A retrospective study on molecular epidemiology trends of carbapenem resistant Enterobacteriaceae in a teaching hospital in Malaysia

• Published in: PeerJ (San Francisco, CA) Vol. 10; p. e12830
• Main Authors: Kong, Zhi Xian, N Karunakaran, Rina, Abdul Jabar, Kartini, Ponnampalavanar, Sasheela, Chong, Chun Wie, Teh, Cindy Shuan Ju
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 22.02.2022; PeerJ, Inc; PeerJ Inc
• Subjects: Antibiotics; Antimicrobial agents; Bacterial pneumonia; Beta lactamases; Carbapenem resistant Enterobacteriaceae; Carbapenem-Resistant Enterobacteriaceae - genetics; Carbapenemase; Carbapenems - pharmacology; Catheters; Colistin; Drug resistance in microorganisms; E coli; Enterobacteriaceae; Epidemiology; Ethics; Hospitalization; Hospitals, Teaching; Humans; Imipenem; Klebsiella pneumoniae; Laboratories; Malaysia; Medical research; Meropenem; Microbiology; Minimum inhibitory concentration; Molecular Biology; Molecular Epidemiology; Mortality; Nosocomial infections; Pathogens; Patients; Pneumonia; Porins; Pulse-field gel electrophoresis; Retrospective Studies; Risk factors; Software; Statistical analysis; Teaching hospitals; Thailand; Malaysia; Thailand; United States > US; Indonesia; Carbapenem resistant Enterobacteriaceae; Carbapenemase; Pulse-field gel electrophoresis; Epidemiology; Porins

Carbapenem resistant (CRE) has rapidly disseminated worldwide and has become a global threat to the healthcare system due to its resistance towards "last line" antibiotics. This study aimed to investigate the prevalence of CRE and the resistance mechanism as well as the risk factors associ...