The exposure-response relationship between temperature and childhood hand, foot and mouth disease: A multicity study from mainland China

• Published in: Environment international Vol. 100; pp. 102 - 109
• Main Authors: Xiao, Xiong, Gasparrini, Antonio, Huang, Jiao, Liao, Qiaohong, Liu, Fengfeng, Yin, Fei, Yu, Hongjie, Li, Xiaosong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2017; Elsevier
• Subjects: altitude; Child; Child, Preschool; childhood; Childhood infectious disease; China; China - epidemiology; cities; climatic factors; Enterovirus - pathogenicity; hand, foot and mouth disease; Hand, Foot and Mouth Disease - epidemiology; Hand, Foot and Mouth Disease - virology; Humans; Incidence; Infant; Infant, Newborn; Modification effect; Multisite study; Nonlinear association; Nonlinear Dynamics; nonlinear models; Public Health; rain; relative risk; Temperature; Temperature-disease relationship; Urban Population; China; Childhood infectious disease; Nonlinear association; TSR; Temperature-disease relationship; HFMD; LR; AIC; Multisite study; DOW; Modification effect

Hand, foot and mouth disease (HFMD) is a rising public health issue in the Asia-Pacific region. Numerous studies have tried to quantify the relationship between meteorological variables and HFMD but with inconsistent results, in particular for temperature. We aimed to characterize the relationship b...