Optimal experimental designs for dose–response studies with continuous endpoints

In most areas of clinical and preclinical research, the required sample size determines the costs and effort for any project, and thus, optimizing sample size is of primary importance. An experimental design of dose–response studies is determined by the number and choice of dose levels as well as th...

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Bibliographic Details
Published inArchives of toxicology Vol. 89; no. 11; pp. 2059 - 2068
Main Authors Holland-Letz, Tim, Kopp-Schneider, Annette
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2015
Springer Nature B.V
Subjects
Animals
Bayes Theorem
Biomedical and Life Sciences
Biomedicine
Design of experiments
Dose-Response Relationship, Drug
Endpoint Determination
Environmental Health
Humans
Models, Theoretical
Occupational Medicine/Industrial Medicine
Organ Toxicity and Mechanisms
Pharmacology/Toxicology
Research Design
Sample Size
Toxicity Tests - methods
Toxicology
Toxicology - methods
D-optimal design
Log-normal function
Weibull function
Log-logistic function
Dose response modelling
3T3/NHK guideline
Online AccessGet full text
ISSN0340-5761
1432-0738
1432-0738
DOI10.1007/s00204-014-1335-2

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