Regulation of inflammation by the antioxidant haem oxygenase 1

• Published in: Nature reviews. Immunology Vol. 21; no. 7; pp. 411 - 425
• Main Authors: Campbell, Nicole K., Fitzgerald, Hannah K., Dunne, Aisling
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2021; Nature Publishing Group
• Subjects: 631/250/256; 631/443/319; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - immunology; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Antioxidants; Antioxidants - metabolism; Autoimmune diseases; Biomedical and Life Sciences; Biomedicine; Carbon monoxide; Carbon Monoxide - metabolism; Care and treatment; Dendritic Cells - immunology; Dendritic Cells - metabolism; Development and progression; Enzyme Induction - drug effects; Gene Expression Regulation, Enzymologic; Health aspects; Heme; Heme oxygenase (decyclizing); Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - immunology; Heme Oxygenase-1 - metabolism; Humans; Immunology; Immunomodulation; Inflammation; Inflammation - drug therapy; Inflammation - enzymology; Inflammation - immunology; Inflammatory Bowel Diseases - drug therapy; Inflammatory Bowel Diseases - enzymology; Inflammatory Bowel Diseases - immunology; Iron; Macrophages - immunology; Macrophages - metabolism; Medical treatment; Metabolism; Models, Biological; Multiple Sclerosis - drug therapy; Multiple Sclerosis - enzymology; Multiple Sclerosis - immunology; Oxidoreductases; Oxygenase; Physiological aspects; Phytochemicals - therapeutic use; Pneumonia - drug therapy; Pneumonia - enzymology; Pneumonia - immunology; Psoriasis - drug therapy; Psoriasis - enzymology; Psoriasis - immunology; Review Article; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Transplantation Immunology; Ireland

Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of haem, is primarily considered an antioxidant, and has long been overlooked by immunologists. However, research over the past two decades in particular has demonstrated that HO-1 also exhibits numerous anti-inflammatory pro...