_3390_su14148757 crossref_primary_10_1038_s41598_022_16354_5 crossref_primary_10_1016_j_jhazmat_2023_133054 crossref_primary_10_1016_j_scitotenv_2021_149916 crossref_primary_10_1016_j_psep_2020_03_012 crossref_primary_10_1007_s10008_024_06040_z crossref_primary_10_1016_j_jclepro_2025_144778 crossref_primary_10_1016_j_scitotenv_2022_154532 crossref_primary_10_1039_D4PY01312C crossref_primary_10_1016_j_jhazmat_2022_128302 crossref_primary_10_1002_etc_5520 crossref_primary_10_1016_j_chemosphere_2019_125326 crossref_primary_10_1016_j_scitotenv_2021_146537 crossref_primary_10_1002_etc_5886 crossref_primary_10_1016_j_jenvman_2020_110368 crossref_primary_10_1016_j_watres_2020_116455 crossref_primary_10_1016_j_scitotenv_2022_158247 crossref_primary_10_1016_j_scitotenv_2020_139029 crossref_primary_10_1016_j_jenvman_2022_114609 crossref_primary_10_1021_acs_est_3c08076 crossref_primary_10_1016_j_envint_2022_107263 crossref_primary_10_1016_j_ese_2024_100423 crossref_primary_10_2139_ssrn_4130787 crossref_primary_10_1007_s10646_022_02594_8 crossref_primary_10_1016_j_envpol_2024_125128 crossref_primary_10_1016_j_envpol_2024_124951 crossref_primary_10_1039_D4EM00425F crossref_primary_10_3390_w15030527 crossref_primary_10_1021_acs_est_9b03228 crossref_primary_10_3390_w13131722 crossref_primary_10_1007_s13762_021_03454_4 crossref_primary_10_1007_s00253_020_11032_w crossref_primary_10_1016_j_scitotenv_2020_140043 crossref_primary_10_1016_j_scitotenv_2023_167440 crossref_primary_10_1007_s10653_024_02336_1 crossref_primary_10_3390_toxics12020114 crossref_primary_10_1016_j_heliyon_2023_e18465 crossref_primary_10_18307_2022_0615 crossref_primary_10_1016_j_scitotenv_2024_174388 crossref_primary_10_1016_j_sciaf_2025_e02655 crossref_primary_10_1016_j_scitotenv_2024_177412 crossref_primary_10_1016_j_jece_2022_109012 crossref_primary_10_3233_IDT_240041 crossref_primary_10_1007_s11356_020_10967_x crossref_primary_10_1016_j_seppur_2021_119706 crossref_primary_10_1016_j_aquatox_2023_106455 crossref_primary_10_1016_j_ecoenv_2021_112246 crossref_primary_10_1039_D1RA06607B crossref_primary_10_3389_fmars_2022_1043792 crossref_primary_10_1016_j_scitotenv_2024_171788 crossref_primary_10_1016_j_scitotenv_2023_166581 crossref_primary_10_1139_er_2020_0054 crossref_primary_10_3390_reactions3010012 crossref_primary_10_1016_j_cbpc_2022_109425 crossref_primary_10_1007_s11356_019_07592_8 crossref_primary_10_1016_j_jhazmat_2021_126712 crossref_primary_10_1016_j_jhazmat_2021_127487 crossref_primary_10_1016_j_envres_2020_110152 crossref_primary_10_1002_etc_5278 crossref_primary_10_1186_s12302_024_00855_3 crossref_primary_10_1016_j_matpr_2021_12_229 crossref_primary_10_3390_w15142574 crossref_primary_10_1016_j_chemosphere_2021_132195 crossref_primary_10_1016_j_envres_2020_110278 crossref_primary_10_1016_j_marpolbul_2022_114130 crossref_primary_10_1016_j_jhazmat_2024_133538 crossref_primary_10_1007_s10653_021_00828_y crossref_primary_10_1016_j_envpol_2020_114893 crossref_primary_10_1016_j_enmm_2024_100994 crossref_primary_10_1155_2022_5091181 crossref_primary_10_1016_j_envint_2019_105454 crossref_primary_10_1016_j_jwpe_2023_103490 crossref_primary_10_1016_j_jconhyd_2024_104389 crossref_primary_10_1016_j_algal_2024_103670 crossref_primary_10_5004_dwt_2021_27483 crossref_primary_10_3390_app13053328 crossref_primary_10_1016_j_envres_2021_112061 crossref_primary_10_1016_j_jece_2021_105571 crossref_primary_10_1016_j_scitotenv_2019_135825 crossref_primary_10_1186_s12302_022_00639_7 crossref_primary_10_1002_etc_5046 crossref_primary_10_1016_j_jhazmat_2024_134852 crossref_primary_10_1016_j_jenvman_2023_118705 crossref_primary_10_3390_w13020181 crossref_primary_10_1016_j_envpol_2022_120816 crossref_primary_10_1007_s44274_024_00047_z crossref_primary_10_1007_s11356_020_11799_5 crossref_primary_10_3390_su13031125 crossref_primary_10_1016_j_jece_2023_111024 crossref_primary_10_1016_j_jhazmat_2024_133550 crossref_primary_10_24850_j_tyca_2024_03_07 crossref_primary_10_1016_j_scitotenv_2021_146987 crossref_primary_10_1016_j_scitotenv_2021_145779 crossref_primary_10_1186_s12302_020_00346_1 crossref_primary_10_2139_ssrn_4186674 crossref_primary_10_1016_j_envpol_2023_121638 crossref_primary_10_1016_j_scitotenv_2020_139374 crossref_primary_10_1016_j_ecoenv_2021_112212 crossref_primary_10_1039_D4VA00173G crossref_primary_10_1016_j_scitotenv_2019_136205 crossref_primary_10_1016_j_chemosphere_2022_136370 crossref_primary_10_1016_j_scitotenv_2020_144163 crossref_primary_10_1016_j_envpol_2021_117588 crossref_primary_10_1016_j_scitotenv_2021_150677 crossref_primary_10_1016_j_scitotenv_2023_168680 crossref_primary_10_1016_j_scitotenv_2024_172686 crossref_primary_10_1016_j_chemosphere_2020_128737 crossref_primary_10_1016_j_envpol_2020_115888 crossref_primary_10_1016_j_scitotenv_2024_177217 crossref_primary_10_1016_j_envpol_2020_115405 crossref_primary_10_1002_jctb_7178 crossref_primary_10_1080_10937404_2024_2440876 crossref_primary_10_1016_j_scitotenv_2021_147049 crossref_primary_10_1016_j_seppur_2021_118533 crossref_primary_10_1016_j_scitotenv_2024_174062 crossref_primary_10_1016_j_envpol_2023_122838 crossref_primary_10_3390_ijerph20042967 crossref_primary_10_1002_etc_5062 crossref_primary_10_1016_j_envres_2020_109501 crossref_primary_10_1016_j_chemosphere_2022_135176 crossref_primary_10_1016_j_scitotenv_2023_167594 crossref_primary_10_1007_s11356_023_28421_z crossref_primary_10_1016_j_ecoenv_2023_115024 crossref_primary_10_1007_s11269_024_03982_x crossref_primary_10_1016_j_ecoenv_2023_115149 crossref_primary_10_1016_j_envres_2021_111680 crossref_primary_10_2166_wst_2023_287 crossref_primary_10_1016_j_scitotenv_2023_169806 crossref_primary_10_46555_VTEI_2023_11_002 crossref_primary_10_1002_adfm_202404097 crossref_primary_10_1007_s10924_021_02136_z crossref_primary_10_3390_w17050628 crossref_primary_10_1016_j_scitotenv_2024_173358 crossref_primary_10_1016_j_scitotenv_2024_173596 crossref_primary_10_1016_j_envint_2023_108140 crossref_primary_10_1007_s11356_022_21945_w crossref_primary_10_1016_j_scitotenv_2021_152250 crossref_primary_10_1016_j_jece_2024_113016 crossref_primary_10_3390_w14060950 crossref_primary_10_1016_j_jhazmat_2023_131160 crossref_primary_10_46555_VTEI_2024_05_001 crossref_primary_10_1016_j_chemosphere_2023_139976 crossref_primary_10_1016_j_jenvman_2024_123155 crossref_primary_10_1016_j_watres_2019_05_040 crossref_primary_10_1016_j_ecoenv_2022_114220 crossref_primary_10_1002_wer_1438 crossref_primary_10_46754_umtjur_v5i4_365 crossref_primary_10_1016_j_scitotenv_2024_172358 crossref_primary_10_3389_fenvs_2020_586584 crossref_primary_10_1016_j_scp_2025_101924 crossref_primary_10_1016_j_scitotenv_2020_144918 crossref_primary_10_1007_s11356_024_35274_7 crossref_primary_10_1016_j_scitotenv_2019_136001 crossref_primary_10_1515_zpch_2020_1808 crossref_primary_10_52363_2522_1892_2022_2_9 crossref_primary_10_1016_j_scitotenv_2022_157563 crossref_primary_10_1016_j_envpol_2023_122889 crossref_primary_10_1016_j_jhazmat_2023_131376 crossref_primary_10_1016_j_jhazmat_2024_136348 crossref_primary_10_1016_j_etap_2024_104502 crossref_primary_10_1016_j_scitotenv_2019_07_230 crossref_primary_10_1016_j_scitotenv_2021_150636 crossref_primary_10_3390_membranes12060562 crossref_primary_10_1016_j_scitotenv_2020_144360 crossref_primary_10_1016_j_jece_2022_107803 crossref_primary_10_1016_j_hazadv_2022_100137 crossref_primary_10_1016_j_cep_2023_109563 crossref_primary_10_1016_j_scitotenv_2021_146275 crossref_primary_10_1080_10934529_2022_2117525 crossref_primary_10_1186_s12302_021_00588_7 crossref_primary_10_1016_j_watres_2023_120157 crossref_primary_10_1007_s11244_023_01786_8 crossref_primary_10_1039_D0AY02098B crossref_primary_10_1016_j_scitotenv_2021_146826 crossref_primary_10_1016_j_scitotenv_2022_158302 crossref_primary_10_1071_EN22054 crossref_primary_10_1016_j_scitotenv_2022_157335 crossref_primary_10_1016_j_jhazmat_2022_129214 crossref_primary_10_1016_j_chroma_2023_464554 crossref_primary_10_1016_j_jhazmat_2022_129545 crossref_primary_10_1021_acs_est_2c06319 crossref_primary_10_1016_j_scitotenv_2022_160226 crossref_primary_10_1186_s12302_021_00557_0 crossref_primary_10_1016_j_envpol_2022_120531 crossref_primary_10_1007_s11356_019_07392_0 crossref_primary_10_1016_j_envint_2021_106705 crossref_primary_10_1007_s10646_024_02824_1 crossref_primary_10_1007_s11356_021_18102_0 crossref_primary_10_1016_j_scitotenv_2021_150938 crossref_primary_10_1590_s2179_975x7022 crossref_primary_10_1016_j_scitotenv_2020_141275 crossref_primary_10_1371_journal_pone_0299247 crossref_primary_10_1016_j_scitotenv_2023_163184 crossref_primary_10_1039_C9RA08079A crossref_primary_10_1080_10934529_2022_2104064 crossref_primary_10_1016_j_jece_2021_105966 crossref_primary_10_1016_j_envint_2020_105690 crossref_primary_10_1016_j_envint_2022_107234 crossref_primary_10_1016_j_jhazmat_2023_131362 crossref_primary_10_1016_j_jwpe_2021_102039 crossref_primary_10_1016_j_watres_2020_116017 crossref_primary_10_1016_j_scitotenv_2020_144890 crossref_primary_10_1016_j_envpol_2022_119791 crossref_primary_10_1016_j_rsma_2024_103461 crossref_primary_10_1021_acs_est_3c09120 crossref_primary_10_1016_j_jenvman_2023_118344 crossref_primary_10_1016_j_poly_2022_116082 crossref_primary_10_1016_j_marpolbul_2019_110810 crossref_primary_10_1016_j_cbi_2022_110082 crossref_primary_10_1016_j_hazadv_2022_100172 crossref_primary_10_1016_j_jenvman_2024_122323 crossref_primary_10_1016_j_scitotenv_2021_149730 crossref_primary_10_1007_s11356_022_19583_3 crossref_primary_10_1016_j_jece_2023_110334 crossref_primary_10_1038_s44183_024_00044_y crossref_primary_10_1016_j_jenvman_2020_111030 crossref_primary_10_1016_j_scitotenv_2022_158179 crossref_primary_10_3390_w15081565 crossref_primary_10_1016_j_cej_2024_152666 crossref_primary_10_1016_j_jhazmat_2023_132301 crossref_primary_10_1016_j_chemosphere_2024_142209 crossref_primary_10_1016_j_jelechem_2020_114007 crossref_primary_10_1007_s11356_020_09747_4 crossref_primary_10_3390_ijerph191610246 crossref_primary_10_1016_j_scitotenv_2021_149860 crossref_primary_10_1016_j_jhazmat_2021_126889 crossref_primary_10_1016_j_scitotenv_2020_141718 crossref_primary_10_1016_j_apcato_2024_206919 crossref_primary_10_1007_s10661_022_09751_w crossref_primary_10_1016_j_scitotenv_2022_160379 crossref_primary_10_1016_j_jece_2023_110226 crossref_primary_10_1016_j_jelechem_2024_118454 crossref_primary_10_1007_s11356_021_15249_8 crossref_primary_10_1016_j_scitotenv_2023_164489 crossref_primary_10_3390_molecules28062495 crossref_primary_10_1016_j_scitotenv_2025_178436 crossref_primary_10_1016_j_scitotenv_2022_158622 crossref_primary_10_1016_j_watres_2025_123265 crossref_primary_10_3390_coatings13020381 crossref_primary_10_1007_s11270_023_06844_1 crossref_primary_10_1016_j_scitotenv_2024_171625 crossref_primary_10_1016_j_eng_2023_08_020 |
| Cites_doi | 10.1038/nature02317 10.1016/j.scitotenv.2013.03.043 10.1016/j.scitotenv.2018.04.351 10.1016/j.watres.2016.08.018 10.1016/j.scitotenv.2014.07.022 10.1016/j.scitotenv.2017.06.032 10.1016/j.envpol.2008.09.020 10.1002/etc.501 10.1016/j.watres.2017.07.014 10.1016/j.trac.2018.02.008 10.1016/j.envint.2018.02.013 10.1186/s12302-018-0161-1 10.1016/j.watres.2017.12.044 10.1080/03067319.2012.656099 10.1021/acs.est.5b04083 10.1016/j.scitotenv.2012.08.036 10.1016/j.chemosphere.2010.11.018 10.1007/s00216-006-1033-x 10.1002/etc.3460 10.3389/fnins.2011.00116 10.1016/j.jhazmat.2013.08.040 10.1016/j.yrtph.2003.12.006 10.1016/j.yrtph.2016.05.020 10.1021/acs.est.5b00302 10.1016/j.scitotenv.2016.10.104 10.1021/es1030799 10.1002/etc.3339 10.1186/s12302-017-0112-2 10.1016/j.scitotenv.2014.04.088 10.1021/es9022706 10.1897/04-081R.1 10.1289/ehp.1206446 10.1016/j.envint.2014.05.009 10.1016/j.scitotenv.2011.09.014 10.1016/S0045-6535(99)00453-1 10.1016/j.scitotenv.2011.01.054 10.1016/j.ecoenv.2010.04.011 10.3109/10408440903373590 10.1016/j.trac.2018.02.013 10.1897/08-561.1 10.1016/j.scitotenv.2008.11.059 10.1021/es303013j 10.1073/pnas.0609568104 10.1093/nar/gkv951 10.1002/etc.1879 10.1007/s00216-006-1036-7 10.1016/j.watres.2018.02.066 10.1007/s11356-011-0580-7 10.1007/s10646-012-0956-6 10.1021/es011055j 10.1016/j.watres.2018.04.056 10.1016/j.envint.2013.06.012 10.1080/03601234.2011.540540 10.1007/s10646-008-0209-x 10.1016/j.scitotenv.2017.06.113 |
| ContentType | Journal Article |
| Copyright | 2019 The Authors Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved. |
| Copyright_xml | – notice: 2019 The Authors – notice: Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 7S9 L.6 DOA |
| DOI | 10.1016/j.envint.2019.04.034 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed AGRICOLA |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering Public Health Environmental Sciences |
| EISSN | 1873-6750 |
| EndPage | 10 |
| ExternalDocumentID | oai_doaj_org_article_cfc4b85d1e7a41768bb2dca2f273168f 31029973 10_1016_j_envint_2019_04_034 S0160412018324073 |
| Genre | Journal Article |
| GeographicLocations | Europe |
| GeographicLocations_xml | – name: Europe |
| GroupedDBID | --- --K --M .~1 0R~ 0SF 1B1 1RT 1~. 1~5 29G 4.4 457 4G. 53G 5GY 5VS 6I. 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAFTH AAFWJ AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABEFU ABFNM ABFYP ABJNI ABLST ABMAC ABXDB ABYKQ ACDAQ ACGFS ACRLP ADEZE ADMUD AEBSH AEKER AENEX AFKWA AFPKN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHEUO AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AKIFW ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLECG BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA GROUPED_DOAJ HMC HVGLF HZ~ IHE J1W K-O KCYFY KOM LY9 M41 MO0 N9A NCXOZ O-L O9- OAUVE OK1 OZT P-8 P-9 P2P PC. Q38 R2- RIG RNS ROL RPZ SCC SDF SDG SDP SEN SES SEW SSJ SSZ T5K TN5 WUQ XPP ~02 ~G- AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEGFY AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH NPM 7X8 7S9 EFKBS L.6 |
| ID | FETCH-LOGICAL-c573t-8c42bc96c592bd5fdc4f01b8eb4baf2651613abad6fc730e3ce1f5a0636b8f2e3 |
| IEDL.DBID | DOA |
| ISSN | 0160-4120 1873-6750 |
| IngestDate | Wed Aug 27 01:25:31 EDT 2025 Mon Jul 21 11:15:00 EDT 2025 Fri Jul 11 00:49:26 EDT 2025 Thu Apr 03 07:00:59 EDT 2025 Tue Jul 01 02:37:56 EDT 2025 Thu Apr 24 23:06:11 EDT 2025 Fri Feb 23 02:49:10 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | LOECs NOECs AF QSAR WWTPs Risk assessment Prioritization PNEC MECs Emerging pollutants RQ Pharmaceuticals |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c573t-8c42bc96c592bd5fdc4f01b8eb4baf2651613abad6fc730e3ce1f5a0636b8f2e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8127-510X 0000-0002-4281-1034 |
| OpenAccessLink | https://doaj.org/article/cfc4b85d1e7a41768bb2dca2f273168f |
| PMID | 31029973 |
| PQID | 2216774120 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_cfc4b85d1e7a41768bb2dca2f273168f proquest_miscellaneous_2237544835 proquest_miscellaneous_2216774120 pubmed_primary_31029973 crossref_citationtrail_10_1016_j_envint_2019_04_034 crossref_primary_10_1016_j_envint_2019_04_034 elsevier_sciencedirect_doi_10_1016_j_envint_2019_04_034 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-07-01 |
| PublicationDateYYYYMMDD | 2019-07-01 |
| PublicationDate_xml | – month: 07 year: 2019 text: 2019-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Environment international |
| PublicationTitleAlternate | Environ Int |
| PublicationYear | 2019 |
| Publisher | Elsevier Ltd Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
| References | Cantwell, M.G., Katz, D.R., Sullivan, J.C., Shapley, D., Lipscomb, J., Epstein, J., Juhl, A.R., Knudson, C., O'Mullan, G.D., 2018. Spatial patterns of pharmaceuticals and wastewater tracers in the Hudson River estuary. Water Res. 137, 335–343. Kidd, Blanchfield, Mills, Palace, Evans, Lazorchak, Flick (bb0130) 2007; 104 Triebskorn, Casper, Scheil, Schwaiger (bb0270) 2007; 387 Baker, Kasprzyk-Hordern (bb0025) 2013; 454 Escher, Fenner (bb0095) 2011; 45 Ågerstrand, Berg, Björlenius, Breitholtz, Brunström, Fick, Gunnarsson, Larsson, Sumpter, Tysklind, Rudén (bb0005) 2015; 49 Burns, Carter, Snape, Thomas-oates, Carter (bb0060) 2018; 0 Oaks, Gilbert, Virani, Watson, Meteyer, Rideout, Shivaprasad, Ahmed, Chaudhry, Arshad, Mahmood, Ali, Khan (bb0205) 2004; 427 Corcoran, Winter, Tyler (bb0080) 2010; 40 Park, Choi (bb0215) 2008; 17 von der Ohe, Schmitt-Jansen, Slobodnik, Brack (bb0285) 2012; 19 Stuer-Lauridsen, Birkved, Hansen, Lützhøft, Halling-Sørensen (bb0250) 2000; 40 Ji, Kim, Han, Seo, Lee, Park, Choi, Kho, Kim, Park, Choi (bb0120) 2012; 21 Murata, Takada, Mutoh, Hosoda, Harada, Nakada (bb0195) 2011; 409 EU (bb0100) 2015; 78 SRC (bb0245) 2016 Watkinson, Murby, Kolpin, Costanzo (bb0295) 2009; 407 Ashfaq, Li, Wang, Chen, Wang, Chen, Wu, Huang, Yu, Sun (bb0015) 2017; 123 Kim, Thiessen, Bolton, Chen, Fu, Gindulyte, Han, He, He, Shoemaker, Wang, Yu, Zhang, Bryant (bb0140) 2015; 44 Palma, Köck-Schulmeyer, Alvarenga, Ledo, Barbosa, López de Alda, Barceló (bb0210) 2014; 488 Brooks, Chambliss, Stanley, Ramirez, Banks, Johnson, Lewis (bb0045) 2005; 24 Lahti, Brozinski, Segner, Kronberg, Oikari (bb0160) 2012; 31 Kienzler, Bopp, Linden, Berggren, Worth (bb0135) 2016; 80 Ramirez, A.J., Brain, R.A., Usenko, S., Mottaleb, M.A., O'Donnell, J.G., Stahl, L.L., Wathen, J.B., Snyder, B.D., Pitt, J.L., Perez-Hurtado, P., Dobbins, L.L., Brooks, B.W., Chambliss, C.K., 2009. Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States. Environ. Toxicol. Chem. 28, 2587–2597. Loos, Gawlik, Locoro, Rimaviciute, Contini, Bidoglio (bb0175) 2009; 157 Brack, Dulio, Ågerstrand, Allan, Altenburger, Brinkmann, Bunke, Burgess, Cousins, Escher, Hernández, Hewitt, Hilscherová, Hollender, Hollert, Kase, Klauer, Lindim, López, Miège, Munthe, Toole, Posthuma, Rüdel, Schäfer, Sengl, Smedes, Meent, Brink, Gils, Wezel, Vethaak, Vermeirssen, Ohe, Vrana (bb0030) 2017; 576 Mendoza, Rodríguez-Gil, González-Alonso, Mastroianni, López de Alda, Barceló, Valcárcel (bb0180) 2014; 70 Pruden, Larsson, Amézquita, Collignon, Brandt (bb0225) 2013; 121 Bu, Wang, Huang, Deng, Yu (bb0055) 2013; 262 Houtman, Kroesbergen, Lekkerkerker-Teunissen, van der Hoek (bb0110) 2014; 496 Kolpin, Furlong, Meyer, Thurman, Zaugg, Barber, Buxton (bb0145) 2002; 36 Munthe, Brorström-Lundén, Rahmberg, Posthuma, Altenburger, Brack, Bunke, Engelen, Gawlik, van Gils, Herráez, Rydberg, Slobodnik, van Wezel (bb0190) 2017; 29 Yang, Ying, Zhao, Tao, Su, Liu (bb0300) 2011; 46 Zhang, Wang, Cagnetta, Duan, Yang, Deng, Huang, Wang, Yu (bb0305) 2018; 140 Desbiolles, Malleret, Tiliacos, Wong-Wah-Chung, Laffont-Schwob (bb0085) 2018; 639 Hughes, Kay, Brown (bb0115) 2012; 47 Di Paolo, Ottermanns, Keiter, Ait-Aissa, Bluhm, Brack, Breitholtz, Buchinger, Carere, Chalon, Cousin, Dulio, Escher, Hamers, Hilscherová, Jarque, Jonas, Maillot-Marechal, Marneffe, Nguyen, Pandard, Schifferli, Schulze, Seidensticker, Seiler, Tang, van der Oost, Vermeirssen, Zounková, Zwart, Hollert (bb0090) 2016; 104 Michael, Vasquez, Hapeshi, Haddad, Baginska, Kümmerer, Fatta-Kassinos (bb0185) 2014 Thomatou, Zacharias, Hela, Konstantinou (bb0260) 2013; 93 Tousova, Oswald, Slobodnik, Blaha, Muz, Hu, Brack, Krauss, Di, Tarcai, Seiler, Hollert, Koprivica, Ahel, Schollée, Hollender, Suter, Hidasi, Schirmer, Sonavane, Ait-aissa, Creusot, Brion, Froment, Catarina, Thomas, Erik, Tu, Ouyang, Leonards, Lamoree, Osorio, Kolkman, Schriks, Spirhanzlova, Tindall, Schulze (bb0265) 2017; 602 Schultz, Werner, Schoenfuss, Barber, Blazer, Norris, Vajda (bb0240) 2010; 44 Burns, Carter, Kolpin, Thomas-Oates, Boxall (bb0065) 2018; 137 Busch, Schmidt, Kühne, Schulze, Krauss, Altenburger (bb0070) 2016; 35 Lahti, Brozinski, Jylhä, Kronberg, Oikari (bb0155) 2011; 30 Sanderson, Johnson, Reitsma, Brain, Wilson, Solomon (bb0235) 2004; 39 Vryzas, Alexoudis, Vassiliou, Galanis, Papadopoulou-Mourkidou (bb0290) 2011; 74 Persad (bb0220) 2011; 5 Thomaidi, Matsoukas, Stasinakis (bb0255) 2017; 603 von der Ohe, Dulio, Slobodnik, De Deckere, Kühne, Ebert, Ginebreda, De Cooman, Schüürmann, Brack (bb0280) 2011; 409 Loos, Wollgast, Huber, Hanke (bb0170) 2007; 387 aus der Beek, Weber, Bergmann, Hickmann, Ebert, Hein, Küster (bb0020) 2015; 35 Brausch, Rand (bb0040) 2011; 82 Vazquez-Roig, Andreu, Blasco, Picó (bb0275) 2012; 440 Könemann, Kase, Simon, Swart, Buchinger, Schlüsener, Hollert, Escher, Werner, Aït-Aïssa, Vermeirssen, Dulio, Valsecchi, Polesello, Behnisch, Javurkova, Perceval, Di Paolo, Olbrich, Sychrova, Schlichting, Leborgne, Clara, Scheffknecht, Marneffe, Chalon, Tušil, Soldàn, von Danwitz, Schwaiger, San Martín Becares, Bersani, Hilscherová, Reifferscheid, Ternes, Carere (bb0150) 2018; 102 Kase, Javurkova, Simon, Swart, Buchinger, Könemann, Escher, Carere, Dulio, Ait-Aissa, Hollert, Valsecchi, Polesello, Behnisch, di Paolo, Olbrich, Sychrova, Gundlach, Schlichting, Leborgne, Clara, Scheffknecht, Marneffe, Chalon, Tusil, Soldan, von Danwitz, Schwaiger, Palao, Bersani, Perceval, Kienle, Vermeirssen, Hilscherova, Reifferscheid, Werner (bb0125) 2018; 102 Altenburger, Scholze, Busch, Escher, Jakobs, Krauss, Krüger, Neale, Ait-Aissa, Almeida, Seiler, Brion, Hilscherová, Hollert, Novák, Schlichting, Serra, Shao, Tindall, Tolefsen, Umbuzeiro, Williams, Kortenkamp (bb0010) 2018; 114 Liu, Wong (bb0165) 2013; 59 Neale, Ait-aissa, Brack, Creusot, Denison, Hollert, Krauss, Schulze, Seiler, Serra, Shao, Escher (bb0200) 2015; 49 Brack, Escher, Müller, Schmitt-Jansen, Schulze, Slobodnik, Hollert (bb0035) 2018; 30 Brozinski, Lahti, Meierjohann, Oikari, Kronberg (bb0050) 2012; 47 European Commission (bb0105) 2003 10.1016/j.envint.2019.04.034_bb0075 Brausch (10.1016/j.envint.2019.04.034_bb0040) 2011; 82 EU (10.1016/j.envint.2019.04.034_bb0100) 2015; 78 10.1016/j.envint.2019.04.034_bb0230 Schultz (10.1016/j.envint.2019.04.034_bb0240) 2010; 44 Kolpin (10.1016/j.envint.2019.04.034_bb0145) 2002; 36 Kase (10.1016/j.envint.2019.04.034_bb0125) 2018; 102 Brack (10.1016/j.envint.2019.04.034_bb0035) 2018; 30 SRC (10.1016/j.envint.2019.04.034_bb0245) Yang (10.1016/j.envint.2019.04.034_bb0300) 2011; 46 von der Ohe (10.1016/j.envint.2019.04.034_bb0285) 2012; 19 Vryzas (10.1016/j.envint.2019.04.034_bb0290) 2011; 74 Murata (10.1016/j.envint.2019.04.034_bb0195) 2011; 409 Watkinson (10.1016/j.envint.2019.04.034_bb0295) 2009; 407 Zhang (10.1016/j.envint.2019.04.034_bb0305) 2018; 140 Houtman (10.1016/j.envint.2019.04.034_bb0110) 2014; 496 Kim (10.1016/j.envint.2019.04.034_bb0140) 2015; 44 Mendoza (10.1016/j.envint.2019.04.034_bb0180) 2014; 70 Loos (10.1016/j.envint.2019.04.034_bb0170) 2007; 387 Lahti (10.1016/j.envint.2019.04.034_bb0155) 2011; 30 Desbiolles (10.1016/j.envint.2019.04.034_bb0085) 2018; 639 Brozinski (10.1016/j.envint.2019.04.034_bb0050) 2012; 47 Liu (10.1016/j.envint.2019.04.034_bb0165) 2013; 59 Bu (10.1016/j.envint.2019.04.034_bb0055) 2013; 262 Thomatou (10.1016/j.envint.2019.04.034_bb0260) 2013; 93 Michael (10.1016/j.envint.2019.04.034_bb0185) 2014 Palma (10.1016/j.envint.2019.04.034_bb0210) 2014; 488 Könemann (10.1016/j.envint.2019.04.034_bb0150) 2018; 102 Corcoran (10.1016/j.envint.2019.04.034_bb0080) 2010; 40 Baker (10.1016/j.envint.2019.04.034_bb0025) 2013; 454 Persad (10.1016/j.envint.2019.04.034_bb0220) 2011; 5 Thomaidi (10.1016/j.envint.2019.04.034_bb0255) 2017; 603 aus der Beek (10.1016/j.envint.2019.04.034_bb0020) 2015; 35 Neale (10.1016/j.envint.2019.04.034_bb0200) 2015; 49 Oaks (10.1016/j.envint.2019.04.034_bb0205) 2004; 427 Lahti (10.1016/j.envint.2019.04.034_bb0160) 2012; 31 Di Paolo (10.1016/j.envint.2019.04.034_bb0090) 2016; 104 Ji (10.1016/j.envint.2019.04.034_bb0120) 2012; 21 Stuer-Lauridsen (10.1016/j.envint.2019.04.034_bb0250) 2000; 40 Brooks (10.1016/j.envint.2019.04.034_bb0045) 2005; 24 Busch (10.1016/j.envint.2019.04.034_bb0070) 2016; 35 European Commission (10.1016/j.envint.2019.04.034_bb0105) 2003 Kidd (10.1016/j.envint.2019.04.034_bb0130) 2007; 104 Vazquez-Roig (10.1016/j.envint.2019.04.034_bb0275) 2012; 440 Pruden (10.1016/j.envint.2019.04.034_bb0225) 2013; 121 Hughes (10.1016/j.envint.2019.04.034_bb0115) 2012; 47 Sanderson (10.1016/j.envint.2019.04.034_bb0235) 2004; 39 Brack (10.1016/j.envint.2019.04.034_bb0030) 2017; 576 von der Ohe (10.1016/j.envint.2019.04.034_bb0280) 2011; 409 Burns (10.1016/j.envint.2019.04.034_bb0060) 2018; 0 Ågerstrand (10.1016/j.envint.2019.04.034_bb0005) 2015; 49 Tousova (10.1016/j.envint.2019.04.034_bb0265) 2017; 602 Altenburger (10.1016/j.envint.2019.04.034_bb0010) 2018; 114 Munthe (10.1016/j.envint.2019.04.034_bb0190) 2017; 29 Triebskorn (10.1016/j.envint.2019.04.034_bb0270) 2007; 387 Loos (10.1016/j.envint.2019.04.034_bb0175) 2009; 157 Ashfaq (10.1016/j.envint.2019.04.034_bb0015) 2017; 123 Burns (10.1016/j.envint.2019.04.034_bb0065) 2018; 137 Escher (10.1016/j.envint.2019.04.034_bb0095) 2011; 45 Kienzler (10.1016/j.envint.2019.04.034_bb0135) 2016; 80 Park (10.1016/j.envint.2019.04.034_bb0215) 2008; 17 |
| References_xml | – volume: 409 start-page: 5305 year: 2011 end-page: 5312 ident: bb0195 article-title: Nationwide monitoring of selected antibiotics: distribution and sources of sulfonamides , trimethoprim , and macrolides in Japanese rivers publication-title: Sci. Total Environ. – volume: 603 start-page: 487 year: 2017 end-page: 494 ident: bb0255 article-title: Risk assessment of triclosan released from sewage treatment plants in European rivers using a combination of risk quotient methodology and Monte Carlo simulation publication-title: Sci. Total Environ. – volume: 49 start-page: 5336 year: 2015 end-page: 5345 ident: bb0005 article-title: Improving environmental risk assessment of human pharmaceuticals publication-title: Environ. Sci. Technol. – volume: 29 start-page: 13 year: 2017 ident: bb0190 article-title: An expanded conceptual framework for solution-focused management of chemical pollution in European waters publication-title: Environ. Sci. Eur. – volume: 387 start-page: 1405 year: 2007 end-page: 1416 ident: bb0270 article-title: Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio) publication-title: Anal. Bioanal. Chem. – volume: 31 start-page: 1831−1837 year: 2012 ident: bb0160 article-title: Bioavailability of pharmaceuticals in waters close to wastewater treatment plants−use of bile for exposure assessment publication-title: Environ.Toxicol. Chem. – volume: 39 start-page: 158 year: 2004 end-page: 183 ident: bb0235 article-title: Ranking and prioritization of environmental risks of pharmaceuticals in surface waters publication-title: Regul. Toxicol. Pharmacol. – volume: 74 start-page: 174 year: 2011 end-page: 181 ident: bb0290 article-title: Determination and aquatic risk assessment of pesticide residues in riparian drainage canals in northeastern Greece publication-title: Ecotoxicol. Environ. Saf. – volume: 44 start-page: 1918 year: 2010 end-page: 1925 ident: bb0240 article-title: Antidepressant pharmaceuticals in two US effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue publication-title: Environ. Sci. Technol. – year: 2016 ident: bb0245 article-title: Interactive PhysProp database – volume: 30 start-page: 1403 year: 2011 end-page: 1411 ident: bb0155 article-title: Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout publication-title: Environ. Toxicol. Chem. – volume: 47 start-page: 342 year: 2012 end-page: 348 ident: bb0050 article-title: The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant publication-title: Environ. Sci. Technol. – volume: 93 start-page: 780 year: 2013 end-page: 799 ident: bb0260 article-title: Determination and risk assessment of pesticide residues in lake Amvrakia (W. Greece) after agricultural land use changes in the lake's drainage basin publication-title: Int. J. Environ. Anal. Chem. – volume: 440 start-page: 24 year: 2012 end-page: 32 ident: bb0275 article-title: Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain) publication-title: Sci. Total Environ. – volume: 104 start-page: 8897 year: 2007 end-page: 8901 ident: bb0130 article-title: Collapse of a fish population after exposure to a synthetic estrogen publication-title: Proc. Natl. Acad. Sci. – volume: 19 start-page: 585 year: 2012 end-page: 591 ident: bb0285 article-title: Triclosan—the forgotten priority substance? publication-title: Environ. Sci. Pollut. Res. – volume: 46 start-page: 272 year: 2011 end-page: 280 ident: bb0300 article-title: Spatial and seasonal distribution of selected antibiotics in surface waters of the Pearl Rivers, China publication-title: J. Environ. Sci. Health B – volume: 30 start-page: 33 year: 2018 ident: bb0035 article-title: Towards a holistic and solution-oriented monitoring of chemical status of European water bodies: how to support the EU strategy for a non-toxic environment? publication-title: Environ. Sci. Eur. – volume: 40 start-page: 287 year: 2010 end-page: 304 ident: bb0080 article-title: Pharmaceuticals in the aquatic environment : a critical review of the evidence for health effects in fish publication-title: Crit. Rev. Toxicol. – reference: Ramirez, A.J., Brain, R.A., Usenko, S., Mottaleb, M.A., O'Donnell, J.G., Stahl, L.L., Wathen, J.B., Snyder, B.D., Pitt, J.L., Perez-Hurtado, P., Dobbins, L.L., Brooks, B.W., Chambliss, C.K., 2009. Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States. Environ. Toxicol. Chem. 28, 2587–2597. – volume: 35 start-page: 1887 year: 2016 end-page: 1899 ident: bb0070 article-title: Micropollutants in European rivers: a mode of action survey to support the development of effect-based tools for water monitoring publication-title: Environ. Toxicol. Chem. – volume: 49 start-page: 14614 year: 2015 end-page: 14624 ident: bb0200 article-title: Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling publication-title: Environ. Sci. Technol. – volume: 576 start-page: 720 year: 2017 end-page: 737 ident: bb0030 article-title: Towards the review of the European Union Water Framework Directive: recommendations for more efficient assessment and management of chemical contamination in European surface water resources publication-title: Sci. Total Environ. – volume: 78 start-page: 40 year: 2015 end-page: 42 ident: bb0100 article-title: Decision 495/2015/EU of 20 March 2015 establishing a watch list of substances for union-wide monitoring in the field of water policy pursuant to DirectiveC2008/105/EC of the European Parliament and of the Council publication-title: Off. J. Eur. Union – volume: 102 start-page: 225 year: 2018 end-page: 235 ident: bb0150 article-title: Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive publication-title: TrAC Trends Anal. Chem. – volume: 496 start-page: 54 year: 2014 end-page: 62 ident: bb0110 article-title: Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data publication-title: Sci. Total Environ. – volume: 17 start-page: 526 year: 2008 end-page: 538 ident: bb0215 article-title: Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystems publication-title: Ecotoxicology – volume: 140 start-page: 291 year: 2018 end-page: 300 ident: bb0305 article-title: Typical pharmaceuticals in major WWTPs in Beijing, China: occurrence, load pattern and calculation reliability publication-title: Water Res. – volume: 45 start-page: 3835 year: 2011 end-page: 3847 ident: bb0095 article-title: Recent advances in environmental risk assessment of transformation products publication-title: Environ. Sci. Technol. – volume: 35 start-page: 823 year: 2015 end-page: 835 ident: bb0020 article-title: Pharmaceuticals in the environment - global occurrences and perspectives publication-title: Environ. Toxicol. Chem. – volume: 639 start-page: 1334 year: 2018 end-page: 1348 ident: bb0085 article-title: Occurrence and ecotoxicological assessment of pharmaceuticals: is there a risk for the Mediterranean aquatic environment? publication-title: Sci. Total Environ. – start-page: 413 year: 2014 end-page: 459 ident: bb0185 article-title: Metabolites and transformation products of pharmaceuticals in the aquatic environment as contaminants of emerging concern publication-title: Transformation Products of Emerging Contaminants in the Environment – volume: 407 start-page: 2711 year: 2009 end-page: 2723 ident: bb0295 article-title: The occurrence of antibiotics in an urban watershed: from wastewater to drinking water publication-title: Sci. Total Environ. – volume: 40 start-page: 783 year: 2000 end-page: 793 ident: bb0250 article-title: Environmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use publication-title: Chemosphere – volume: 114 start-page: 95 year: 2018 end-page: 106 ident: bb0010 article-title: Mixture effects in samples of multiple contaminants – an inter-laboratory study with manifold bioassays publication-title: Environ. Int. – volume: 59 start-page: 208 year: 2013 end-page: 224 ident: bb0165 article-title: Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China publication-title: Environ. Int. – volume: 44 start-page: D1202 year: 2015 end-page: D1213 ident: bb0140 article-title: PubChem substance and compound databases publication-title: Nucleic Acids Res. – volume: 602 start-page: 1849 year: 2017 end-page: 1868 ident: bb0265 article-title: European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters publication-title: Sci. Total Environ. – volume: 409 start-page: 2064 year: 2011 end-page: 2077 ident: bb0280 article-title: A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European Water Framework Directive publication-title: Sci. Total Environ. – reference: Cantwell, M.G., Katz, D.R., Sullivan, J.C., Shapley, D., Lipscomb, J., Epstein, J., Juhl, A.R., Knudson, C., O'Mullan, G.D., 2018. Spatial patterns of pharmaceuticals and wastewater tracers in the Hudson River estuary. Water Res. 137, 335–343. – volume: 454 start-page: 442 year: 2013 end-page: 456 ident: bb0025 article-title: Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: new developments publication-title: Sci. Total Environ. – volume: 262 start-page: 189 year: 2013 end-page: 211 ident: bb0055 article-title: Pharmaceuticals and personal care products in the aquatic environment in China: a review publication-title: J. Hazard. Mater. – volume: 82 start-page: 1518 year: 2011 end-page: 1532 ident: bb0040 article-title: A review of personal care products in the aquatic environment: environmental concentrations and toxicity publication-title: Chemosphere – volume: 24 start-page: 464−469 year: 2005 ident: bb0045 article-title: Determination of select antidepressants in fish from an effluent-dominated stream publication-title: Environ. Toxicol. Chem. – volume: 21 start-page: 2031 year: 2012 end-page: 2050 ident: bb0120 article-title: Risk assessment of chlortetracycline, oxytetracycline, sulfamethazine, sulfathiazole, and erythromycin in aquatic environment: are the current environmental concentrations safe? publication-title: Ecotoxicology – volume: 0 start-page: 1 year: 2018 end-page: 27 ident: bb0060 article-title: Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticals and testing of pharmaceuticals publication-title: J. Toxicol. Environ. Health, Part B – volume: 123 start-page: 655 year: 2017 end-page: 667 ident: bb0015 article-title: Occurrence, fate, and mass balance of different classes of pharmaceuticals and personal care products in an anaerobic-anoxic-oxic wastewater treatment plant in Xiamen, China publication-title: Water Res. – volume: 387 start-page: 1469 year: 2007 end-page: 1478 ident: bb0170 article-title: Polar herbicides, pharmaceutical products, perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and nonylphenol and its carboxylates and ethoxylates in surface and tap waters around Lake Maggiore in Northern Italy publication-title: Anal. Bioanal. Chem. – volume: 121 start-page: 878 year: 2013 end-page: 885 ident: bb0225 article-title: Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment publication-title: Environ. Health Perspect. – volume: 5 start-page: 1 year: 2011 end-page: 8 ident: bb0220 article-title: Energy drinks and the neurophysiological impact of caffeine publication-title: Front. Neurosci. – volume: 80 start-page: 321 year: 2016 end-page: 334 ident: bb0135 article-title: Regulatory assessment of chemical mixtures: requirements , current approaches and future perspectives publication-title: Regul. Toxicol. Pharmacol. – volume: 427 start-page: 630 year: 2004 end-page: 633 ident: bb0205 article-title: Diclofenac residues as the cause of vulture population decline in Pakistan publication-title: Nature – volume: 104 start-page: 473 year: 2016 end-page: 484 ident: bb0090 article-title: Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts – towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring publication-title: Water Res. – volume: 137 start-page: 72 year: 2018 end-page: 85 ident: bb0065 article-title: Temporal and spatial variation in pharmaceutical concentrations in an urban river system publication-title: Water Res. – volume: 47 start-page: 661−677 year: 2012 ident: bb0115 article-title: A global synthesis and critical evaluation of pharmaceutical datasets collected from river systems publication-title: Environ. Sci. Technol. – volume: 36 start-page: 1202 year: 2002 end-page: 1211 ident: bb0145 article-title: Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999−2000: a national reconnaissance publication-title: Environ. Sci. Technol. – start-page: 7 year: 2003 end-page: 179 ident: bb0105 article-title: Technical Guidance Document on Risk Assessment in Support of Commission Directive 93/67/ EEC on Risk Assessment for New Notified Substances and Commission Regulation (EC) No. 1488/94 on Risk Assessment for Existing Substances. Part II. EUR 20418 EN/2. European Chemicals Bureau Part II – volume: 488 start-page: 208 year: 2014 end-page: 219 ident: bb0210 article-title: Risk assessment of pesticides detected in surface water of the Alqueva reservoir (Guadiana basin, southern of Portugal) publication-title: Sci. Total Environ. – volume: 157 start-page: 561 year: 2009 end-page: 568 ident: bb0175 article-title: EU-wide survey of polar organic persistent pollutants in European river waters publication-title: Environ. Pollut. – volume: 70 start-page: 76 year: 2014 end-page: 87 ident: bb0180 article-title: Drugs of abuse and benzodiazepines in the Madrid Region (Central Spain): seasonal variation in river waters, occurrence in tap water and potential environmental and human risk publication-title: Environ. Int. – volume: 102 start-page: 343 year: 2018 end-page: 358 ident: bb0125 article-title: Screening and risk management solutions for steroidal estrogens in surface and wastewater publication-title: TrAC Trends Anal. Chem. – volume: 427 start-page: 630 year: 2004 ident: 10.1016/j.envint.2019.04.034_bb0205 article-title: Diclofenac residues as the cause of vulture population decline in Pakistan publication-title: Nature doi: 10.1038/nature02317 – volume: 454 start-page: 442 year: 2013 ident: 10.1016/j.envint.2019.04.034_bb0025 article-title: Spatial and temporal occurrence of pharmaceuticals and illicit drugs in the aqueous environment and during wastewater treatment: new developments publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2013.03.043 – volume: 639 start-page: 1334 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0085 article-title: Occurrence and ecotoxicological assessment of pharmaceuticals: is there a risk for the Mediterranean aquatic environment? publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2018.04.351 – volume: 104 start-page: 473 year: 2016 ident: 10.1016/j.envint.2019.04.034_bb0090 article-title: Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts – towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring publication-title: Water Res. doi: 10.1016/j.watres.2016.08.018 – volume: 496 start-page: 54 year: 2014 ident: 10.1016/j.envint.2019.04.034_bb0110 article-title: Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2014.07.022 – volume: 602 start-page: 1849 year: 2017 ident: 10.1016/j.envint.2019.04.034_bb0265 article-title: European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2017.06.032 – volume: 157 start-page: 561 year: 2009 ident: 10.1016/j.envint.2019.04.034_bb0175 article-title: EU-wide survey of polar organic persistent pollutants in European river waters publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2008.09.020 – volume: 30 start-page: 1403 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0155 article-title: Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout publication-title: Environ. Toxicol. Chem. doi: 10.1002/etc.501 – volume: 123 start-page: 655 year: 2017 ident: 10.1016/j.envint.2019.04.034_bb0015 article-title: Occurrence, fate, and mass balance of different classes of pharmaceuticals and personal care products in an anaerobic-anoxic-oxic wastewater treatment plant in Xiamen, China publication-title: Water Res. doi: 10.1016/j.watres.2017.07.014 – volume: 102 start-page: 225 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0150 article-title: Effect-based and chemical analytical methods to monitor estrogens under the European Water Framework Directive publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2018.02.008 – volume: 114 start-page: 95 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0010 article-title: Mixture effects in samples of multiple contaminants – an inter-laboratory study with manifold bioassays publication-title: Environ. Int. doi: 10.1016/j.envint.2018.02.013 – volume: 30 start-page: 33 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0035 article-title: Towards a holistic and solution-oriented monitoring of chemical status of European water bodies: how to support the EU strategy for a non-toxic environment? publication-title: Environ. Sci. Eur. doi: 10.1186/s12302-018-0161-1 – ident: 10.1016/j.envint.2019.04.034_bb0075 doi: 10.1016/j.watres.2017.12.044 – volume: 93 start-page: 780 year: 2013 ident: 10.1016/j.envint.2019.04.034_bb0260 article-title: Determination and risk assessment of pesticide residues in lake Amvrakia (W. Greece) after agricultural land use changes in the lake's drainage basin publication-title: Int. J. Environ. Anal. Chem. doi: 10.1080/03067319.2012.656099 – volume: 49 start-page: 14614 year: 2015 ident: 10.1016/j.envint.2019.04.034_bb0200 article-title: Linking in vitro effects and detected organic micropollutants in surface water using mixture-toxicity modeling publication-title: Environ. Sci. Technol. doi: 10.1021/acs.est.5b04083 – volume: 440 start-page: 24 year: 2012 ident: 10.1016/j.envint.2019.04.034_bb0275 article-title: Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain) publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2012.08.036 – volume: 82 start-page: 1518 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0040 article-title: A review of personal care products in the aquatic environment: environmental concentrations and toxicity publication-title: Chemosphere doi: 10.1016/j.chemosphere.2010.11.018 – volume: 387 start-page: 1405 year: 2007 ident: 10.1016/j.envint.2019.04.034_bb0270 article-title: Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio) publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-006-1033-x – volume: 0 start-page: 1 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0060 article-title: Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticals and testing of pharmaceuticals publication-title: J. Toxicol. Environ. Health, Part B – volume: 35 start-page: 1887 year: 2016 ident: 10.1016/j.envint.2019.04.034_bb0070 article-title: Micropollutants in European rivers: a mode of action survey to support the development of effect-based tools for water monitoring publication-title: Environ. Toxicol. Chem. doi: 10.1002/etc.3460 – volume: 5 start-page: 1 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0220 article-title: Energy drinks and the neurophysiological impact of caffeine publication-title: Front. Neurosci. doi: 10.3389/fnins.2011.00116 – volume: 262 start-page: 189 year: 2013 ident: 10.1016/j.envint.2019.04.034_bb0055 article-title: Pharmaceuticals and personal care products in the aquatic environment in China: a review publication-title: J. Hazard. Mater. doi: 10.1016/j.jhazmat.2013.08.040 – volume: 39 start-page: 158 year: 2004 ident: 10.1016/j.envint.2019.04.034_bb0235 article-title: Ranking and prioritization of environmental risks of pharmaceuticals in surface waters publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2003.12.006 – volume: 80 start-page: 321 year: 2016 ident: 10.1016/j.envint.2019.04.034_bb0135 article-title: Regulatory assessment of chemical mixtures: requirements , current approaches and future perspectives publication-title: Regul. Toxicol. Pharmacol. doi: 10.1016/j.yrtph.2016.05.020 – start-page: 413 year: 2014 ident: 10.1016/j.envint.2019.04.034_bb0185 article-title: Metabolites and transformation products of pharmaceuticals in the aquatic environment as contaminants of emerging concern – ident: 10.1016/j.envint.2019.04.034_bb0245 – volume: 49 start-page: 5336 year: 2015 ident: 10.1016/j.envint.2019.04.034_bb0005 article-title: Improving environmental risk assessment of human pharmaceuticals publication-title: Environ. Sci. Technol. doi: 10.1021/acs.est.5b00302 – volume: 576 start-page: 720 year: 2017 ident: 10.1016/j.envint.2019.04.034_bb0030 article-title: Towards the review of the European Union Water Framework Directive: recommendations for more efficient assessment and management of chemical contamination in European surface water resources publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2016.10.104 – volume: 45 start-page: 3835 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0095 article-title: Recent advances in environmental risk assessment of transformation products publication-title: Environ. Sci. Technol. doi: 10.1021/es1030799 – volume: 78 start-page: 40 year: 2015 ident: 10.1016/j.envint.2019.04.034_bb0100 article-title: Decision 495/2015/EU of 20 March 2015 establishing a watch list of substances for union-wide monitoring in the field of water policy pursuant to DirectiveC2008/105/EC of the European Parliament and of the Council publication-title: Off. J. Eur. Union – volume: 35 start-page: 823 year: 2015 ident: 10.1016/j.envint.2019.04.034_bb0020 article-title: Pharmaceuticals in the environment - global occurrences and perspectives publication-title: Environ. Toxicol. Chem. doi: 10.1002/etc.3339 – volume: 47 start-page: 661−677 year: 2012 ident: 10.1016/j.envint.2019.04.034_bb0115 article-title: A global synthesis and critical evaluation of pharmaceutical datasets collected from river systems publication-title: Environ. Sci. Technol. – volume: 29 start-page: 13 year: 2017 ident: 10.1016/j.envint.2019.04.034_bb0190 article-title: An expanded conceptual framework for solution-focused management of chemical pollution in European waters publication-title: Environ. Sci. Eur. doi: 10.1186/s12302-017-0112-2 – volume: 488 start-page: 208 year: 2014 ident: 10.1016/j.envint.2019.04.034_bb0210 article-title: Risk assessment of pesticides detected in surface water of the Alqueva reservoir (Guadiana basin, southern of Portugal) publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2014.04.088 – volume: 44 start-page: 1918 year: 2010 ident: 10.1016/j.envint.2019.04.034_bb0240 article-title: Antidepressant pharmaceuticals in two US effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue publication-title: Environ. Sci. Technol. doi: 10.1021/es9022706 – volume: 24 start-page: 464−469 year: 2005 ident: 10.1016/j.envint.2019.04.034_bb0045 article-title: Determination of select antidepressants in fish from an effluent-dominated stream publication-title: Environ. Toxicol. Chem. doi: 10.1897/04-081R.1 – volume: 121 start-page: 878 year: 2013 ident: 10.1016/j.envint.2019.04.034_bb0225 article-title: Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1206446 – volume: 70 start-page: 76 year: 2014 ident: 10.1016/j.envint.2019.04.034_bb0180 article-title: Drugs of abuse and benzodiazepines in the Madrid Region (Central Spain): seasonal variation in river waters, occurrence in tap water and potential environmental and human risk publication-title: Environ. Int. doi: 10.1016/j.envint.2014.05.009 – volume: 409 start-page: 5305 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0195 article-title: Nationwide monitoring of selected antibiotics: distribution and sources of sulfonamides , trimethoprim , and macrolides in Japanese rivers publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2011.09.014 – volume: 40 start-page: 783 year: 2000 ident: 10.1016/j.envint.2019.04.034_bb0250 article-title: Environmental risk assessment of human pharmaceuticals in Denmark after normal therapeutic use publication-title: Chemosphere doi: 10.1016/S0045-6535(99)00453-1 – volume: 409 start-page: 2064 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0280 article-title: A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European Water Framework Directive publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2011.01.054 – volume: 74 start-page: 174 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0290 article-title: Determination and aquatic risk assessment of pesticide residues in riparian drainage canals in northeastern Greece publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2010.04.011 – volume: 40 start-page: 287 year: 2010 ident: 10.1016/j.envint.2019.04.034_bb0080 article-title: Pharmaceuticals in the aquatic environment : a critical review of the evidence for health effects in fish publication-title: Crit. Rev. Toxicol. doi: 10.3109/10408440903373590 – volume: 102 start-page: 343 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0125 article-title: Screening and risk management solutions for steroidal estrogens in surface and wastewater publication-title: TrAC Trends Anal. Chem. doi: 10.1016/j.trac.2018.02.013 – ident: 10.1016/j.envint.2019.04.034_bb0230 doi: 10.1897/08-561.1 – start-page: 7 year: 2003 ident: 10.1016/j.envint.2019.04.034_bb0105 – volume: 407 start-page: 2711 year: 2009 ident: 10.1016/j.envint.2019.04.034_bb0295 article-title: The occurrence of antibiotics in an urban watershed: from wastewater to drinking water publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2008.11.059 – volume: 47 start-page: 342 year: 2012 ident: 10.1016/j.envint.2019.04.034_bb0050 article-title: The anti-inflammatory drugs diclofenac, naproxen and ibuprofen are found in the bile of wild fish caught downstream of a wastewater treatment plant publication-title: Environ. Sci. Technol. doi: 10.1021/es303013j – volume: 104 start-page: 8897 year: 2007 ident: 10.1016/j.envint.2019.04.034_bb0130 article-title: Collapse of a fish population after exposure to a synthetic estrogen publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.0609568104 – volume: 44 start-page: D1202 issue: D1 year: 2015 ident: 10.1016/j.envint.2019.04.034_bb0140 article-title: PubChem substance and compound databases publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv951 – volume: 31 start-page: 1831−1837 year: 2012 ident: 10.1016/j.envint.2019.04.034_bb0160 article-title: Bioavailability of pharmaceuticals in waters close to wastewater treatment plants−use of bile for exposure assessment publication-title: Environ.Toxicol. Chem. doi: 10.1002/etc.1879 – volume: 387 start-page: 1469 year: 2007 ident: 10.1016/j.envint.2019.04.034_bb0170 article-title: Polar herbicides, pharmaceutical products, perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and nonylphenol and its carboxylates and ethoxylates in surface and tap waters around Lake Maggiore in Northern Italy publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-006-1036-7 – volume: 137 start-page: 72 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0065 article-title: Temporal and spatial variation in pharmaceutical concentrations in an urban river system publication-title: Water Res. doi: 10.1016/j.watres.2018.02.066 – volume: 19 start-page: 585 year: 2012 ident: 10.1016/j.envint.2019.04.034_bb0285 article-title: Triclosan—the forgotten priority substance? publication-title: Environ. Sci. Pollut. Res. doi: 10.1007/s11356-011-0580-7 – volume: 21 start-page: 2031 year: 2012 ident: 10.1016/j.envint.2019.04.034_bb0120 article-title: Risk assessment of chlortetracycline, oxytetracycline, sulfamethazine, sulfathiazole, and erythromycin in aquatic environment: are the current environmental concentrations safe? publication-title: Ecotoxicology doi: 10.1007/s10646-012-0956-6 – volume: 36 start-page: 1202 year: 2002 ident: 10.1016/j.envint.2019.04.034_bb0145 article-title: Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999−2000: a national reconnaissance publication-title: Environ. Sci. Technol. doi: 10.1021/es011055j – volume: 140 start-page: 291 year: 2018 ident: 10.1016/j.envint.2019.04.034_bb0305 article-title: Typical pharmaceuticals in major WWTPs in Beijing, China: occurrence, load pattern and calculation reliability publication-title: Water Res. doi: 10.1016/j.watres.2018.04.056 – volume: 59 start-page: 208 year: 2013 ident: 10.1016/j.envint.2019.04.034_bb0165 article-title: Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China publication-title: Environ. Int. doi: 10.1016/j.envint.2013.06.012 – volume: 46 start-page: 272 year: 2011 ident: 10.1016/j.envint.2019.04.034_bb0300 article-title: Spatial and seasonal distribution of selected antibiotics in surface waters of the Pearl Rivers, China publication-title: J. Environ. Sci. Health B doi: 10.1080/03601234.2011.540540 – volume: 17 start-page: 526 year: 2008 ident: 10.1016/j.envint.2019.04.034_bb0215 article-title: Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystems publication-title: Ecotoxicology doi: 10.1007/s10646-008-0209-x – volume: 603 start-page: 487 year: 2017 ident: 10.1016/j.envint.2019.04.034_bb0255 article-title: Risk assessment of triclosan released from sewage treatment plants in European rivers using a combination of risk quotient methodology and Monte Carlo simulation publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2017.06.113 |
| SSID | ssj0002485 |
| Score | 2.6588264 |
| Snippet | Pharmaceuticals in surface waters have raised significant concern in recent years for their potential environmental effects. This study identified that at... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1 |
| SubjectTerms | aquatic ecosystems aquatic environment drugs Emerging pollutants environmental impact Europe metabolites Pharmaceuticals pollutants Prioritization risk Risk assessment surface water therapeutics |
| SummonAdditionalLinks | – databaseName: Elsevier SD Freedom Collection dbid: .~1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELWqnkAIwUJh-ZKRuIZNHNtJjqVqVXGAA1TqzbIdG4JKEm121VvV_9BLfx-_pDOOs-0eoBLHzY6zyXo885zMvEfIh6LUVjKP-i6w0-GS6cRwVySQ_GyVlpwVdai2-CKPT_jnU3G6Qw6mXhgsq4yxf4zpIVrHI4v4by76pll8Q240nkECK5FUrkDGT84L9PKPF7dlHkjZNfJ7pwlaT-1zocYLm8larKjMqkB4mvOt9BRY_Ley1N9QaMhGR0_I4wgj6f54pU_Jjmtn5OEdcsEZ2Tu87WED07iIhxl5ND6qo2MH0jNy_RXCxu_Yj0k7TyGSwO4WTpKcYUkRxfJzqjcUnlS3Ne2XTYe6d3QIQjpxJHYbo-oR7VFBGQWKB_rn8oqCM1IL-RJt-p93n6IPtGnp9EqADuulh6_ouUbSz-fk5Ojw-8FxEgUbEiuKfJWUljNjK2lFxUwtfG25TzNTOsON9kwKgJe5NrrGBqM8dbl1mRcaUJI0pWcu3yO7bde6l4RmXAujra8y4WGw1E5IDWiprgGvOFnNST7Nk7KRzRxFNc7UVLb2S42zq3B2VcoVzO6cJJtR_cjmcY_9J3SBjS1ycYcD3fKHis6orLfclKLOXKF5Bts3Y1htNfMsqIL5OSkmB1Jbrg2nau75-feTvylY9fgqR7euWw-KsUwCcAd__pcNyhtzgNhz8mJ01s2NAKgHHFLkr_772l6TB_hprFx-Q3ZXy7V7C_hsZd6FBXgDCCE9xg priority: 102 providerName: Elsevier |
| Title | Optimization of screening-level risk assessment and priority selection of emerging pollutants – The case of pharmaceuticals in European surface waters |
| URI | https://dx.doi.org/10.1016/j.envint.2019.04.034 https://www.ncbi.nlm.nih.gov/pubmed/31029973 https://www.proquest.com/docview/2216774120 https://www.proquest.com/docview/2237544835 https://doaj.org/article/cfc4b85d1e7a41768bb2dca2f273168f |
| Volume | 128 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nj9MwEB3BcgEhBIWF8lEZiWsgdmwnOS5oVwWk5cJKe7NsxxaLlrRqWnFD_Acu_D5-CTNxUroH6IVrMs6Xx55nZ-Y9gBdlZb0WkfRdcKUjtbCZk6HMMPj5Oq-kKJs-2-JUz8_ku3N1viP1RTlhiR44fbhXPnrpKtXwUFrJERw7JxpvRRS95lKk2Rdj3riYGuZgIupKrN55JrnIx6K5PrOLSshayqPkdU9zWsgrQann7r8Sm_6GPfsYdHIX7gzgkR2lh74H10I7gVs7lIITODz-U7mGpsPQ7SZwO23QsVR3dB9-fsDJ4stQhckWkeH8gWtavEh2SYlEjJLOmd0SdzLbNmy5uliQ2h3revmcoSXVGJPWEVuSbjLJEnfs1_cfDF2QeYySZLP8tLt33rGLlo0_Ali3WUU8xb5aovp8AGcnxx_fzLNBpiHzqizWWeWlcL7WXtXCNSo2Xsacuyo46WwUWiGoLKyzDZUVFXkofOBRWcRG2lVRhOIQDtpFGx4B49IqZ32suYrYWNugtEWM1DSIUoKup1CM_WT8wGFOUhqXZkxW-2xS7xrqXZNLg707hWzbapk4PPbYvyYX2NoSA3d_AP3SDH5p9vnlFMrRgcwAZhJIwUtd7Ln989HfDI51-oFj27DYdEYIrhGuoz__y4ZEjSUC6yk8TM66fRGE8og-yuLx_3jBJ3CTHjqlLj-Fg_VqE54hQFu7GVx_-Y3P4MbR2_fz01k_Mn8D4mU_7g |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VcgCEECwUlqeR4Bg2cZzXgQOPVltayoFW6s3Yjg1BJYk2u6q4IP4DF_4H_4hfwkwe2-4BKiH1mtjOY8bzSGa-D-BJkioTc0f8LpjpiJgrTwubeOj8TOangid5W22xF08PxJvD6HANfg29MFRW2dv-zqa31ro_Munf5qQuisl7wkYTATqwlEDlkoHBesd-Pca8rXm-_RqF_JTzrc39V1OvpxbwTJSEcy81gmuTxSbKuM4jlxvh_ECnVgutHI8jDIRCpVVOrTChb0NjAxcp9OexTh23Ia57AS4KNBdEm_Ds20ldCWGEdYDivke3N_TrtUVl1L1WUglnkLUIq6FY8YctbcCKW_xb2Nu6v63rcK2PW9mL7tXcgDVbjuDKKTTDEWxsnjTN4dDeajQjuNp9G2Rdy9NN-PkO7dSXvgGUVY6h6cJ0GhfxjqiGiVG9O1NLzFCmypzVs6Iioj3WtMw9_UxqbyaaJVYTZTMxIjfs9_cfDLWfGXTQNKb-dPqzfcOKkg3_IFizmDk8xY4VoYzegoNzEeMGrJdVae8AC4SKtDIuCyKHk2Nlo1hheJbnGCDZOBtDOMhJmh4-nVg8juRQJ_dZdtKVJF3pC4nSHYO3nFV38CFnjH9JKrAcS-Df7YFq9lH22i-NM0KnUR7YRIkA80WteW4Ud7ylIXNjSAYFkit7CZcqzrj840HfJJoZ-nekSlstGsl5EGOmgPr8rzHEpywwph_D7U5Zlw-CWQQGPkl497_v7RFcmu6_3ZW723s79-AynenKpu_D-ny2sA8wOJzrh-1mZPDhvHf_HyMHfOA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Optimization+of+screening-level+risk+assessment+and+priority+selection+of+emerging+pollutants+-+The+case+of+pharmaceuticals+in+European+surface+waters&rft.jtitle=Environment+international&rft.au=Zhou%2C+Shangbo&rft.au=Di+Paolo%2C+Carolina&rft.au=Wu%2C+Xinda&rft.au=Shao%2C+Ying&rft.date=2019-07-01&rft.eissn=1873-6750&rft.volume=128&rft.spage=1&rft_id=info:doi/10.1016%2Fj.envint.2019.04.034&rft_id=info%3Apmid%2F31029973&rft.externalDocID=31029973 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0160-4120&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0160-4120&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0160-4120&client=summon |