Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro

• Published in: Breast cancer research and treatment Vol. 155; no. 2; pp. 261 - 271
• Main Authors: Tuomela, Johanna M., Sandholm, Jouko A., Kaakinen, Mika, Hayden, Katherine L., Haapasaari, Kirsi-Maria, Jukkola-Vuorinen, Arja, Kauppila, Joonas H., Lehenkari, Petri P., Harris, Kevin W., Graves, David E., Selander, Katri S.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2016; Springer; Springer Nature B.V
• Subjects: Antimicrobial Cationic Peptides - genetics; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer cells; Cancer genetics; Cancer research; Cancer therapies; Cell adhesion & migration; Cell Line, Tumor; Chemotherapy; Deoxyribonucleic acid; DNA; DNA Fragmentation; DNA, Neoplasm - genetics; Female; G-Quadruplexes; Genetic research; Humans; Ligands; Medicine; Medicine & Public Health; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; Oncology; Preclinical Study; Proteases; Protein expression; RNA; RNA, Messenger - genetics; Telomere - genetics; Toll-Like Receptor 9 - genetics; 9-mer hairpin DNA; LL-37; Toll-like receptor 9; Invasion; Telomeric G-quadruplex DNA

Toll-like receptor 9 (TLR9) is a cellular DNA-receptor widely expressed in cancers. We previously showed that synthetic and self-derived DNA fragments induce TLR9-mediated breast cancer cell invasion in vitro. We investigated here the invasive effects of two nuclease-resistant DNA fragments, a 9-mer...