Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease

• Published in: Clinical interventions in aging Vol. 15; pp. 1809 - 1820
• Main Authors: He, Wei, Luo, Yao, Liu, Jun-Peng, Sun, Ning, Guo, Di, Cui, Ling-Ling, Zheng, Pei-Pei, Yao, Si-Min, Yang, Jie-Fu, Wang, Hua
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Age; Aged; Aged, 80 and over; Aging; Alzheimer's disease; Biomarkers; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cognition Disorders - epidemiology; Cognitive ability; cognitive frailty; Cross-Sectional Studies; Diabetes; Ejection fraction; Female; Frail elderly; Frail Elderly - statistics & numerical data; Frailty; Gastrointestinal Microbiome - physiology; Geriatric Assessment; Geriatrics; Gut microbiota; Health aspects; Humans; Laboratories; Male; Metabolites; Methylamines - blood; Microbiota; Microbiota (Symbiotic organisms); Middle Aged; older adults; Older people; Original Research; physical frailty; Regression analysis; Risk Factors; Statistical analysis; tmao; China; Beijing China; TMAO; older adults; cardiovascular disease; frailty; physical frailty; cognitive frailty

Our study aimed to explore the association between trimethylamine N-oxide and frailty in older adults with cardiovascular disease. This cross-sectional study analyzed a total of 451 people aged 65 years or older who underwent comprehensive geriatric assessments. Frailty status was determined using a...