Self-illuminating quantum dot conjugates for in vivo imaging

• Published in: Nature biotechnology Vol. 24; no. 3; pp. 339 - 343
• Main Authors: So, Min-Kyung, Xu, Chenjie, Loening, Andreas M, Gambhir, Sanjiv S, Rao, Jianghong
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2006; Nature; Nature Publishing Group
• Subjects: Agriculture; Animals; Bioinformatics; Biological and medical sciences; Bioluminescence; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Diagnostic Imaging; Diverse techniques; Energy Transfer; Enzymes; Fluorescence; Fundamental and applied biological sciences. Psychology; letter; Life Sciences; Luciferases - genetics; Luciferases - metabolism; Luminescent Measurements - methods; Mice; Mice, Nude; Microscopy, Fluorescence; Molecular and cellular biology; Quantum Dots; Renilla reniformis; Resonance; Scientific imaging; Semiconductors; Sensitivity and Specificity; Bioluminescence; Quantum dot; Semiconductor materials; Enzyme; Luciferase; Fluorescence; Imagery; In vivo; Tissue; Resonant energy transfer; Animal; Oxidoreductases; Conjugated compound

Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo 1 , 2 , 3 , 4 , 5 . However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofl...