KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting

• Published in: Cell reports (Cambridge) Vol. 16; no. 9; pp. 2373 - 2386
• Main Authors: Takeuchi, Yoshinori, Yahagi, Naoya, Aita, Yuichi, Murayama, Yuki, Sawada, Yoshikazu, Piao, Xiaoying, Toya, Naoki, Oya, Yukari, Shikama, Akito, Takarada, Ayako, Masuda, Yukari, Nishi, Makiko, Kubota, Midori, Izumida, Yoshihiko, Yamamoto, Takashi, Sekiya, Motohiro, Matsuzaka, Takashi, Nakagawa, Yoshimi, Urayama, Osamu, Kawakami, Yasushi, Iizuka, Yoko, Gotoda, Takanari, Itaka, Keiji, Kataoka, Kazunori, Nagai, Ryozo, Kadowaki, Takashi, Yamada, Nobuhiro, Lu, Yuan, Jain, Mukesh K., Shimano, Hitoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.08.2016; Elsevier
• Subjects: Animals; Cyclic AMP-Dependent Protein Kinases - genetics; Cyclic AMP-Dependent Protein Kinases - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Fasting; Genes, Reporter; Genome; Gluconeogenesis - genetics; Hepatocytes - cytology; Hepatocytes - metabolism; Kruppel-Like Transcription Factors; Lipogenesis - genetics; Liver - cytology; Liver - metabolism; Liver X Receptors - genetics; Liver X Receptors - metabolism; Luciferases - genetics; Luciferases - metabolism; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Nuclear Receptor Co-Repressor 1 - genetics; Nuclear Receptor Co-Repressor 1 - metabolism; Primary Cell Culture; Promoter Regions, Genetic; Protein Binding; Retinoid X Receptors - genetics; Retinoid X Receptors - metabolism; Signal Transduction; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; Transcriptional Activation

Hepatic lipogenesis is nutritionally regulated (i.e., downregulated during fasting and upregulated during the postprandial state) as an adaptation to the nutritional environment. While alterations in the expression level of the transcription factor SREBP-1c are known to be critical for nutritionally...