Increased Stress-Induced Dopamine Release in Psychosis
A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in...
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| Published in | Biological psychiatry (1969) Vol. 71; no. 6; pp. 561 - 567 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
15.03.2012
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0006-3223 1873-2402 1873-2402 |
| DOI | 10.1016/j.biopsych.2011.10.009 |
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| Abstract | A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis.
Using the ability of endogenous dopamine (DA) to compete with [11C]-(+)-PHNO binding, as measured with positron emission tomography, we examined stress-induced DA release in response to a validated psychosocial stress task. We studied 12 clinical high-risk (CHR), 10 antipsychotic-naive subjects with schizophrenia (SCZ), and 12 matched healthy volunteers (HV). Stress-induced DA release was estimated as the percent change in binding potential between conditions (stress and control scan) in the striatal subdivisions: limbic striatum (LST), associative striatum (AST), and sensorimotor striatum (SMST).
We found a significant difference between groups in the AST (F = 8.13, df = 2,31, p = .001), and at the SMST (F = 3,64, df = 2,31, p = .03) but not in the LST (F = .43, df = 2,31, p = .40) with CHR and SCZ having larger [11C]-(+)-PHNO displacement in response to the stress. Bonferroni-corrected comparisons confirmed that HV displacement (–2.86%) in the AST was significantly different in CHR (6.97%) and SCZ (11.44%) (with no significant difference between CHR and SCZ).
This study reveals a sensitized dopaminergic response to stress in a psychiatric condition and may have important theoretical and clinical implications regarding efforts to abort or delay relapse and/or conversion to psychosis. |
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| AbstractList | A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis.
Using the ability of endogenous dopamine (DA) to compete with [(11)C]-(+)-PHNO binding, as measured with positron emission tomography, we examined stress-induced DA release in response to a validated psychosocial stress task. We studied 12 clinical high-risk (CHR), 10 antipsychotic-naive subjects with schizophrenia (SCZ), and 12 matched healthy volunteers (HV). Stress-induced DA release was estimated as the percent change in binding potential between conditions (stress and control scan) in the striatal subdivisions: limbic striatum (LST), associative striatum (AST), and sensorimotor striatum (SMST).
We found a significant difference between groups in the AST (F = 8.13, df = 2,31, p = .001), and at the SMST (F = 3,64, df = 2,31, p = .03) but not in the LST (F = .43, df = 2,31, p = .40) with CHR and SCZ having larger [(11)C]-(+)-PHNO displacement in response to the stress. Bonferroni-corrected comparisons confirmed that HV displacement (-2.86%) in the AST was significantly different in CHR (6.97%) and SCZ (11.44%) (with no significant difference between CHR and SCZ).
This study reveals a sensitized dopaminergic response to stress in a psychiatric condition and may have important theoretical and clinical implications regarding efforts to abort or delay relapse and/or conversion to psychosis. A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis.BACKGROUNDA pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis.Using the ability of endogenous dopamine (DA) to compete with [(11)C]-(+)-PHNO binding, as measured with positron emission tomography, we examined stress-induced DA release in response to a validated psychosocial stress task. We studied 12 clinical high-risk (CHR), 10 antipsychotic-naive subjects with schizophrenia (SCZ), and 12 matched healthy volunteers (HV). Stress-induced DA release was estimated as the percent change in binding potential between conditions (stress and control scan) in the striatal subdivisions: limbic striatum (LST), associative striatum (AST), and sensorimotor striatum (SMST).METHODSUsing the ability of endogenous dopamine (DA) to compete with [(11)C]-(+)-PHNO binding, as measured with positron emission tomography, we examined stress-induced DA release in response to a validated psychosocial stress task. We studied 12 clinical high-risk (CHR), 10 antipsychotic-naive subjects with schizophrenia (SCZ), and 12 matched healthy volunteers (HV). Stress-induced DA release was estimated as the percent change in binding potential between conditions (stress and control scan) in the striatal subdivisions: limbic striatum (LST), associative striatum (AST), and sensorimotor striatum (SMST).We found a significant difference between groups in the AST (F = 8.13, df = 2,31, p = .001), and at the SMST (F = 3,64, df = 2,31, p = .03) but not in the LST (F = .43, df = 2,31, p = .40) with CHR and SCZ having larger [(11)C]-(+)-PHNO displacement in response to the stress. Bonferroni-corrected comparisons confirmed that HV displacement (-2.86%) in the AST was significantly different in CHR (6.97%) and SCZ (11.44%) (with no significant difference between CHR and SCZ).RESULTSWe found a significant difference between groups in the AST (F = 8.13, df = 2,31, p = .001), and at the SMST (F = 3,64, df = 2,31, p = .03) but not in the LST (F = .43, df = 2,31, p = .40) with CHR and SCZ having larger [(11)C]-(+)-PHNO displacement in response to the stress. Bonferroni-corrected comparisons confirmed that HV displacement (-2.86%) in the AST was significantly different in CHR (6.97%) and SCZ (11.44%) (with no significant difference between CHR and SCZ).This study reveals a sensitized dopaminergic response to stress in a psychiatric condition and may have important theoretical and clinical implications regarding efforts to abort or delay relapse and/or conversion to psychosis.CONCLUSIONSThis study reveals a sensitized dopaminergic response to stress in a psychiatric condition and may have important theoretical and clinical implications regarding efforts to abort or delay relapse and/or conversion to psychosis. A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis. Using the ability of endogenous dopamine (DA) to compete with [11C]-(+)-PHNO binding, as measured with positron emission tomography, we examined stress-induced DA release in response to a validated psychosocial stress task. We studied 12 clinical high-risk (CHR), 10 antipsychotic-naive subjects with schizophrenia (SCZ), and 12 matched healthy volunteers (HV). Stress-induced DA release was estimated as the percent change in binding potential between conditions (stress and control scan) in the striatal subdivisions: limbic striatum (LST), associative striatum (AST), and sensorimotor striatum (SMST). We found a significant difference between groups in the AST (F = 8.13, df = 2,31, p = .001), and at the SMST (F = 3,64, df = 2,31, p = .03) but not in the LST (F = .43, df = 2,31, p = .40) with CHR and SCZ having larger [11C]-(+)-PHNO displacement in response to the stress. Bonferroni-corrected comparisons confirmed that HV displacement (–2.86%) in the AST was significantly different in CHR (6.97%) and SCZ (11.44%) (with no significant difference between CHR and SCZ). This study reveals a sensitized dopaminergic response to stress in a psychiatric condition and may have important theoretical and clinical implications regarding efforts to abort or delay relapse and/or conversion to psychosis. Background A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor in the triggering and relapse of psychosis. However, there is no direct evidence that brain dopaminergic response to stress is exaggerated in psychosis. Methods Using the ability of endogenous dopamine (DA) to compete with [11 C]-(+)-PHNO binding, as measured with positron emission tomography, we examined stress-induced DA release in response to a validated psychosocial stress task. We studied 12 clinical high-risk (CHR), 10 antipsychotic-naive subjects with schizophrenia (SCZ), and 12 matched healthy volunteers (HV). Stress-induced DA release was estimated as the percent change in binding potential between conditions (stress and control scan) in the striatal subdivisions: limbic striatum (LST), associative striatum (AST), and sensorimotor striatum (SMST). Results We found a significant difference between groups in the AST ( F = 8.13, df = 2,31, p = .001), and at the SMST ( F = 3,64, df = 2,31, p = .03) but not in the LST ( F = .43, df = 2,31, p = .40) with CHR and SCZ having larger [11 C]-(+)-PHNO displacement in response to the stress. Bonferroni-corrected comparisons confirmed that HV displacement (–2.86%) in the AST was significantly different in CHR (6.97%) and SCZ (11.44%) (with no significant difference between CHR and SCZ). Conclusions This study reveals a sensitized dopaminergic response to stress in a psychiatric condition and may have important theoretical and clinical implications regarding efforts to abort or delay relapse and/or conversion to psychosis. |
| Author | Boileau, Isabelle Mizrahi, Romina Pruessner, Jens C. Rusjan, Pablo M. Suridjan, Ivonne Ng, Alvina Addington, Jean Remington, Gary Houle, Sylvain Wilson, Alan A. |
| Author_xml | – sequence: 1 givenname: Romina surname: Mizrahi fullname: Mizrahi, Romina email: Romina.mizrahi@camhpet.ca organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada – sequence: 2 givenname: Jean surname: Addington fullname: Addington, Jean organization: Department of Psychiatry, University of Calgary, Alberta, Canada – sequence: 3 givenname: Pablo M. surname: Rusjan fullname: Rusjan, Pablo M. organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada – sequence: 4 givenname: Ivonne surname: Suridjan fullname: Suridjan, Ivonne organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada – sequence: 5 givenname: Alvina surname: Ng fullname: Ng, Alvina organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada – sequence: 6 givenname: Isabelle surname: Boileau fullname: Boileau, Isabelle organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada – sequence: 7 givenname: Jens C. surname: Pruessner fullname: Pruessner, Jens C. organization: McGill Centre for Studies in Aging, McGill University, Montreal, Canada – sequence: 8 givenname: Gary surname: Remington fullname: Remington, Gary organization: Department of Psychiatry, University of Toronto, Toronto, Canada – sequence: 9 givenname: Sylvain surname: Houle fullname: Houle, Sylvain organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada – sequence: 10 givenname: Alan A. surname: Wilson fullname: Wilson, Alan A. organization: Positron Emission Tomography Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada |
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| Cites_doi | 10.1097/00004647-200003000-00001 10.1001/archgenpsychiatry.2008.514 10.1016/j.neuroimage.2010.06.044 10.1093/oxfordjournals.schbul.a007040 10.1016/S0165-0173(99)00054-5 10.1093/oxfordjournals.schbul.a006896 10.1016/j.pscychresns.2006.01.011 10.1038/sj.npp.1301597 10.1176/appi.ajp.159.5.863 10.1016/S0893-133X(99)00153-0 10.1016/j.biopsych.2009.07.037 10.1002/syn.20282 10.1002/syn.20615 10.1017/S1461145710000088 10.1196/annals.1391.013 10.1016/j.biopsych.2010.04.038 10.1111/j.2044-8341.1979.tb02487.x 10.1016/j.neubiorev.2010.01.010 10.1016/j.pscychresns.2009.10.002 10.1136/bmj.323.7325.1336 10.1097/01.WCB.0000048520.34839.1A 10.1037/0021-843X.86.2.103 10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4 10.1016/j.biopsych.2005.02.012 10.1007/BF03033299 10.1016/0165-0173(91)90007-U 10.1016/S0006-3223(99)00067-0 10.1002/syn.20325 10.1017/S0954579401003169 10.1038/nature10190 10.1016/S0006-3223(00)01052-0 10.1002/syn.20013 10.1523/JNEUROSCI.3422-03.2004 10.1097/00006842-199903000-00012 10.1001/archgenpsychiatry.2007.3 10.1016/j.ijdevneu.2010.08.002 10.1038/nn798 10.1177/026988119901300405 10.1021/jm050155n 10.1038/mp.2011.20 10.1016/S0140-6736(07)61162-3 10.1176/appi.ajp.162.1.12 10.1016/0006-8993(93)90260-T 10.1001/archpsyc.1993.01820190043005 10.1016/0960-0760(92)90294-S 10.1038/sj.jcbfm.9600411 10.1111/j.1471-4159.2006.03840.x 10.1093/schbul/13.2.261 10.1016/S0306-4530(02)00108-7 10.1038/npp.1994.8 10.1016/j.biopsych.2007.04.041 10.1001/archgenpsychiatry.2010.10 10.1111/j.1471-4159.1989.tb09224.x |
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| Copyright | 2012 Society of Biological Psychiatry Society of Biological Psychiatry 2015 INIST-CNRS Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. |
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| Keywords | stress Dopamine schizophrenia positron emission tomography prodrome neuroimaging Radionuclide study Psychosis Neuroimaging Neurotransmitter Schizophrenia Prodrome Catecholamine Positron emission tomography Release Stress Emission tomography |
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| References | Narendran, Hwang, Slifstein, Talbot, Erritzoe, Huang (bib22) 2004; 52 Rabiner, Laruelle (bib59) 2010; 13 Walker, Walder, Reynolds (bib8) 2001; 13 Walder, Walker, Lewine (bib10) 2000; 48 Howes, Bose, Turkheimer, Valli, Egerton, Stahl (bib51) 2011; 16 Tziortzi, Searle, Tzimopoulou, Salinas, Beaver, Jenkinson (bib26) 2011; 54 Martinez, Orlowska, Narendran, Slifstein, Liu, Kumar (bib57) 2010; 67 Ginovart, Willeit, Rusjan, Graff, Bloomfield, Houle (bib43) 2007; 27 Lederbogen, Kirsch, Haddad, Streit, Tost, Schuch (bib35) 2011; 474 Laruelle (bib46) 1998; 42 Wilson, McCormick, Kapur, Willeit, Garcia, Hussey (bib21) 2005; 48 Booij, Welfeld, Dagher, Leyton, Boileau, Sibon (bib34) 2007 Laruelle, Abi-Dargham (bib5) 1999; 13 Dedovic, Renwick, Mahani, Engert, Lupien, Pruessner (bib32) 2005; 30 Pruessner, Dedovic, Khalili-Mahani, Engert, Pruessner, Buss (bib33) 2008; 63 Searle, Beaver, Comley, Bani, Tziortzi, Slifstein (bib25) 2010; 68 Miller, McGlashan, Rosen, Somjee, Markovich, Stein (bib29) 2002; 159 Pruessner, Hellhammer, Kirschbaum (bib36) 1999; 61 Boydell, van Os, McKenzie, Allardyce, Goel, McCreadie (bib53) 2001; 323 Hall, Wilkinson, Humby, Robbins (bib54) 1999; 32 Laruelle, Abi-Dargham, Gil, Kegeles, Innis (bib48) 1999; 46 Cannon, Cadenhead, Cornblatt, Woods, Addington, Walker (bib27) 2008; 65 Kay, Fiszbein, Opler (bib31) 1987; 13 Finnema, Halldin, Bang-Andersen, Gulyas, Bundgaard, Wikstrom (bib24) 2009; 63 Howes, Montgomery, Asselin, Murray, Valli, Tabraham (bib50) 2009; 66 Breier, Davis, Buchanan, Moricle, Munson (bib9) 1993; 50 Adler, Elman, Weisenfeld, Kestler, Pickar, Breier (bib17) 2000; 22 Lodge, Grace (bib11) 2011; 29 Myin-Germeys, Marcelis, Krabbendam, Delespaul, van Os (bib7) 2005; 58 Rousset, Ma, Evans (bib44) 1998; 39 Martinez, Slifstein, Broft, Mawlawi, Hwang, Huang (bib41) 2003; 23 Narendran, Slifstein, Guillin, Hwang, Hwang, Scher (bib61) 2006; 60 McGlashan, Miller, Woods (bib30) 2001; 27 Rusjan, Mamo, Ginovart, Hussey, Vitcu, Yasuno (bib42) 2006; 147 Wilkinson, Killcross, Humby, Hall, Geyer, Robbins (bib55) 1994; 10 Moore, Zammit, Lingford-Hughes, Barnes, Jones, Burke (bib2) 2007; 370 Pruessner, Kirschbaum, Meinlschmid, Hellhammer (bib40) 2003; 28 Miller, McGlashan, Rosen, Cadenhead, Cannon, Ventura (bib28) 2003; 29 Dressendorfer, Kirschbaum, Rohde, Stahl, Strasburger (bib39) 1992; 43 Foley, Kirschbaum (bib58) 2010; 35 Brunelin, d'Amato, Van Os, Costes, Suaud Chagny, Saoud (bib15) 2010; 181 Montgomery, Mehta, Grasby (bib19) 2006; 60 Kalivas, Stewart (bib49) 1991; 16 Ginovart, Galineau, Willeit, Mizrahi, Bloomfield, Seeman (bib23) 2006; 97 Kegeles, Abi-Dargham, Frankle, Gil, Cooper, Slifstein (bib52) 2010; 67 Laruelle (bib20) 2000; 20 Laruelle (bib47) 2000; 31 Abi-Dargham, Gil, Krystal, Baldwin, Seibyl, Bowers (bib45) 1998; 155 Shotbolt, Tziortzi, Searle, Colasanti, van der Aart, Abanades (bib60) 2011 Yui (bib6) 2007; 1113 Abercrombie, Keefe, DiFrischia, Zigmond (bib12) 1989; 52 Parker, Tupling, Brown (bib38) 1979; 52 Morgan, Grant, Gage, Mach, Kaplan, Prioleau (bib56) 2002; 5 Cantor-Graae, Selten (bib1) 2005; 162 Rouge-Pont, Piazza, Kharouby, Le Moal, Simon (bib13) 1993; 602 Moghaddam, Jackson (bib14) 2004; 6 Rabiner, Raymond, Diwan, McCormick, Wilson, Nobrega (bib3) 2007 Soliman, O'Driscoll, Pruessner, Holahan, Boileau, Gagnon (bib18) 2008; 33 Spielberger, Gorusch, Lushene, Vagg, Jacobs (bib37) 1977 Pruessner, Champagne, Meaney, Dagher (bib16) 2004; 24 Zubin, Spring (bib4) 1977; 86 Soliman (10.1016/j.biopsych.2011.10.009_bib18) 2008; 33 Ginovart (10.1016/j.biopsych.2011.10.009_bib43) 2007; 27 Breier (10.1016/j.biopsych.2011.10.009_bib9) 1993; 50 Moore (10.1016/j.biopsych.2011.10.009_bib2) 2007; 370 Howes (10.1016/j.biopsych.2011.10.009_bib51) 2011; 16 Miller (10.1016/j.biopsych.2011.10.009_bib29) 2002; 159 Brunelin (10.1016/j.biopsych.2011.10.009_bib15) 2010; 181 Parker (10.1016/j.biopsych.2011.10.009_bib38) 1979; 52 Abercrombie (10.1016/j.biopsych.2011.10.009_bib12) 1989; 52 Lodge (10.1016/j.biopsych.2011.10.009_bib11) 2011; 29 Walker (10.1016/j.biopsych.2011.10.009_bib8) 2001; 13 Ginovart (10.1016/j.biopsych.2011.10.009_bib23) 2006; 97 Walder (10.1016/j.biopsych.2011.10.009_bib10) 2000; 48 Shotbolt (10.1016/j.biopsych.2011.10.009_bib60) 2011 Kalivas (10.1016/j.biopsych.2011.10.009_bib49) 1991; 16 Booij (10.1016/j.biopsych.2011.10.009_bib34) 2007 Abi-Dargham (10.1016/j.biopsych.2011.10.009_bib45) 1998; 155 Pruessner (10.1016/j.biopsych.2011.10.009_bib33) 2008; 63 Montgomery (10.1016/j.biopsych.2011.10.009_bib19) 2006; 60 Rabiner (10.1016/j.biopsych.2011.10.009_bib3) 2007 Kegeles (10.1016/j.biopsych.2011.10.009_bib52) 2010; 67 Cannon (10.1016/j.biopsych.2011.10.009_bib27) 2008; 65 Narendran (10.1016/j.biopsych.2011.10.009_bib61) 2006; 60 Cantor-Graae (10.1016/j.biopsych.2011.10.009_bib1) 2005; 162 Kay (10.1016/j.biopsych.2011.10.009_bib31) 1987; 13 Pruessner (10.1016/j.biopsych.2011.10.009_bib40) 2003; 28 Hall (10.1016/j.biopsych.2011.10.009_bib54) 1999; 32 Laruelle (10.1016/j.biopsych.2011.10.009_bib20) 2000; 20 Spielberger (10.1016/j.biopsych.2011.10.009_bib37) 1977 Yui (10.1016/j.biopsych.2011.10.009_bib6) 2007; 1113 Laruelle (10.1016/j.biopsych.2011.10.009_bib5) 1999; 13 Wilkinson (10.1016/j.biopsych.2011.10.009_bib55) 1994; 10 Rousset (10.1016/j.biopsych.2011.10.009_bib44) 1998; 39 Adler (10.1016/j.biopsych.2011.10.009_bib17) 2000; 22 Lederbogen (10.1016/j.biopsych.2011.10.009_bib35) 2011; 474 Dedovic (10.1016/j.biopsych.2011.10.009_bib32) 2005; 30 Morgan (10.1016/j.biopsych.2011.10.009_bib56) 2002; 5 McGlashan (10.1016/j.biopsych.2011.10.009_bib30) 2001; 27 Moghaddam (10.1016/j.biopsych.2011.10.009_bib14) 2004; 6 Foley (10.1016/j.biopsych.2011.10.009_bib58) 2010; 35 Rabiner (10.1016/j.biopsych.2011.10.009_bib59) 2010; 13 Rouge-Pont (10.1016/j.biopsych.2011.10.009_bib13) 1993; 602 Martinez (10.1016/j.biopsych.2011.10.009_bib41) 2003; 23 Wilson (10.1016/j.biopsych.2011.10.009_bib21) 2005; 48 Rusjan (10.1016/j.biopsych.2011.10.009_bib42) 2006; 147 Finnema (10.1016/j.biopsych.2011.10.009_bib24) 2009; 63 Miller (10.1016/j.biopsych.2011.10.009_bib28) 2003; 29 Laruelle (10.1016/j.biopsych.2011.10.009_bib47) 2000; 31 Pruessner (10.1016/j.biopsych.2011.10.009_bib36) 1999; 61 Laruelle (10.1016/j.biopsych.2011.10.009_bib48) 1999; 46 Narendran (10.1016/j.biopsych.2011.10.009_bib22) 2004; 52 Laruelle (10.1016/j.biopsych.2011.10.009_bib46) 1998; 42 Howes (10.1016/j.biopsych.2011.10.009_bib50) 2009; 66 Tziortzi (10.1016/j.biopsych.2011.10.009_bib26) 2011; 54 Zubin (10.1016/j.biopsych.2011.10.009_bib4) 1977; 86 Pruessner (10.1016/j.biopsych.2011.10.009_bib16) 2004; 24 Searle (10.1016/j.biopsych.2011.10.009_bib25) 2010; 68 Boydell (10.1016/j.biopsych.2011.10.009_bib53) 2001; 323 Martinez (10.1016/j.biopsych.2011.10.009_bib57) 2010; 67 Myin-Germeys (10.1016/j.biopsych.2011.10.009_bib7) 2005; 58 Dressendorfer (10.1016/j.biopsych.2011.10.009_bib39) 1992; 43 |
| References_xml | – volume: 155 start-page: 761 year: 1998 end-page: 767 ident: bib45 article-title: Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort publication-title: Am J Psychiatry – volume: 63 start-page: 378 year: 2009 end-page: 389 ident: bib24 article-title: Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain—a comparative PET study with [11C]raclopride and [11C]MNPA publication-title: Synapse – year: 2011 ident: bib60 article-title: Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans [published online ahead of print August 31] publication-title: J Cereb Blood Flow Metab – volume: 20 start-page: 423 year: 2000 end-page: 451 ident: bib20 article-title: Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review publication-title: J Cereb Blood Flow Metab – volume: 60 start-page: 485 year: 2006 end-page: 495 ident: bib61 article-title: Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo publication-title: Synapse – volume: 29 start-page: 703 year: 2003 end-page: 715 ident: bib28 article-title: Prodromal assessment with the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive validity, inter-rater reliability, and training to reliability publication-title: Schizophr Bull – volume: 13 start-page: 261 year: 1987 end-page: 276 ident: bib31 article-title: The positive and negative syndrome scale (PANSS) for schizophrenia publication-title: Schizophr Bull – volume: 50 start-page: 541 year: 1993 end-page: 550 ident: bib9 article-title: Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia publication-title: Arch Gen Psychiatry – volume: 35 start-page: 91 year: 2010 end-page: 96 ident: bib58 article-title: Human hypothalamus-pituitary-adrenal axis responses to acute psychosocial stress in laboratory settings publication-title: Neurosci Biobehav Rev – volume: 60 start-page: 124 year: 2006 end-page: 131 ident: bib19 article-title: Is psychological stress in man associated with increased striatal dopamine levels? publication-title: Synapse – volume: 159 start-page: 863 year: 2002 end-page: 865 ident: bib29 article-title: Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: Preliminary evidence of interrater reliability and predictive validity publication-title: Am J Psychiatry – volume: 97 start-page: 1089 year: 2006 end-page: 1103 ident: bib23 article-title: Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography publication-title: J Neurochem – volume: 10 start-page: 61 year: 1994 end-page: 72 ident: bib55 article-title: Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition publication-title: Neuropsychopharmacology – volume: 48 start-page: 1121 year: 2000 end-page: 1132 ident: bib10 article-title: Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia publication-title: Biol Psychiatry – volume: 33 start-page: 2033 year: 2008 end-page: 2041 ident: bib18 article-title: Stress–induced dopamine release in humans at risk of psychosis: A [11C]raclopride PET study publication-title: Neuropsychopharmacology – volume: 30 start-page: 319 year: 2005 end-page: 325 ident: bib32 article-title: The Montreal Imaging Stress Task: Using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain publication-title: J Psychiatry Neurosci – volume: 602 start-page: 169 year: 1993 end-page: 174 ident: bib13 article-title: Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration publication-title: Brain Res – volume: 68 start-page: 392 year: 2010 end-page: 399 ident: bib25 article-title: Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist publication-title: Biol Psychiatry – volume: 66 start-page: 13 year: 2009 end-page: 20 ident: bib50 article-title: Elevated striatal dopamine function linked to prodromal signs of schizophrenia publication-title: Arch Gen Psychiatry – volume: 23 start-page: 285 year: 2003 end-page: 300 ident: bib41 article-title: Imaging human mesolimbic dopamine transmission with positron emission tomography publication-title: J Cereb Blood Flow Metab – volume: 67 start-page: 231 year: 2010 end-page: 239 ident: bib52 article-title: Increased synaptic dopamine function in associative regions of the striatum in schizophrenia publication-title: Arch Gen Psychiatry – year: 1977 ident: bib37 article-title: State and Trait Anxiety Inventory for Adults – volume: 13 start-page: 721 year: 2001 end-page: 732 ident: bib8 article-title: Developmental changes in cortisol secretion in normal and at-risk youth publication-title: Dev Psychopathol – volume: 65 start-page: 28 year: 2008 end-page: 37 ident: bib27 article-title: Prediction of psychosis in youth at high clinical risk: A multisite longitudinal study in North America publication-title: Arch Gen Psychiatry – volume: 52 start-page: 188 year: 2004 end-page: 208 ident: bib22 article-title: In vivo vulnerability to competition by endogenous dopamine: Comparison of the D2 receptor agonist radiotracer (–)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride publication-title: Synapse – volume: 13 start-page: 289 year: 2010 end-page: 290 ident: bib59 article-title: Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET) publication-title: Int J Neuropsychopharmacol – volume: 5 start-page: 169 year: 2002 end-page: 174 ident: bib56 article-title: Social dominance in monkeys: Dopamine D2 receptors and cocaine self-administration publication-title: Nat Neurosci – year: 2007 ident: bib3 article-title: D3 and D2 components of ex vivo regional (+)-PHNO brain binding in wild-type and knock-out mice publication-title: SNM 113P-b – volume: 29 start-page: 207 year: 2011 end-page: 213 ident: bib11 article-title: Developmental pathology, dopamine, stress and schizophrenia publication-title: Int J Dev Neurosci – volume: 42 start-page: 211 year: 1998 end-page: 221 ident: bib46 article-title: Imaging dopamine transmission in schizophrenia publication-title: Q J Nucl Med – year: 2007 ident: bib34 article-title: Cross-sensitization between stimulants and stress in humans: Behavioral and neurochemical correlates – volume: 54 start-page: 264 year: 2011 end-page: 277 ident: bib26 article-title: Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy publication-title: Neuroimage – volume: 27 start-page: 857 year: 2007 end-page: 871 ident: bib43 article-title: Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain publication-title: J Cereb Blood Flow Metab – volume: 31 start-page: 371 year: 2000 end-page: 384 ident: bib47 article-title: The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies publication-title: Brain Res Brain Res Rev – volume: 46 start-page: 56 year: 1999 end-page: 72 ident: bib48 article-title: Increased dopamine transmission in schizophrenia: relationship to illness phases publication-title: Biol Psychiatry – volume: 16 start-page: 885 year: 2011 end-page: 886 ident: bib51 article-title: Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: A PET study publication-title: Mol Psychiatry – volume: 67 start-page: 275 year: 2010 end-page: 278 ident: bib57 article-title: Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers publication-title: Biol Psychiatry – volume: 52 start-page: 1 year: 1979 end-page: 10 ident: bib38 article-title: A parental bonding instrument publication-title: Br J Med Psychology – volume: 24 start-page: 2825 year: 2004 end-page: 2831 ident: bib16 article-title: Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: A positron emission tomography study using [11C]raclopride publication-title: J Neurosci – volume: 43 start-page: 683 year: 1992 end-page: 692 ident: bib39 article-title: Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement publication-title: J Steroid Biochem Mol Biol – volume: 162 start-page: 12 year: 2005 end-page: 24 ident: bib1 article-title: Schizophrenia and migration: A meta-analysis and review publication-title: Am J Psychiatry – volume: 13 start-page: 358 year: 1999 end-page: 371 ident: bib5 article-title: Dopamine as the wind of the psychotic fire: New evidence from brain imaging studies publication-title: J Psychopharmacol – volume: 1113 start-page: 276 year: 2007 end-page: 290 ident: bib6 article-title: Stress sensitization in schizophrenia publication-title: Ann N Y Acad Sci – volume: 61 start-page: 197 year: 1999 end-page: 204 ident: bib36 article-title: Burnout, perceived stress, and cortisol responses to awakening publication-title: Psychosom Med – volume: 323 start-page: 1336 year: 2001 end-page: 1338 ident: bib53 article-title: Incidence of schizophrenia in ethnic minorities in London: Ecological study into interactions with environment publication-title: BMJ – volume: 6 start-page: 73 year: 2004 end-page: 78 ident: bib14 article-title: Effect of stress on prefrontal cortex function publication-title: Neurotox Res – volume: 28 start-page: 916 year: 2003 end-page: 931 ident: bib40 article-title: Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change publication-title: Psychoneuroendocrinology – volume: 58 start-page: 105 year: 2005 end-page: 110 ident: bib7 article-title: Subtle fluctuations in psychotic phenomena as functional states of abnormal dopamine reactivity in individuals at risk publication-title: Biol Psychiatry – volume: 147 start-page: 79 year: 2006 end-page: 89 ident: bib42 article-title: An automated method for the extraction of regional data from PET images publication-title: Psychiatry Res – volume: 32 start-page: 37 year: 1999 end-page: 43 ident: bib54 article-title: Maternal deprivation of neonatal rats produces enduring changes in dopamine function publication-title: Synapse – volume: 63 start-page: 234 year: 2008 end-page: 240 ident: bib33 article-title: Deactivation of the limbic system during acute psychosocial stress: Evidence from positron emission tomography and functional magnetic resonance imaging studies publication-title: Biol Psychiatry – volume: 16 start-page: 223 year: 1991 end-page: 244 ident: bib49 article-title: Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity publication-title: Brain Res Brain Res Rev – volume: 474 start-page: 498 year: 2011 end-page: 501 ident: bib35 article-title: City living and urban upbringing affect neural social stress processing in humans publication-title: Nature – volume: 22 start-page: 545 year: 2000 end-page: 550 ident: bib17 article-title: Effects of acute metabolic stress on striatal dopamine release in healthy volunteers publication-title: Neuropsychopharmacology – volume: 48 start-page: 4153 year: 2005 end-page: 4160 ident: bib21 article-title: Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography publication-title: J Med Chem – volume: 27 start-page: 563 year: 2001 end-page: 570 ident: bib30 article-title: Pre-onset detection and intervention research in schizophrenia psychoses: Current estimates of benefit and risk publication-title: Schizophr Bull – volume: 86 start-page: 103 year: 1977 end-page: 126 ident: bib4 article-title: Vulnerability—a new view of schizophrenia publication-title: J Abnorm Psychol – volume: 52 start-page: 1655 year: 1989 end-page: 1658 ident: bib12 article-title: Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex publication-title: J Neurochem – volume: 181 start-page: 130 year: 2010 end-page: 135 ident: bib15 article-title: Increased left striatal dopamine transmission in unaffected siblings of schizophrenia patients in response to acute metabolic stress publication-title: Psychiatry Res – volume: 370 start-page: 319 year: 2007 end-page: 328 ident: bib2 article-title: Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review publication-title: Lancet – volume: 39 start-page: 904 year: 1998 end-page: 911 ident: bib44 article-title: Correction for partial volume effects in PET: Principle and validation publication-title: J Nucl Med – volume: 20 start-page: 423 year: 2000 ident: 10.1016/j.biopsych.2011.10.009_bib20 article-title: Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review publication-title: J Cereb Blood Flow Metab doi: 10.1097/00004647-200003000-00001 – volume: 66 start-page: 13 year: 2009 ident: 10.1016/j.biopsych.2011.10.009_bib50 article-title: Elevated striatal dopamine function linked to prodromal signs of schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2008.514 – volume: 54 start-page: 264 year: 2011 ident: 10.1016/j.biopsych.2011.10.009_bib26 article-title: Imaging dopamine receptors in humans with [11C]-(+)-PHNO: Dissection of D3 signal and anatomy publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.06.044 – volume: 29 start-page: 703 year: 2003 ident: 10.1016/j.biopsych.2011.10.009_bib28 article-title: Prodromal assessment with the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive validity, inter-rater reliability, and training to reliability publication-title: Schizophr Bull doi: 10.1093/oxfordjournals.schbul.a007040 – volume: 31 start-page: 371 year: 2000 ident: 10.1016/j.biopsych.2011.10.009_bib47 article-title: The role of endogenous sensitization in the pathophysiology of schizophrenia: Implications from recent brain imaging studies publication-title: Brain Res Brain Res Rev doi: 10.1016/S0165-0173(99)00054-5 – volume: 27 start-page: 563 year: 2001 ident: 10.1016/j.biopsych.2011.10.009_bib30 article-title: Pre-onset detection and intervention research in schizophrenia psychoses: Current estimates of benefit and risk publication-title: Schizophr Bull doi: 10.1093/oxfordjournals.schbul.a006896 – volume: 147 start-page: 79 year: 2006 ident: 10.1016/j.biopsych.2011.10.009_bib42 article-title: An automated method for the extraction of regional data from PET images publication-title: Psychiatry Res doi: 10.1016/j.pscychresns.2006.01.011 – volume: 33 start-page: 2033 year: 2008 ident: 10.1016/j.biopsych.2011.10.009_bib18 article-title: Stress–induced dopamine release in humans at risk of psychosis: A [11C]raclopride PET study publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301597 – volume: 159 start-page: 863 year: 2002 ident: 10.1016/j.biopsych.2011.10.009_bib29 article-title: Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: Preliminary evidence of interrater reliability and predictive validity publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.159.5.863 – volume: 22 start-page: 545 year: 2000 ident: 10.1016/j.biopsych.2011.10.009_bib17 article-title: Effects of acute metabolic stress on striatal dopamine release in healthy volunteers publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(99)00153-0 – volume: 67 start-page: 275 year: 2010 ident: 10.1016/j.biopsych.2011.10.009_bib57 article-title: Dopamine type 2/3 receptor availability in the striatum and social status in human volunteers publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2009.07.037 – volume: 60 start-page: 124 year: 2006 ident: 10.1016/j.biopsych.2011.10.009_bib19 article-title: Is psychological stress in man associated with increased striatal dopamine levels? publication-title: Synapse doi: 10.1002/syn.20282 – volume: 63 start-page: 378 year: 2009 ident: 10.1016/j.biopsych.2011.10.009_bib24 article-title: Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain—a comparative PET study with [11C]raclopride and [11C]MNPA publication-title: Synapse doi: 10.1002/syn.20615 – volume: 13 start-page: 289 year: 2010 ident: 10.1016/j.biopsych.2011.10.009_bib59 article-title: Imaging the D3 receptor in humans in vivo using [11C](+)-PHNO positron emission tomography (PET) publication-title: Int J Neuropsychopharmacol doi: 10.1017/S1461145710000088 – volume: 1113 start-page: 276 year: 2007 ident: 10.1016/j.biopsych.2011.10.009_bib6 article-title: Stress sensitization in schizophrenia publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1391.013 – year: 2011 ident: 10.1016/j.biopsych.2011.10.009_bib60 article-title: Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans [published online ahead of print August 31] publication-title: J Cereb Blood Flow Metab – volume: 68 start-page: 392 year: 2010 ident: 10.1016/j.biopsych.2011.10.009_bib25 article-title: Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.04.038 – volume: 52 start-page: 1 year: 1979 ident: 10.1016/j.biopsych.2011.10.009_bib38 article-title: A parental bonding instrument publication-title: Br J Med Psychology doi: 10.1111/j.2044-8341.1979.tb02487.x – volume: 35 start-page: 91 year: 2010 ident: 10.1016/j.biopsych.2011.10.009_bib58 article-title: Human hypothalamus-pituitary-adrenal axis responses to acute psychosocial stress in laboratory settings publication-title: Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2010.01.010 – volume: 181 start-page: 130 year: 2010 ident: 10.1016/j.biopsych.2011.10.009_bib15 article-title: Increased left striatal dopamine transmission in unaffected siblings of schizophrenia patients in response to acute metabolic stress publication-title: Psychiatry Res doi: 10.1016/j.pscychresns.2009.10.002 – volume: 323 start-page: 1336 year: 2001 ident: 10.1016/j.biopsych.2011.10.009_bib53 article-title: Incidence of schizophrenia in ethnic minorities in London: Ecological study into interactions with environment publication-title: BMJ doi: 10.1136/bmj.323.7325.1336 – volume: 23 start-page: 285 year: 2003 ident: 10.1016/j.biopsych.2011.10.009_bib41 article-title: Imaging human mesolimbic dopamine transmission with positron emission tomography publication-title: J Cereb Blood Flow Metab doi: 10.1097/01.WCB.0000048520.34839.1A – volume: 86 start-page: 103 year: 1977 ident: 10.1016/j.biopsych.2011.10.009_bib4 article-title: Vulnerability—a new view of schizophrenia publication-title: J Abnorm Psychol doi: 10.1037/0021-843X.86.2.103 – volume: 32 start-page: 37 year: 1999 ident: 10.1016/j.biopsych.2011.10.009_bib54 article-title: Maternal deprivation of neonatal rats produces enduring changes in dopamine function publication-title: Synapse doi: 10.1002/(SICI)1098-2396(199904)32:1<37::AID-SYN5>3.0.CO;2-4 – volume: 58 start-page: 105 year: 2005 ident: 10.1016/j.biopsych.2011.10.009_bib7 article-title: Subtle fluctuations in psychotic phenomena as functional states of abnormal dopamine reactivity in individuals at risk publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2005.02.012 – volume: 6 start-page: 73 year: 2004 ident: 10.1016/j.biopsych.2011.10.009_bib14 article-title: Effect of stress on prefrontal cortex function publication-title: Neurotox Res doi: 10.1007/BF03033299 – volume: 16 start-page: 223 year: 1991 ident: 10.1016/j.biopsych.2011.10.009_bib49 article-title: Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity publication-title: Brain Res Brain Res Rev doi: 10.1016/0165-0173(91)90007-U – volume: 46 start-page: 56 year: 1999 ident: 10.1016/j.biopsych.2011.10.009_bib48 article-title: Increased dopamine transmission in schizophrenia: relationship to illness phases publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(99)00067-0 – volume: 42 start-page: 211 year: 1998 ident: 10.1016/j.biopsych.2011.10.009_bib46 article-title: Imaging dopamine transmission in schizophrenia publication-title: Q J Nucl Med – volume: 60 start-page: 485 year: 2006 ident: 10.1016/j.biopsych.2011.10.009_bib61 article-title: Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo publication-title: Synapse doi: 10.1002/syn.20325 – volume: 13 start-page: 721 year: 2001 ident: 10.1016/j.biopsych.2011.10.009_bib8 article-title: Developmental changes in cortisol secretion in normal and at-risk youth publication-title: Dev Psychopathol doi: 10.1017/S0954579401003169 – volume: 474 start-page: 498 year: 2011 ident: 10.1016/j.biopsych.2011.10.009_bib35 article-title: City living and urban upbringing affect neural social stress processing in humans publication-title: Nature doi: 10.1038/nature10190 – volume: 48 start-page: 1121 year: 2000 ident: 10.1016/j.biopsych.2011.10.009_bib10 article-title: Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(00)01052-0 – volume: 52 start-page: 188 year: 2004 ident: 10.1016/j.biopsych.2011.10.009_bib22 article-title: In vivo vulnerability to competition by endogenous dopamine: Comparison of the D2 receptor agonist radiotracer (–)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride publication-title: Synapse doi: 10.1002/syn.20013 – volume: 24 start-page: 2825 year: 2004 ident: 10.1016/j.biopsych.2011.10.009_bib16 article-title: Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: A positron emission tomography study using [11C]raclopride publication-title: J Neurosci doi: 10.1523/JNEUROSCI.3422-03.2004 – volume: 30 start-page: 319 year: 2005 ident: 10.1016/j.biopsych.2011.10.009_bib32 article-title: The Montreal Imaging Stress Task: Using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain publication-title: J Psychiatry Neurosci – volume: 61 start-page: 197 year: 1999 ident: 10.1016/j.biopsych.2011.10.009_bib36 article-title: Burnout, perceived stress, and cortisol responses to awakening publication-title: Psychosom Med doi: 10.1097/00006842-199903000-00012 – volume: 65 start-page: 28 year: 2008 ident: 10.1016/j.biopsych.2011.10.009_bib27 article-title: Prediction of psychosis in youth at high clinical risk: A multisite longitudinal study in North America publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2007.3 – volume: 39 start-page: 904 year: 1998 ident: 10.1016/j.biopsych.2011.10.009_bib44 article-title: Correction for partial volume effects in PET: Principle and validation publication-title: J Nucl Med – volume: 29 start-page: 207 year: 2011 ident: 10.1016/j.biopsych.2011.10.009_bib11 article-title: Developmental pathology, dopamine, stress and schizophrenia publication-title: Int J Dev Neurosci doi: 10.1016/j.ijdevneu.2010.08.002 – volume: 5 start-page: 169 year: 2002 ident: 10.1016/j.biopsych.2011.10.009_bib56 article-title: Social dominance in monkeys: Dopamine D2 receptors and cocaine self-administration publication-title: Nat Neurosci doi: 10.1038/nn798 – volume: 13 start-page: 358 year: 1999 ident: 10.1016/j.biopsych.2011.10.009_bib5 article-title: Dopamine as the wind of the psychotic fire: New evidence from brain imaging studies publication-title: J Psychopharmacol doi: 10.1177/026988119901300405 – volume: 48 start-page: 4153 year: 2005 ident: 10.1016/j.biopsych.2011.10.009_bib21 article-title: Radiosynthesis and evaluation of [11C]-(+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a potential radiotracer for in vivo imaging of the dopamine D2 high-affinity state with positron emission tomography publication-title: J Med Chem doi: 10.1021/jm050155n – volume: 16 start-page: 885 year: 2011 ident: 10.1016/j.biopsych.2011.10.009_bib51 article-title: Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: A PET study publication-title: Mol Psychiatry doi: 10.1038/mp.2011.20 – volume: 370 start-page: 319 year: 2007 ident: 10.1016/j.biopsych.2011.10.009_bib2 article-title: Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review publication-title: Lancet doi: 10.1016/S0140-6736(07)61162-3 – volume: 162 start-page: 12 year: 2005 ident: 10.1016/j.biopsych.2011.10.009_bib1 article-title: Schizophrenia and migration: A meta-analysis and review publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.162.1.12 – volume: 602 start-page: 169 year: 1993 ident: 10.1016/j.biopsych.2011.10.009_bib13 article-title: Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration publication-title: Brain Res doi: 10.1016/0006-8993(93)90260-T – volume: 50 start-page: 541 year: 1993 ident: 10.1016/j.biopsych.2011.10.009_bib9 article-title: Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1993.01820190043005 – year: 2007 ident: 10.1016/j.biopsych.2011.10.009_bib3 article-title: D3 and D2 components of ex vivo regional (+)-PHNO brain binding in wild-type and knock-out mice publication-title: SNM 113P-b – year: 1977 ident: 10.1016/j.biopsych.2011.10.009_bib37 – volume: 43 start-page: 683 year: 1992 ident: 10.1016/j.biopsych.2011.10.009_bib39 article-title: Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement publication-title: J Steroid Biochem Mol Biol doi: 10.1016/0960-0760(92)90294-S – volume: 27 start-page: 857 year: 2007 ident: 10.1016/j.biopsych.2011.10.009_bib43 article-title: Positron emission tomography quantification of [11C]-(+)-PHNO binding in the human brain publication-title: J Cereb Blood Flow Metab doi: 10.1038/sj.jcbfm.9600411 – volume: 97 start-page: 1089 year: 2006 ident: 10.1016/j.biopsych.2011.10.009_bib23 article-title: Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography publication-title: J Neurochem doi: 10.1111/j.1471-4159.2006.03840.x – volume: 13 start-page: 261 year: 1987 ident: 10.1016/j.biopsych.2011.10.009_bib31 article-title: The positive and negative syndrome scale (PANSS) for schizophrenia publication-title: Schizophr Bull doi: 10.1093/schbul/13.2.261 – volume: 28 start-page: 916 year: 2003 ident: 10.1016/j.biopsych.2011.10.009_bib40 article-title: Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change publication-title: Psychoneuroendocrinology doi: 10.1016/S0306-4530(02)00108-7 – volume: 10 start-page: 61 year: 1994 ident: 10.1016/j.biopsych.2011.10.009_bib55 article-title: Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition publication-title: Neuropsychopharmacology doi: 10.1038/npp.1994.8 – year: 2007 ident: 10.1016/j.biopsych.2011.10.009_bib34 article-title: Cross-sensitization between stimulants and stress in humans: Behavioral and neurochemical correlates – volume: 63 start-page: 234 year: 2008 ident: 10.1016/j.biopsych.2011.10.009_bib33 article-title: Deactivation of the limbic system during acute psychosocial stress: Evidence from positron emission tomography and functional magnetic resonance imaging studies publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2007.04.041 – volume: 155 start-page: 761 year: 1998 ident: 10.1016/j.biopsych.2011.10.009_bib45 article-title: Increased striatal dopamine transmission in schizophrenia: Confirmation in a second cohort publication-title: Am J Psychiatry – volume: 67 start-page: 231 year: 2010 ident: 10.1016/j.biopsych.2011.10.009_bib52 article-title: Increased synaptic dopamine function in associative regions of the striatum in schizophrenia publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2010.10 – volume: 52 start-page: 1655 year: 1989 ident: 10.1016/j.biopsych.2011.10.009_bib12 article-title: Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex publication-title: J Neurochem doi: 10.1111/j.1471-4159.1989.tb09224.x |
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| Snippet | A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential etiologic factor... Background A pathologic response to common life stressors, in which a hyperresponsive dopaminergic system is thought to play a key role, is a potential... |
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| SubjectTerms | Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Brain Mapping - methods Dopamine Dopamine - secretion Female Humans Hydrocortisone - metabolism Image Processing, Computer-Assisted - methods Male Medical sciences neuroimaging positron emission tomography Positron-Emission Tomography - methods prodrome Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotic Disorders - complications Psychotic Disorders - diagnostic imaging Psychotic Disorders - metabolism Saliva - metabolism Schizophrenia Schizophrenia - complications Schizophrenia - diagnostic imaging Schizophrenia - metabolism stress Stress, Psychological - complications Stress, Psychological - metabolism Young Adult |
| Title | Increased Stress-Induced Dopamine Release in Psychosis |
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