Topical Application of γ-Tocopherol Derivative Prevents UV-Induced Skin Pigmentation

• Published in: Biological & pharmaceutical bulletin Vol. 29; no. 6; pp. 1175 - 1179
• Main Authors: Kuwabara, Yuka, Watanabe, Tatsuya, Yasuoka, Shingo, Fukui, Kohsuke, Takata, Jiro, Karube, Yoshiharu, Okamoto, Yuko, Asano, Shin, Katoh, Eiko, Tsuzuki, Toshi, Kobayashi, Shizuko
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.06.2006
• Subjects: Administration, Topical; Animals; Cell Line, Tumor; gamma-Tocopherol - administration & dosage; gamma-Tocopherol - analogs & derivatives; gamma-Tocopherol - therapeutic use; Glycine - administration & dosage; Glycine - analogs & derivatives; Glycine - therapeutic use; Guinea Pigs; hyper-pigmentation; Melanins - biosynthesis; melanogenesis; Skin - drug effects; Skin - metabolism; Skin - radiation effects; Skin Pigmentation - drug effects; Skin Pigmentation - radiation effects; tyrosinase; ultraviolet light B; Ultraviolet Rays; γ-tocopherol; γ-tocopheryl-N,N-dimethylglycinate hydrochloride

We previously reported that a novel hydrophilic γ-tocopherol (γ-Toc) derivative, γ-tocopheryl-N,N-dimethylglycinate hydrochloride (γ-TDMG) gets converted to the antioxidant γ-Toc in skin. We also found that this derivative displayed greater bioavailability than γ-Toc itself. In the present study, we...