Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair - Sulkowski, Parker L.; Sundaram, Ranjini K.; Oeck, Sebastian; Corso, Christopher D.; Liu, Yanfeng; Noorbakhsh, Seth; Niger, Monica; Boeke, Marta; Ueno, Daiki; Kalathil, Aravind Nambiar; Bao, Xun; Li, Jing; et al. (Nature genetics, 2018)
Keywords: 13; 13/106; 13/44; 13/89; 14; 14/1; 14/63; 631/208; 631/67; 631/67/589; 64/60; 82/29; Adenosine diphosphate; Adrenal Gland Neoplasms - genetics; Agriculture; Animal Genetics and Genomics; Biomedical and Life Sciences; Biomedicine; Biotechnology; Cancer; Cancer cells; Cancer genetics; Cancer metastasis; Cancer Research; Cell Line; Cell Line, Tumor; Citric Acid Cycle - drug effects; Citric Acid Cycle - genetics; Dehydrogenases; Deoxyribonucleic acid; Disorders; DNA; DNA Breaks, Double-Stranded; DNA damage; DNA repair; Enzymes; Epigenetics; Fibroids; Fumarase; Fumarates - pharmacology; Gene Function; Genes; Germ-Line Mutation; HEK293 Cells; Homologous recombination; Homology; Human Genetics; Humans; Ionizing radiation; Kidney cancer; Krebs cycle; Leiomyomatosis - genetics; Letter; Medical schools; Metabolites; Metastases; Monosaccharides; Mutation; Neoplastic Syndromes, Hereditary - genetics; Paraganglioma; Pheochromocytoma; Pheochromocytoma - genetics; Poly(ADP-ribose) polymerase; Recombinational DNA Repair; Renal cell carcinoma; Repair; Ribose; Skin Neoplasms - genetics; Succinate dehydrogenase; Succinic Acid - pharmacology; Tricarboxylic acid cycle; Tumor cells; Tumors; Uterine Neoplasms - genetics