The influence of NK cell-mediated ADCC: Structure and expression of the CD16 molecule differ among FcγRIIIa-V158F genotypes in healthy Japanese subjects

• Published in: Human immunology Vol. 77; no. 2; pp. 165 - 171
• Main Authors: Oboshi, Wataru, Watanabe, Toru, Matsuyama, Yuumi, Kobara, Ayana, Yukimasa, Nobuyasu, Ueno, Ichiro, Aki, Kensaku, Tada, Tomoki, Hosoi, Eiji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2016
• Subjects: Adolescent; Adult; Allergy and Immunology; Antibody-Dependent Cell Cytotoxicity - genetics; Antibody-Dependent Cell Cytotoxicity - immunology; Antibody-dependent cellular cytotoxicity (ADCC); CD16 molecule; FcγRIIIa-V158F polymorphism; Female; Gene Expression Regulation; Gene Frequency; Genotype; Humans; Japan; Killer Cells, Natural - immunology; Male; NK cells; Protein Binding - genetics; Receptors, IgG - chemistry; Receptors, IgG - genetics; Rituximab-binding affinity; Single nucleotide polymorphisms (SNPs); Young Adult; CD16 molecule; Single nucleotide polymorphisms (SNPs); NK cells; Rituximab-binding affinity; Antibody-dependent cellular cytotoxicity (ADCC); FcγRIIIa-V158F polymorphism

NK cells express the CD16 (FcγRIIIa) receptor, which mediates antibody-dependent cellular cytotoxicity (ADCC), on their cell surface. Therefore, ADCC activity may be influenced by qualitative or quantitative changes in the CD16 molecule on NK cells. Responses to NK cell-mediated ADCC have been shown...