PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 296; no. 2; pp. H442 - H452
• Main Authors: Thomas, James A, Deaton, Rebecca A, Hastings, Nicole E, Shang, Yueting, Moehle, Christopher W, Eriksson, Ulf, Topouzis, Stavros, Wamhoff, Brian R, Blackman, Brett R, Owens, Gary K
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.02.2009
• Subjects: Actins - metabolism; Animals; Apolipoproteins E - deficiency; Apolipoproteins E - genetics; Arteriosclerosis; Atherosclerosis - metabolism; Atherosclerosis - physiopathology; Calcium-Binding Proteins - metabolism; Calponins; Cells; Cells, Cultured; Disease Models, Animal; Endothelial Cells - metabolism; ets-Domain Protein Elk-1 - metabolism; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases - metabolism; Genes; Genes, Reporter; Genotype & phenotype; Humans; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors - metabolism; Lymphokines - genetics; Lymphokines - metabolism; Membranes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins - metabolism; Muscle Proteins - metabolism; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myosin Heavy Chains - metabolism; Phenotype; Phosphorylation; Platelet-Derived Growth Factor - genetics; Platelet-Derived Growth Factor - metabolism; Promoter Regions, Genetic; Protein Kinase Inhibitors - pharmacology; Protein Multimerization; Proteins; Rats; Receptor, Platelet-Derived Growth Factor beta - genetics; Receptor, Platelet-Derived Growth Factor beta - metabolism; Recombinant Proteins - metabolism; Regional Blood Flow; Ribonucleic acid; RNA; RNA Interference; RNA, Messenger - metabolism; RNA, Small Interfering - metabolism; Stress, Mechanical; Time Factors; Up-Regulation

Departments of 1 Molecular Physiology and Biological Physics, 2 Biomedical Engineering, and 3 Cardiovascular Medicine and 4 Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia; 5 Ludwig Institute for Cancer Research, Stockholm Branch, Stockholm, Sweden;...