Influenza Virus H1N1pdm09 Infections in the Young and Old: Evidence of Greater Antibody Diversity and Affinity for the Hemagglutinin Globular Head Domain (HA1 Domain) in the Elderly than in Young Adults and Children

• Published in: Journal of Virology Vol. 86; no. 10; pp. 5515 - 5522
• Main Authors: Verma, Nitin, Dimitrova, Milena, Carter, Donald M., Crevar, Corey J., Ross, Ted M., Golding, Hana, Khurana, Surender
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.05.2012
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Animals; antibodies; Antibodies, Viral; Antibodies, Viral - immunology; Antibody Affinity; Antibody Diversity; avian influenza; bacteriophages; Biological and medical sciences; cell-mediated immunity; chemistry; Child; Child, Preschool; children; dissociation; elderly; Female; Ferrets; Fundamental and applied biological sciences. Psychology; genes; genetics; hemagglutination; hemagglutination inhibition test; Hemagglutinin Glycoproteins, Influenza Virus; Hemagglutinin Glycoproteins, Influenza Virus - chemistry; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - immunology; hemagglutinins; human influenza; Humans; immunology; Infant; Influenza A virus; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H1N1 Subtype - chemistry; Influenza A Virus, H1N1 Subtype - genetics; Influenza A Virus, H1N1 Subtype - immunology; Influenza virus; Influenza, Human; Influenza, Human - immunology; Influenza, Human - virology; Male; Microbiology; Middle Aged; Miscellaneous; morbidity; mortality; Mustela; pandemic; Pathogenesis and Immunity; peptide libraries; plasma cells; Protein Structure, Tertiary; sialidase; surface plasmon resonance; urea; Virology; Young Adult; young adults; Human; Infection; Virus; Antibody; Hemagglutinin; Viral disease; Orthomyxoviridae; Child; Influenzavirus; Elderly
• ISSN: 0022-538X; 1098-5514; 1098-5514
• DOI: 10.1128/JVI.07085-11

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