Identification of potential gene signatures associated with osteosarcoma by integrated bioinformatics analysis

• Published in: PeerJ (San Francisco, CA) Vol. 9; p. e11496
• Main Authors: Jia, Yutao, Liu, Yang, Han, Zhihua, Tian, Rong
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 27.05.2021; PeerJ, Inc; PeerJ Inc
• Subjects: Activating transcription factor; Binding sites; Bioinformatic; Bioinformatics; Biomarkers; Bone cancer; Bones; CXCL12 protein; Cytochrome P-450; Datasets; Diagnosis; DNA microarrays; Gene expression; Genes; Genetic aspects; Genetic transcription; Genomes; Health aspects; Integration; Medical diagnosis; Medical Genetics; Metastasis; Mortality; Oncology; Orthopedics; Osteosarcoma; Pathogenesis; Protein-protein interactions; Proteins; Rheumatology; Software; Taiwan; Taiwan; Bioinformatic; Activating transcription factor; Diagnosis; Osteosarcoma; Genes

Osteosarcoma (OS) is the most primary malignant bone cancer in children and adolescents with a high mortality rate. This work aims to screen novel potential gene signatures associated with OS by integrated microarray analysis of the Gene Expression Omnibus (GEO) database. The OS microarray datasets...