Impact of the cultivation strategy on resveratrol production from glucose in engineered Corynebacterium glutamicum

• Published in: Journal of biotechnology Vol. 265; pp. 70 - 75
• Main Authors: Braga, Adelaide, Oliveira, Joana, Silva, Rita, Ferreira, Patricia, Rocha, Isabel, Kallscheuer, Nicolai, Marienhagen, Jan, Faria, Nuno
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.01.2018; Elsevier
• Subjects: adenosine triphosphate; antioxidants; Batch; batch fermentation; biomass; bioreactors; cerulenin; Corynebacterium glutamicum; culture flasks; dietary supplements; fatty-acid synthase; Fed-batch; flavonoids; glucose; humans; ingredients; malonyl coenzyme A; microorganisms; Oxidation; oxygen; p-coumaric acid; polyphenols; Resveratrol; Science & Technology; specific growth rate; Oxidation; Fed-batch; Batch; Corynebacterium glutamicum; Resveratrol

•Resveratrol production in C. glutamicum in defined medium starting from glucose.•Production was achieved in absence of p-coumaric acid and cerulenin.•Optimization of cultivation conditions in batch and fed-batch mode.•Product degradation was observed in presence of high oxygen levels.•Resveratrol d...