T cell mediated immunity against influenza H5N1 nucleoprotein, matrix and hemagglutinin derived epitopes in H5N1 survivors and non-H5N1 subjects

• Published in: PeerJ (San Francisco, CA) Vol. 9; p. e11021
• Main Authors: Noisumdaeng, Pirom, Roytrakul, Thaneeya, Prasertsopon, Jarunee, Pooruk, Phisanu, Lerdsamran, Hatairat, Assanasen, Susan, Kitphati, Rungrueng, Auewarakul, Prasert, Puthavathana, Pilaipan
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 10.03.2021; PeerJ, Inc; PeerJ Inc
• Subjects: Antigenic determinants; Avian flu; Avian influenza; Avian influenza H5N1 virus; Blood banks; Cell culture; Cell-mediated immunity; Effector cells; Enzyme-linked immunosorbent assay; Epitopes; Flow cytometry; H5N1 survivors; Health aspects; Hemagglutinin; Hemagglutinins; Immune response; Immune response (cell-mediated); Immunology; Immunoreactivity; Infections; Infectious Diseases; Influenza A; Influenza vaccines; Influenza viruses; Lectins; Lymphocytes; Lymphocytes T; Matrix protein; Microbiology; Nucleoprotein; Peptides; Proteins; Swine flu; T cells; Tumor necrosis factor-α; Vaccines; Viral infections; Virology; Virus diseases; Viruses; γ-Interferon; Thailand; Flow cytometry; Avian influenza H5N1 virus; H5N1 survivors; Cell-mediated immunity; Immunodominant epitope; Hemagglutinin; Nucleoprotein; Matrix protein; T lymphocyte; ELISpot assay

Protection against the influenza virus by a specific antibody is relatively strain specific; meanwhile broader immunity may be conferred by cell-mediated immune response to the conserved epitopes across influenza virus subtypes. A universal broad-spectrum influenza vaccine which confronts not only s...