SATB1 promotion of trophoblast stem cell renewal through regulation of threonine dehydrogenase

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 1; p. 129757
• Main Authors: Kubota, Kaiyu, Iqbal, Khursheed, Soares, Michael J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2021
• Subjects: Alcohol Oxidoreductases - metabolism; Animals; Cell Line; Cell Self Renewal; Homeodomain Proteins - metabolism; Placenta; Rats; Rats, Sprague-Dawley; SATB1; Stem Cells - cytology; Stem Cells - metabolism; Threonine dehydrogenase; Trophoblast stem cells; Trophoblasts - cytology; Trophoblasts - metabolism; Placenta; SATB1; Trophoblast stem cells; Threonine dehydrogenase

Trophoblast stem (TS) cell renewal and differentiation are essential processes in placentation. Special AT-rich binding protein 1 (SATB1) is a key regulator of the TS cell stem state. In this study, we identified SATB1 downstream targets and investigated their actions. RNA-sequencing analysis was pe...