Imatinib increases apoptosis index through modulation of survivin subcellular localization in the blast phase of CML cells
Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell line, the hi...
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| Published in | Leukemia research Vol. 36; no. 12; pp. 1510 - 1516 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.12.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0145-2126 1873-5835 1873-5835 |
| DOI | 10.1016/j.leukres.2012.08.014 |
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| Abstract | Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell line, the high apoptosis index induced by imatinib was associated with the survivin predominantly in the nucleus. In the Lucena cell line, the low apoptosis index induced by imatinib was associated with a cytoplasmatic survivin localization. Pgp and survivin might be subject to the same molecular regulation, and therefore represent a therapeutic target in the blast phase of CML. |
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| AbstractList | Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell line, the high apoptosis index induced by imatinib was associated with the survivin predominantly in the nucleus. In the Lucena cell line, the low apoptosis index induced by imatinib was associated with a cytoplasmatic survivin localization. Pgp and survivin might be subject to the same molecular regulation, and therefore represent a therapeutic target in the blast phase of CML. Abstract Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell line, the high apoptosis index induced by imatinib was associated with the survivin predominantly in the nucleus. In the Lucena cell line, the low apoptosis index induced by imatinib was associated with a cytoplasmatic survivin localization. Pgp and survivin might be subject to the same molecular regulation, and therefore represent a therapeutic target in the blast phase of CML. Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell line, the high apoptosis index induced by imatinib was associated with the survivin predominantly in the nucleus. In the Lucena cell line, the low apoptosis index induced by imatinib was associated with a cytoplasmatic survivin localization. Pgp and survivin might be subject to the same molecular regulation, and therefore represent a therapeutic target in the blast phase of CML.Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two blast phase of chronic myeloid leukemia (CML) cell lines: K562 P-glycoprotein (Pgp)-negative, and Lucena, Pgp-positive. In K562 cell line, the high apoptosis index induced by imatinib was associated with the survivin predominantly in the nucleus. In the Lucena cell line, the low apoptosis index induced by imatinib was associated with a cytoplasmatic survivin localization. Pgp and survivin might be subject to the same molecular regulation, and therefore represent a therapeutic target in the blast phase of CML. |
| Author | Bernardo, Paula Sabbo Maia, Raquel Ciuvalschi Reis, Flaviana Ruade de Souza |
| Author_xml | – sequence: 1 givenname: Paula Sabbo surname: Bernardo fullname: Bernardo, Paula Sabbo organization: Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Pesquisa em Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Rio de Janeiro (RJ), Brazil – sequence: 2 givenname: Flaviana Ruade de Souza surname: Reis fullname: Reis, Flaviana Ruade de Souza organization: Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Pesquisa em Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Rio de Janeiro (RJ), Brazil – sequence: 3 givenname: Raquel Ciuvalschi surname: Maia fullname: Maia, Raquel Ciuvalschi email: rcmaia@inca.gov.br organization: Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Pesquisa em Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Rio de Janeiro (RJ), Brazil |
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| CitedBy_id | crossref_primary_10_1002_stem_2727 crossref_primary_10_1161_CIRCRESAHA_116_305265 crossref_primary_10_1016_j_blre_2020_100671 crossref_primary_10_1371_journal_pone_0156260 crossref_primary_10_3390_molecules23010119 crossref_primary_10_3748_wjg_v20_i48_18346 crossref_primary_10_1042_BSR20130067 |
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| Keywords | P-glycoprotein Imatinib Chronic myeloid leukemia Survivin Subcellular localization |
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| Snippet | Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in two... Abstract Using MTT, Annexin V/flow cytometry, immunocytochemistry, subcellular fractionation, and Western blotting assays we analyzed the effect of imatinib in... |
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| SubjectTerms | Annexin A5 - metabolism Annexin V Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Benzamides Blast Blast Crisis - drug therapy Blast Crisis - genetics Blast Crisis - pathology Blotting, Western Cell Nucleus - metabolism Cell Nucleus - pathology Cell Survival - drug effects Chronic myeloid leukemia Cytoplasm - metabolism Cytoplasm - pathology Flow Cytometry Gene Expression Regulation, Neoplastic Hematology, Oncology and Palliative Medicine Humans Imatinib Imatinib Mesylate Immunocytochemistry Immunohistochemistry Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Nuclei P-Glycoprotein Piperazines - pharmacology Pyrimidines - pharmacology Subcellular localization Survivin Tumor cell lines Western blotting |
| Title | Imatinib increases apoptosis index through modulation of survivin subcellular localization in the blast phase of CML cells |
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