Metagenomic Next-Generation Sequencing for Diagnostically Challenging Mucormycosis in Patients with Hematological Malignancies

• Published in: Infection and drug resistance Vol. 15; pp. 7509 - 7517
• Main Authors: Zhang, Meng, Lu, Wenyi, Xie, Danni, Wang, Jiaxi, Xiao, Xia, Pu, Yedi, Meng, Juanxia, Lyu, Hairong, Zhao, Mingfeng
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2022; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Bacteria; Biopsy; Cancer; Cancer patients; Cancer therapies; Care and treatment; Cell culture; Corticosteroids; Debridement; Diagnosis; Disease; Fungal infections; Fungi; Genomes; Glucocorticoids; Health aspects; hematological malignancies; Hematology; Hematopoietic stem cells; Histopathology; Immunosuppression; Immunotherapy; Inflammation; invasive fungal disease; Laboratories; Malignancy; Medical diagnosis; metagenomic next-generation sequencing; Metagenomics; Mortality; Mucormycosis; Neutropenia; Next-generation sequencing; Patients; Pleural effusion; Reading; retrospectively; Risk factors; Short Report; Sinuses; Stem cell transplantation; Thrombocytopenia; Transplantation; Viruses; China; hematological malignancies; invasive fungal disease; retrospectively; metagenomic next-generation sequencing; mucormycosis

Metagenomic next-generation sequencing (mNGS) is a fast, sensitive and accurate diagnostic method for pathogens detection. However, reports on the application of mNGS in mucormycosis remain scarce. From January 2019 to December 2021, we recruited 13 patients with hematological malignancies who were...