Self-illuminating quantum dot conjugates for in vivo imaging
Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo 1 , 2 , 3 , 4 , 5 . However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofl...
Saved in:
| Published in | Nature biotechnology Vol. 24; no. 3; pp. 339 - 343 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.03.2006
Nature Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Fluorescent semiconductor quantum dots hold great potential for molecular imaging
in vivo
1
,
2
,
3
,
4
,
5
. However, the utility of existing quantum dots for
in vivo
imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofluorescence background and a paucity of excitation light at nonsuperficial locations. Here we present quantum dot conjugates that luminesce by bioluminescence resonance energy transfer in the absence of external excitation. The conjugates are prepared by coupling carboxylate-presenting quantum dots to a mutant of the bioluminescent protein
Renilla reniformis
luciferase. We show that the conjugates emit long-wavelength (from red to near-infrared) bioluminescent light in cells and in animals, even in deep tissues, and are suitable for multiplexed
in vivo
imaging. Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an
in vivo
signal-to-background ratio of > 10
3
for 5 pmol of conjugate. |
|---|---|
| AbstractList | Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo. However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofluorescence background and a paucity of excitation light at nonsuperficial locations. Here we present quantum dot conjugates that luminesce by bioluminescence resonance energy transfer in the absence of external excitation. The conjugates are prepared by coupling carboxylate-presenting quantum dots to a mutant of the bioluminescent protein Renilla reniformis luciferase. We show that the conjugates emit long-wavelength (from red to near-infrared) bioluminescent light in cells and in animals, even in deep tissues, and are suitable for multiplexed in vivo imaging. Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10(3) for 5 pmol of conjugate.Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo. However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofluorescence background and a paucity of excitation light at nonsuperficial locations. Here we present quantum dot conjugates that luminesce by bioluminescence resonance energy transfer in the absence of external excitation. The conjugates are prepared by coupling carboxylate-presenting quantum dots to a mutant of the bioluminescent protein Renilla reniformis luciferase. We show that the conjugates emit long-wavelength (from red to near-infrared) bioluminescent light in cells and in animals, even in deep tissues, and are suitable for multiplexed in vivo imaging. Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10(3) for 5 pmol of conjugate. Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo. However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofluorescence background and a paucity of excitation light at nonsuperficial locations. Here we present quantum dot conjugates that luminesce by bioluminescence resonance energy transfer in the absence of external excitation. The conjugates are prepared by coupling carboxylate-presenting quantum dots to a mutant of the bioluminescent protein Renilla reniformis luciferase. We show that the conjugates emit long-wavelength (from red to near-infrared) bioluminescent light in cells and in animals, even in deep tissues, and are suitable for multiplexed in vivo imaging. Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10(3) for 5 pmol of conjugate. Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo 1 , 2 , 3 , 4 , 5 . However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofluorescence background and a paucity of excitation light at nonsuperficial locations. Here we present quantum dot conjugates that luminesce by bioluminescence resonance energy transfer in the absence of external excitation. The conjugates are prepared by coupling carboxylate-presenting quantum dots to a mutant of the bioluminescent protein Renilla reniformis luciferase. We show that the conjugates emit long-wavelength (from red to near-infrared) bioluminescent light in cells and in animals, even in deep tissues, and are suitable for multiplexed in vivo imaging. Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10 3 for 5 pmol of conjugate. Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo super(1, ) super(2, ) super(3, ) super(4, ) super(5). However, the utility of existing quantum dots for in vivo imaging is limited because they require excitation from external illumination sources to fluoresce, which results in a strong autofluorescence background and a paucity of excitation light at nonsuperficial locations. Here we present quantum dot conjugates that luminesce by bioluminescence resonance energy transfer in the absence of external excitation. The conjugates are prepared by coupling carboxylate-presenting quantum dots to a mutant of the bioluminescent protein Renilla reniformis luciferase. We show that the conjugates emit long- wavelength (from red to near-infrared) bioluminescent light in cells and in animals, even in deep tissues, and are suitable for multiplexed in vivo imaging. Compared with existing quantum dots, self-illuminating quantum dot conjugates have greatly enhanced sensitivity in small animal imaging, with an in vivo signal-to-background ratio of > 10 super(3) for 5 pmol of conjugate. |
| Audience | Academic |
| Author | Rao, Jianghong Gambhir, Sanjiv S Xu, Chenjie Loening, Andreas M So, Min-Kyung |
| Author_xml | – sequence: 1 givenname: Min-Kyung surname: So fullname: So, Min-Kyung organization: Department of Radiology & Bio-X Program, Molecular Imaging Program at Stanford, Stanford University – sequence: 2 givenname: Chenjie surname: Xu fullname: Xu, Chenjie organization: Department of Radiology & Bio-X Program, Molecular Imaging Program at Stanford, Stanford University – sequence: 3 givenname: Andreas M surname: Loening fullname: Loening, Andreas M organization: Department of Radiology & Bio-X Program, Molecular Imaging Program at Stanford, Stanford University, Department of Bioengineering, Stanford University – sequence: 4 givenname: Sanjiv S surname: Gambhir fullname: Gambhir, Sanjiv S organization: Department of Radiology & Bio-X Program, Molecular Imaging Program at Stanford, Stanford University, Department of Bioengineering, Stanford University – sequence: 5 givenname: Jianghong surname: Rao fullname: Rao, Jianghong email: jrao@stanford.edu organization: Department of Radiology & Bio-X Program, Molecular Imaging Program at Stanford, Stanford University, Biophysics Program, Stanford University |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17585399$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16501578$$D View this record in MEDLINE/PubMed |
| BookMark | eNqN0ltrFDEUAOAgFXtR_AcyCN4epiYzkxv4UoqXQqFg1dchkz0ZsswkbZIp-u89ZVeWLoKShySHLyHn5ByTgxADEPKc0VNGW_U-DIUxpR6RI8Y7UTOhxQGuqZI1ZVwckuOc15RS0QnxhBwywTEs1RH5cA2Tq_00LbMPpvgwVreLCWWZq1UslY1hvYymQK5cTJUP1Z2_i5WfzYj0KXnszJTh2XY-Id8_ffx2_qW-vPp8cX52WVsu21K3nRW8A6Ncs6KDAula1fChFUA50E5wI5S1QjgNijLp2KBh4KBbxSnuZXtCXm_uvUnxdoFc-tlnC9NkAsQl90LKRmpN_wmZ7hC2GuHLPbiOSwqYRN80TUul5ALR6QaNZoLeBxdLMhbHCmaPlQHnMX7GNJa-wYrigXcPDqAp8LOMZsm5v7j--v_26sdD-2L72mWYYdXfJPyA9Kv_840IXm2BydZMLplgfd45yRVv9X3abzbOpphzArcjtL9vpH7bSCjrPWl9wf7AVybjp7_4txuf8cYwQtoVdJ_-BvAm0lM |
| CODEN | NABIF9 |
| CitedBy_id | crossref_primary_10_1016_j_colsurfb_2014_12_011 crossref_primary_10_1088_0957_4484_23_31_315101 crossref_primary_10_1002_mabi_201800301 crossref_primary_10_1002_smll_202100045 crossref_primary_10_1038_srep34311 crossref_primary_10_1126_sciadv_aba3009 crossref_primary_10_2217_nnm_11_76 crossref_primary_10_1016_j_cclet_2009_04_020 crossref_primary_10_1364_OL_39_001756 crossref_primary_10_1016_j_bbrc_2008_04_159 crossref_primary_10_1021_acs_nanolett_7b04369 crossref_primary_10_1111_and_14589 crossref_primary_10_1002_adfm_200700439 crossref_primary_10_1007_s00216_006_0541_z crossref_primary_10_1016_j_ccr_2022_214726 crossref_primary_10_1002_chem_200900344 crossref_primary_10_1002_anie_202116174 crossref_primary_10_1021_cm070798m crossref_primary_10_1021_nn901404h crossref_primary_10_1002_anie_201107919 crossref_primary_10_1002_asia_201000873 crossref_primary_10_3389_fbioe_2023_1191509 crossref_primary_10_3724_SP_J_1249_2013_05518 crossref_primary_10_1038_nmeth1070 crossref_primary_10_3727_215517916X693159 crossref_primary_10_1016_j_ddmod_2007_07_001 crossref_primary_10_1021_nn102762f crossref_primary_10_3390_s6080925 crossref_primary_10_1039_b925477c crossref_primary_10_1016_j_bios_2011_09_002 crossref_primary_10_1016_j_comnet_2009_08_001 crossref_primary_10_1088_0957_4484_20_41_415103 crossref_primary_10_1002_advs_201700548 crossref_primary_10_3389_fbioe_2019_00326 crossref_primary_10_1038_nbt_3987 crossref_primary_10_1021_cb200135e crossref_primary_10_1021_acs_chemmater_7b00108 crossref_primary_10_1016_j_bios_2009_04_013 crossref_primary_10_1002_anie_201801226 crossref_primary_10_1007_s12274_016_1342_0 crossref_primary_10_1021_ja5053158 crossref_primary_10_1021_nl071114c crossref_primary_10_2217_17435889_2_6_951 crossref_primary_10_1038_srep02825 crossref_primary_10_1007_s00604_019_3659_3 crossref_primary_10_1063_1_4862232 crossref_primary_10_1039_C8TB00614H crossref_primary_10_1039_C9RA07011G crossref_primary_10_1002_smll_201200109 crossref_primary_10_1517_17530059_2_3_315 crossref_primary_10_1557_PROC_0950_D04_09 crossref_primary_10_1039_c3tb20202j crossref_primary_10_1088_0957_4484_25_49_495606 crossref_primary_10_1021_acs_analchem_3c03305 crossref_primary_10_1016_j_jmb_2007_09_078 crossref_primary_10_3390_polym15020405 crossref_primary_10_1007_s12975_011_0111_3 crossref_primary_10_1021_jp068920c crossref_primary_10_2174_1573413715666191126093258 crossref_primary_10_1016_j_cjac_2021_08_003 crossref_primary_10_1021_ja210162f crossref_primary_10_1007_s00216_017_0212_2 crossref_primary_10_1038_s41467_023_37827_9 crossref_primary_10_1016_j_mtchem_2024_102233 crossref_primary_10_1002_cmmi_395 crossref_primary_10_1073_pnas_1204516109 crossref_primary_10_1109_MSP_2007_904801 crossref_primary_10_1002_anie_202314468 crossref_primary_10_1007_s00216_015_8981_y crossref_primary_10_2217_nnm_12_12 crossref_primary_10_1002_wnan_139 crossref_primary_10_1016_j_spmi_2008_11_029 crossref_primary_10_1021_acs_analchem_6b04873 crossref_primary_10_1038_s41551_022_00978_z crossref_primary_10_1021_bc100256d crossref_primary_10_1021_jp710399d crossref_primary_10_1002_0471142956_cy1227s60 crossref_primary_10_1039_C6RA07368A crossref_primary_10_1002_ange_201408593 crossref_primary_10_1016_j_matchemphys_2010_03_066 crossref_primary_10_1016_j_copbio_2014_11_006 crossref_primary_10_1093_ilar_49_1_103 crossref_primary_10_1039_c0mb00328j crossref_primary_10_1002_mabi_201200267 crossref_primary_10_1016_j_bbrc_2006_07_160 crossref_primary_10_1134_S0036024422020182 crossref_primary_10_1021_ac201331r crossref_primary_10_1021_acsanm_9b01851 crossref_primary_10_1002_cphc_201600270 crossref_primary_10_1109_TNB_2009_2017321 crossref_primary_10_1021_acs_jpcc_9b10536 crossref_primary_10_1002_ejic_200800332 crossref_primary_10_1149_1_3138462 crossref_primary_10_1016_j_talanta_2024_126821 crossref_primary_10_1158_0008_5472_CAN_06_4623 crossref_primary_10_4155_bio_09_30 crossref_primary_10_3390_ijms21186538 crossref_primary_10_1016_j_biomaterials_2012_08_044 crossref_primary_10_1021_ja3045212 crossref_primary_10_1038_ncomms2197 crossref_primary_10_1021_nl301291g crossref_primary_10_5301_RU_2013_10620 crossref_primary_10_1039_c2cc34899c crossref_primary_10_1517_17460440902804372 crossref_primary_10_1126_sciadv_aat2953 crossref_primary_10_3390_s150613288 crossref_primary_10_1002_anie_201205151 crossref_primary_10_1039_C4RA05665E crossref_primary_10_1016_j_cej_2020_127351 crossref_primary_10_1002_ange_201107919 crossref_primary_10_1007_s11051_013_1575_8 crossref_primary_10_1039_C4RA08847F crossref_primary_10_1021_bm300796q crossref_primary_10_1111_j_1574_6976_2010_00252_x crossref_primary_10_1002_smll_200801079 crossref_primary_10_2217_ijr_10_105 crossref_primary_10_1002_chem_201400210 crossref_primary_10_1016_j_chempr_2017_05_002 crossref_primary_10_1002_jcb_24111 crossref_primary_10_1039_C2CC37883C crossref_primary_10_1007_s00216_010_3643_6 crossref_primary_10_1016_j_cbpa_2010_12_002 crossref_primary_10_1039_c2cc36099c crossref_primary_10_1021_ja311400t crossref_primary_10_1002_ange_201802889 crossref_primary_10_1166_jbn_2022_3402 crossref_primary_10_1016_j_nano_2019_04_008 crossref_primary_10_1002_jbio_201100066 crossref_primary_10_3109_09687688_2010_481640 crossref_primary_10_1002_adma_200500786 crossref_primary_10_1002_wnan_1191 crossref_primary_10_1002_ange_202116174 crossref_primary_10_1109_JSTQE_2013_2283155 crossref_primary_10_1002_cphc_200800693 crossref_primary_10_1002_cjoc_201500743 crossref_primary_10_1002_0471143030_cb2501s36 crossref_primary_10_1016_j_addr_2019_04_009 crossref_primary_10_1073_pnas_1421632111 crossref_primary_10_1039_D0TB00262C crossref_primary_10_1155_2007_68963 crossref_primary_10_1002_ange_201900594 crossref_primary_10_1016_j_jconrel_2023_02_040 crossref_primary_10_2217_nnm_10_49 crossref_primary_10_1002_bio_1011 crossref_primary_10_1002_anie_200902893 crossref_primary_10_3892_ol_2012_870 crossref_primary_10_1039_C4RA14348E crossref_primary_10_1016_j_talanta_2008_12_033 crossref_primary_10_1021_ja202639m crossref_primary_10_1016_j_nantod_2009_07_004 crossref_primary_10_1016_j_trac_2019_115750 crossref_primary_10_1021_acs_nanolett_9b02544 crossref_primary_10_1002_ange_201801226 crossref_primary_10_1039_C6TB02308H crossref_primary_10_1364_OE_18_020201 crossref_primary_10_1002_anie_201802889 crossref_primary_10_1016_j_addr_2011_09_011 crossref_primary_10_1039_C7NR05233B crossref_primary_10_1016_j_aca_2010_05_026 crossref_primary_10_1039_B813919A crossref_primary_10_1021_ja101378g crossref_primary_10_1021_nn505660r crossref_primary_10_1038_s41467_018_05113_8 crossref_primary_10_14723_tmrsj_33_795 crossref_primary_10_1002_ange_200902893 crossref_primary_10_1016_j_bios_2016_02_005 crossref_primary_10_1002_ange_200700280 crossref_primary_10_1021_nn304736j crossref_primary_10_1016_j_cclet_2010_09_016 crossref_primary_10_1088_1361_6463_ac0740 crossref_primary_10_1038_nm_3110 crossref_primary_10_1155_2012_875148 crossref_primary_10_1039_c3nr03339b crossref_primary_10_4028_www_scientific_net_AMR_266_46 crossref_primary_10_1021_jacs_6b11042 crossref_primary_10_1002_pssr_201308329 crossref_primary_10_1021_acs_chemmater_5b02870 crossref_primary_10_1039_D2CS00497F crossref_primary_10_1002_ange_202314468 crossref_primary_10_1002_anie_200700280 crossref_primary_10_1021_acs_chemmater_0c01484 crossref_primary_10_1007_s00216_024_05180_5 crossref_primary_10_1021_cbmi_4c00085 crossref_primary_10_1016_j_snb_2017_11_189 crossref_primary_10_1002_smll_201200760 crossref_primary_10_1016_j_commatsci_2010_04_010 crossref_primary_10_1021_acsabm_0c01438 crossref_primary_10_1039_C5RA01508A crossref_primary_10_1021_acs_analchem_8b04424 crossref_primary_10_1002_cnm_1164 crossref_primary_10_1016_j_biomaterials_2015_11_029 crossref_primary_10_1039_b704275b crossref_primary_10_1016_j_nantod_2008_10_009 crossref_primary_10_3390_bios9020076 crossref_primary_10_1021_acs_bioconjchem_8b00149 crossref_primary_10_1039_C0AN00429D crossref_primary_10_1634_stemcells_2006_0722 crossref_primary_10_1016_j_molmed_2010_08_006 crossref_primary_10_1002_cbic_201900149 crossref_primary_10_1021_acs_chemrev_1c00506 crossref_primary_10_1088_0957_4484_23_49_495102 crossref_primary_10_1517_17425240903167934 crossref_primary_10_1186_s12951_018_0392_8 crossref_primary_10_1007_s11426_011_4350_7 crossref_primary_10_1007_s00216_008_2215_5 crossref_primary_10_1016_j_biomaterials_2018_10_043 crossref_primary_10_1021_acs_chemrev_5b00049 crossref_primary_10_1002_ange_201205151 crossref_primary_10_1021_ja202767g crossref_primary_10_1016_j_saa_2024_124937 crossref_primary_10_1021_acs_chemrev_6b00030 crossref_primary_10_1142_S1793048007000428 crossref_primary_10_2967_jnumed_108_053561 crossref_primary_10_1007_s00216_009_2744_6 crossref_primary_10_1002_advs_201500223 crossref_primary_10_1039_D0CS00936A crossref_primary_10_1002_ange_200800169 crossref_primary_10_1021_ct500681m crossref_primary_10_1039_c2lc40181a crossref_primary_10_1002_ange_201502736 crossref_primary_10_1007_s00216_008_2435_8 crossref_primary_10_3390_bios9010042 crossref_primary_10_1016_j_copbio_2009_01_001 crossref_primary_10_1016_j_nuclcard_2006_05_012 crossref_primary_10_1016_j_jallcom_2010_08_023 crossref_primary_10_1002_cjoc_200990306 crossref_primary_10_3389_fbioe_2019_00073 crossref_primary_10_1038_nm_3323 crossref_primary_10_4028_www_scientific_net_MSF_685_114 crossref_primary_10_1016_j_biomaterials_2010_05_030 crossref_primary_10_1038_s41598_024_60536_2 crossref_primary_10_3390_cancers13112801 crossref_primary_10_1021_acs_analchem_6b04362 crossref_primary_10_1002_chem_201102096 crossref_primary_10_1021_jacs_9b05894 crossref_primary_10_1080_05704928_2017_1328428 crossref_primary_10_1111_brv_12758 crossref_primary_10_1002_cmmi_428 crossref_primary_10_1002_adma_201102313 crossref_primary_10_1021_acsami_8b07668 crossref_primary_10_1016_j_apsb_2016_01_007 crossref_primary_10_1016_j_sbsr_2014_12_001 crossref_primary_10_1016_j_dyepig_2016_12_009 crossref_primary_10_1002_anie_202007520 crossref_primary_10_1016_j_cap_2018_04_003 crossref_primary_10_1039_C4CS00294F crossref_primary_10_1021_ja410438n crossref_primary_10_1021_ar200106e crossref_primary_10_1002_macp_200900601 crossref_primary_10_1070_QEL17206 crossref_primary_10_1366_12_06948 crossref_primary_10_1038_nmeth0406_240a crossref_primary_10_3724_SP_J_1095_2014_30457 crossref_primary_10_1007_s00259_010_1452_y crossref_primary_10_1002_ange_200503873 crossref_primary_10_1016_j_trac_2019_04_011 crossref_primary_10_4048_jbc_2013_16_1_1 crossref_primary_10_1021_bc700356f crossref_primary_10_1039_C9CC07399J crossref_primary_10_1002_anie_201405849 crossref_primary_10_1039_b9nr00304e crossref_primary_10_1002_path_2421 crossref_primary_10_1002_adfm_200800753 crossref_primary_10_1021_acs_jpcc_5b11023 crossref_primary_10_1016_j_ccr_2024_216027 crossref_primary_10_3390_s90907266 crossref_primary_10_1002_ange_200906399 crossref_primary_10_1289_ehp_11566 crossref_primary_10_1007_s10404_007_0240_x crossref_primary_10_1016_j_tibtech_2017_06_002 crossref_primary_10_1186_s12951_016_0168_y crossref_primary_10_4161_cbt_12_10_17679 crossref_primary_10_1007_s00253_017_8140_9 crossref_primary_10_1021_acs_chemrev_3c00401 crossref_primary_10_3390_ijms17101704 crossref_primary_10_1002_adma_201801778 crossref_primary_10_1109_MNANO_2008_920051 crossref_primary_10_1016_j_jconrel_2022_06_013 crossref_primary_10_1039_C5NR00828J crossref_primary_10_1002_cbic_201600357 crossref_primary_10_1016_j_addr_2012_08_016 crossref_primary_10_1038_s41566_024_01387_1 crossref_primary_10_1002_adom_201900526 crossref_primary_10_1016_j_bbrc_2015_07_039 crossref_primary_10_1016_j_ejpb_2006_08_011 crossref_primary_10_1557_jmr_2014_25 crossref_primary_10_1007_s00216_008_2410_4 crossref_primary_10_1007_s00216_010_4309_0 crossref_primary_10_1007_s11051_011_0523_8 crossref_primary_10_1039_C9TB02666E crossref_primary_10_1088_0953_8984_21_39_395302 crossref_primary_10_3390_ijms21093358 crossref_primary_10_1002_lpor_201300024 crossref_primary_10_1039_B618902D crossref_primary_10_1021_am100435k crossref_primary_10_1002_bio_4373 crossref_primary_10_1002_smll_202207694 crossref_primary_10_1002_adma_200703183 crossref_primary_10_1016_j_nano_2009_04_008 crossref_primary_10_1016_j_talanta_2013_02_007 crossref_primary_10_1016_j_saa_2019_117279 crossref_primary_10_1021_acs_chemrestox_8b00397 crossref_primary_10_1002_anie_200800169 crossref_primary_10_1134_S1995078012030172 crossref_primary_10_3390_ijms140815479 crossref_primary_10_1186_1477_3155_10_45 crossref_primary_10_1016_j_cbpa_2009_11_001 crossref_primary_10_1038_s41563_019_0378_4 crossref_primary_10_1002_anie_201005684 crossref_primary_10_1039_C6CS00271D crossref_primary_10_1021_acsnano_5b01594 crossref_primary_10_1021_ac5004823 crossref_primary_10_1039_c3pp50203a crossref_primary_10_1016_j_ijbiomac_2007_09_002 crossref_primary_10_1002_smll_200901459 crossref_primary_10_1002_ardp_200800031 crossref_primary_10_1007_s00216_010_4010_3 crossref_primary_10_1039_D3CC01355C crossref_primary_10_1038_nchem_871 crossref_primary_10_1039_D0QM00617C crossref_primary_10_1002_smll_202410947 crossref_primary_10_1021_acs_analchem_5b03581 crossref_primary_10_1038_nbt0306_326 crossref_primary_10_1021_am302030a crossref_primary_10_3390_s17051010 crossref_primary_10_1007_s00216_010_3837_y crossref_primary_10_1021_acsnano_5b05966 crossref_primary_10_1109_JSTQE_2011_2164900 crossref_primary_10_1002_mrd_22831 crossref_primary_10_1039_D0MA00273A crossref_primary_10_1002_wnan_1567 crossref_primary_10_1021_ac801562f crossref_primary_10_1088_0957_4484_21_28_285102 crossref_primary_10_1134_S1068162018050114 crossref_primary_10_1016_j_bbrc_2009_03_055 crossref_primary_10_1016_j_ejpb_2007_06_009 crossref_primary_10_3402_nano_v1i0_5161 crossref_primary_10_1007_s11671_007_9061_9 crossref_primary_10_1021_nn202799d crossref_primary_10_1038_s41563_023_01659_1 crossref_primary_10_1021_ja3016582 crossref_primary_10_1364_AOP_8_000001 crossref_primary_10_1002_wnan_78 crossref_primary_10_1016_j_jlumin_2018_09_047 crossref_primary_10_1021_nl801488u crossref_primary_10_1016_j_nano_2006_11_008 crossref_primary_10_1021_acsmaterialslett_3c00978 crossref_primary_10_1007_s10529_011_0641_5 crossref_primary_10_1002_adma_201603794 crossref_primary_10_1038_s41467_019_10119_x crossref_primary_10_1016_j_biomaterials_2011_09_032 crossref_primary_10_1002_smll_200902408 crossref_primary_10_1016_j_biomaterials_2013_07_087 crossref_primary_10_1002_smll_200902409 crossref_primary_10_1016_j_ccr_2013_08_030 crossref_primary_10_1088_0268_1242_23_7_075045 crossref_primary_10_1016_j_nantod_2012_10_007 crossref_primary_10_1039_c3ra43729a crossref_primary_10_1021_acs_jafc_7b02870 crossref_primary_10_1039_D2RA00026A crossref_primary_10_1002_wnan_85 crossref_primary_10_3390_s20102909 crossref_primary_10_1016_j_bbrc_2008_07_004 crossref_primary_10_1016_j_jlumin_2010_01_013 crossref_primary_10_1021_cr5007057 crossref_primary_10_1016_j_bbrc_2006_03_225 crossref_primary_10_1088_0957_4484_21_40_405101 crossref_primary_10_2967_jnumed_111_092965 crossref_primary_10_1021_jp506200a crossref_primary_10_1016_j_commatsci_2010_10_039 crossref_primary_10_1016_j_pep_2013_08_004 crossref_primary_10_1021_bc800421f crossref_primary_10_1038_nrn1905 crossref_primary_10_1016_j_cej_2021_131456 crossref_primary_10_3390_molecules17044047 crossref_primary_10_1038_s41565_024_01809_9 crossref_primary_10_1091_mbc_e16_06_0413 crossref_primary_10_1109_JSTQE_2012_2184793 crossref_primary_10_1002_ange_200601196 crossref_primary_10_1021_acs_analchem_9b00637 crossref_primary_10_1002_ange_200601197 crossref_primary_10_17352_gjbbs_000006 crossref_primary_10_1586_erm_11_86 crossref_primary_10_1021_ac301461s crossref_primary_10_1002_wnan_14 crossref_primary_10_1016_j_ymeth_2009_03_013 crossref_primary_10_1002_chem_200800278 crossref_primary_10_1039_C6NR09716B crossref_primary_10_1016_j_bios_2012_09_025 crossref_primary_10_1016_j_chempr_2017_10_002 crossref_primary_10_1088_0957_4484_21_42_425501 crossref_primary_10_1002_wnan_1515 crossref_primary_10_1002_anie_201900594 crossref_primary_10_1039_D2CS00799A crossref_primary_10_1038_s41377_022_00729_4 crossref_primary_10_1177_030089160809400219 crossref_primary_10_1002_jemt_20928 crossref_primary_10_1016_j_addr_2008_08_004 crossref_primary_10_1073_pnas_0908594106 crossref_primary_10_1016_j_aca_2010_11_043 crossref_primary_10_1155_2007_79169 crossref_primary_10_1002_ange_201004996 crossref_primary_10_1586_erm_13_17 crossref_primary_10_1039_C7CC07752A crossref_primary_10_1021_ja104299t crossref_primary_10_1039_C6CS00296J crossref_primary_10_1016_j_biomaterials_2017_12_002 crossref_primary_10_1088_0957_4484_20_18_185103 crossref_primary_10_1002_adhm_201800497 crossref_primary_10_1039_C4CS00014E crossref_primary_10_1016_j_drudis_2016_03_004 crossref_primary_10_1016_j_jlumin_2008_04_007 crossref_primary_10_1016_j_nano_2013_10_007 crossref_primary_10_1002_adom_201700181 crossref_primary_10_1039_C6RA22433D crossref_primary_10_1002_ange_200903053 crossref_primary_10_1038_nmat3819 crossref_primary_10_1177_096368970901805_615 crossref_primary_10_1016_j_copbio_2007_01_003 crossref_primary_10_1016_j_bios_2011_08_043 crossref_primary_10_1016_j_saa_2016_04_038 crossref_primary_10_1021_nn401911k crossref_primary_10_1007_s00216_009_3033_0 crossref_primary_10_3390_molecules24030537 crossref_primary_10_1016_j_bios_2015_05_018 crossref_primary_10_1039_c3nr34091k crossref_primary_10_1007_BF03256264 crossref_primary_10_1002_cbic_202400450 crossref_primary_10_1038_nnano_2009_326 crossref_primary_10_1038_s41551_016_0010 crossref_primary_10_1002_jat_4180 crossref_primary_10_1038_nprot_2007_478 crossref_primary_10_1016_j_nic_2006_08_002 crossref_primary_10_1517_17425240902889751 crossref_primary_10_1186_s12951_015_0097_1 crossref_primary_10_1002_anie_200903053 crossref_primary_10_1021_cr300143v crossref_primary_10_1039_b915139g crossref_primary_10_1039_c3an01374j crossref_primary_10_3389_fbioe_2024_1389071 crossref_primary_10_1007_s11095_012_0826_1 crossref_primary_10_1016_j_ab_2015_11_028 crossref_primary_10_1021_acs_chemrestox_9b00526 crossref_primary_10_1002_anie_200906399 crossref_primary_10_1039_C5NR08465B crossref_primary_10_1063_1_4941565 crossref_primary_10_1016_j_cbpa_2009_09_029 crossref_primary_10_1016_j_matpr_2017_09_234 crossref_primary_10_1039_C2CC36870F crossref_primary_10_1002_wnan_1705 crossref_primary_10_1016_j_biomaterials_2010_01_134 crossref_primary_10_1021_ic4017883 crossref_primary_10_1016_j_nantod_2011_02_007 crossref_primary_10_1002_anie_201408593 crossref_primary_10_1002_advs_202001476 crossref_primary_10_1007_s11172_018_2114_7 crossref_primary_10_1038_nrc2229 crossref_primary_10_1073_pnas_0702427104 crossref_primary_10_1002_anie_201004996 crossref_primary_10_1364_OME_6_001384 crossref_primary_10_1021_ja402490j crossref_primary_10_1021_nl1036098 crossref_primary_10_1038_srep27993 crossref_primary_10_1016_j_trac_2012_07_014 crossref_primary_10_1038_nprot_2011_381 crossref_primary_10_1016_j_critrevonc_2012_09_004 crossref_primary_10_1039_C3MD00288H crossref_primary_10_3390_molecules23081870 crossref_primary_10_1038_s41467_020_18051_1 crossref_primary_10_1038_srep36588 crossref_primary_10_1039_C4CS00532E crossref_primary_10_1039_c3nr01842c crossref_primary_10_1117_1_2437744 crossref_primary_10_3390_ma17246162 crossref_primary_10_1039_c1cs15035a crossref_primary_10_1016_j_molmed_2020_02_003 crossref_primary_10_1016_j_trac_2010_11_010 crossref_primary_10_1021_acsnano_2c06667 crossref_primary_10_1016_j_actbio_2018_05_004 crossref_primary_10_1016_j_smaim_2021_11_002 crossref_primary_10_1371_journal_pone_0000974 crossref_primary_10_1002_cnma_201600258 crossref_primary_10_1039_C6RA15764E crossref_primary_10_1039_C4AN00294F crossref_primary_10_1039_c1cc11431j crossref_primary_10_1002_chem_200801653 crossref_primary_10_1021_la803542v crossref_primary_10_1007_s11426_016_0022_y crossref_primary_10_1002_smll_201403700 crossref_primary_10_1021_jacs_4c14565 crossref_primary_10_1002_adhm_202302089 crossref_primary_10_1021_jacs_1c07711 crossref_primary_10_1364_OE_18_006477 crossref_primary_10_1016_j_colsurfb_2025_114631 crossref_primary_10_2217_17435889_1_2_209 crossref_primary_10_1016_j_ejca_2012_06_001 crossref_primary_10_1016_j_ab_2006_06_006 crossref_primary_10_1021_acs_est_3c01949 crossref_primary_10_1039_c2sc20519j crossref_primary_10_1002_adma_201606665 crossref_primary_10_1073_pnas_0710575105 crossref_primary_10_3389_fchem_2014_00048 crossref_primary_10_1002_anie_200601197 crossref_primary_10_1002_anie_200601196 crossref_primary_10_1039_b900693a crossref_primary_10_1016_j_ejpb_2023_11_008 crossref_primary_10_1039_c3cp51509e crossref_primary_10_1016_j_nantod_2015_09_004 crossref_primary_10_1007_s13139_016_0435_8 crossref_primary_10_1016_j_addr_2020_07_017 crossref_primary_10_1002_smll_201201492 crossref_primary_10_1002_anie_201502736 crossref_primary_10_1039_D2CC06178C crossref_primary_10_1007_s00216_016_9434_y crossref_primary_10_1016_j_talanta_2011_04_077 crossref_primary_10_1146_annurev_anchem_061010_113855 crossref_primary_10_1016_j_ejphar_2022_175350 crossref_primary_10_1021_ja803920b crossref_primary_10_1016_j_jconrel_2016_01_004 crossref_primary_10_1021_nl102172j crossref_primary_10_1002_adbi_201800108 crossref_primary_10_1021_ja0731017 crossref_primary_10_3389_fchem_2014_00063 crossref_primary_10_1021_jacs_6b05078 crossref_primary_10_1021_acsanm_4c01456 crossref_primary_10_2967_jnumed_109_069880 crossref_primary_10_1016_j_optmat_2012_02_049 crossref_primary_10_1039_c3an01239e crossref_primary_10_1039_D2SC01770A crossref_primary_10_1007_s00604_016_2057_3 crossref_primary_10_1002_ange_201005684 crossref_primary_10_1039_c2sc22035k crossref_primary_10_1016_j_biomaterials_2014_08_038 crossref_primary_10_1096_fj_201900816RR crossref_primary_10_1002_ange_201405849 crossref_primary_10_1002_anie_200503873 crossref_primary_10_1016_j_colsurfb_2014_06_002 crossref_primary_10_1039_C6CC02764D crossref_primary_10_1002_smll_200900017 crossref_primary_10_2217_17435889_2_3_307 crossref_primary_10_1016_j_mattod_2017_09_003 crossref_primary_10_1038_nprot_2006_162 crossref_primary_10_1016_j_ijrobp_2008_06_1916 crossref_primary_10_1016_j_electacta_2011_05_017 crossref_primary_10_1115_1_4006923 crossref_primary_10_1039_C0NR00647E crossref_primary_10_1016_j_jlumin_2018_11_013 crossref_primary_10_1080_10408430902831987 crossref_primary_10_1002_ange_202007520 crossref_primary_10_1186_1743_8977_10_37 crossref_primary_10_1021_jp304107b crossref_primary_10_1002_biot_200700222 crossref_primary_10_1152_physrev_00049_2010 crossref_primary_10_1002_bio_2629 crossref_primary_10_1038_ncomms8560 crossref_primary_10_1039_C8RA01036F crossref_primary_10_1039_C9BM01629E crossref_primary_10_1016_j_ejpb_2007_05_013 crossref_primary_10_1021_acs_chemmater_0c00547 crossref_primary_10_1039_C8CS00278A crossref_primary_10_1016_j_nano_2016_02_014 |
| Cites_doi | 10.1038/nbt920 10.1021/ja045676z 10.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.0.CO;2-S 10.1162/153535004773861688 10.1126/science.1077194 10.1038/nbt764 10.1038/nmat961 10.1146/annurev.cellbio.14.1.197 10.1073/pnas.012611099 10.1021/ja031691c 10.1146/annurev.bioeng.4.111901.093336 10.1038/nm0298-245 10.1021/jp025698c 10.1021/jp971091y 10.1016/j.tcb.2004.07.012 10.1073/pnas.0403343101 10.1126/science.281.5385.2013 10.1126/science.1104274 10.1096/fj.05-4628fje 10.1038/nmat1390 10.1101/gad.1047403 10.1021/nl015519n 10.1126/science.281.5385.2016 10.1038/nbt994 10.1111/j.1751-1097.1978.tb07621.x |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2006 2006 INIST-CNRS COPYRIGHT 2006 Nature Publishing Group Copyright Nature Publishing Group Mar 2006 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2006 – notice: 2006 INIST-CNRS – notice: COPYRIGHT 2006 Nature Publishing Group – notice: Copyright Nature Publishing Group Mar 2006 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QO 7QP 7QR 7T7 7TK 7TM 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH HCIFZ K9. L6V LK8 M0S M1P M2O M2P M7P M7S MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS Q9U RC3 7X8 |
| DOI | 10.1038/nbt1188 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Biotechnology Research Abstracts Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) Materials Science & Engineering Collection (ProQuest) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection (subscription) ProQuest Central Technology Collection (ProQuest) Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Engineering Collection ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Research Library (Proquest) Science Database Biological Science Database (Proquest) Engineering Database (Proquest) Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection (ProQuest) ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Engineering Database ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Research Library ProQuest Central Basic ProQuest Science Journals ProQuest SciTech Collection ProQuest Medical Library Materials Science & Engineering Collection ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Research Library Prep MEDLINE Engineering Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Engineering Agriculture Biology |
| EISSN | 1546-1696 |
| EndPage | 343 |
| ExternalDocumentID | 1012321861 A191182650 16501578 17585399 10_1038_nbt1188 |
| Genre | Comparative Study Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: 5R01CA82214-7 – fundername: NCI NIH HHS grantid: P50 CA114747 – fundername: NCI NIH HHS grantid: R24CA92862 |
| GroupedDBID | --- -~X .55 .GJ 0R~ 123 29M 2FS 2XV 36B 39C 3V. 4.4 4R4 53G 5BI 5RE 70F 7X7 88A 88E 88I 8AO 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 A8Z AAEEF AAHBH AAIKC AAMNW AARCD AAYOK AAYZH ABAWZ ABDBF ABDPE ABEFU ABJCF ABJNI ABLJU ABOCM ABUWG ACBTR ACBWK ACGFO ACGFS ACGOD ACIWK ACMJI ACPRK ADBBV ADFRT AENEX AEUYN AFFNX AFKRA AFRAH AFSHS AGAYW AGHTU AHBCP AHMBA AHSBF ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ASPBG AVWKF AXYYD AZFZN AZQEC BAAKF BBNVY BENPR BGLVJ BHPHI BKKNO BPHCQ BVXVI C0K CCPQU D1J DB5 DU5 DWQXO EAD EAP EAS EBS EE. EJD EMB EMK ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAG IAO IEA IEP IH2 IHR INH INR IOV ISR ITC KOO L6V LK8 M0L M1P M2O M2P M7P M7S N95 NEJ O9- P2P PKN PQQKQ PROAC PSQYO PTHSS Q2X QF4 QM4 QN7 QO4 RNS RNT RNTTT RXW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TN5 TSG U5U UKHRP X7M XI7 XOL Y6R YZZ ZHY ~KM AAYXX ACMFV ACSTC AFANA ALPWD ATHPR CITATION PHGZM PHGZT 5M7 5S5 ABFSG ACUHS AEZWR AFBBN AFHIU AHOSX AHWEU AIBTJ AIXLP ARMCB BKOMP EBC EMOBN FA8 IQODW LGEZI LOTEE ML0 MVM NADUK NFIDA NNMJJ NXXTH ODYON PJZUB PPXIY PQGLB RVV SHXYY SIXXV TUS ZGI ZXP AAZLF CGR CUY CVF ECM EIF NPM PMFND 7QO 7QP 7QR 7T7 7TK 7TM 7XB 8FD 8FK C1K FR3 K9. MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7X8 |
| ID | FETCH-LOGICAL-c573t-34c654ea8f2d0b8e7f3825b36e05e0465a68cc66f9e8017f1b9eb5e9385001773 |
| IEDL.DBID | 7X7 |
| ISSN | 1087-0156 |
| IngestDate | Fri Jul 11 10:41:14 EDT 2025 Mon Jul 21 09:40:22 EDT 2025 Sun Aug 17 23:49:57 EDT 2025 Tue Jun 10 21:29:47 EDT 2025 Fri Jun 27 03:48:26 EDT 2025 Fri Jun 27 05:06:32 EDT 2025 Wed Feb 19 01:44:22 EST 2025 Mon Jul 21 09:14:21 EDT 2025 Tue Jul 01 04:29:27 EDT 2025 Thu Apr 24 23:06:52 EDT 2025 Fri Feb 21 02:36:42 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | Bioluminescence Quantum dot Semiconductor materials Enzyme Luciferase Fluorescence Imagery In vivo Tissue Resonant energy transfer Animal Oxidoreductases Conjugated compound |
| Language | English |
| License | http://www.springer.com/tdm CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c573t-34c654ea8f2d0b8e7f3825b36e05e0465a68cc66f9e8017f1b9eb5e9385001773 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 content type line 23 |
| PMID | 16501578 |
| PQID | 222307756 |
| PQPubID | 47191 |
| PageCount | 5 |
| ParticipantIDs | proquest_miscellaneous_67727990 proquest_miscellaneous_19427939 proquest_journals_222307756 gale_infotracacademiconefile_A191182650 gale_incontextgauss_ISR_A191182650 gale_incontextgauss_IOV_A191182650 pubmed_primary_16501578 pascalfrancis_primary_17585399 crossref_primary_10_1038_nbt1188 crossref_citationtrail_10_1038_nbt1188 springer_journals_10_1038_nbt1188 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2006-03-01 |
| PublicationDateYYYYMMDD | 2006-03-01 |
| PublicationDate_xml | – month: 03 year: 2006 text: 2006-03-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: New York, NY – name: United States |
| PublicationSubtitle | The Science and Business of Biotechnology |
| PublicationTitle | Nature biotechnology |
| PublicationTitleAbbrev | Nat Biotechnol |
| PublicationTitleAlternate | Nat Biotechnol |
| PublicationYear | 2006 |
| Publisher | Nature Publishing Group US Nature Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature – name: Nature Publishing Group |
| References | CH Contag (BFnbt1188_CR24) 2002; 4 TF Massoud (BFnbt1188_CR23) 2003; 17 PR Contag (BFnbt1188_CR25) 1998; 4 WCW Chan (BFnbt1188_CR9) 1998; 281 BO Dabbousi (BFnbt1188_CR6) 1997; 101 IL Medintz (BFnbt1188_CR20) 2003; 2 X Gao (BFnbt1188_CR3) 2004; 22 S Bhaumik (BFnbt1188_CR26) 2002; 99 IL Medintz (BFnbt1188_CR5) 2005; 4 T Troy (BFnbt1188_CR15) 2004; 3 IL Medintz (BFnbt1188_CR21) 2004; 101 WW Ward (BFnbt1188_CR17) 1978; 27 JK Jaiswal (BFnbt1188_CR4) 2004; 14 F Pinaud (BFnbt1188_CR11) 2004; 126 M Bruchez (BFnbt1188_CR8) 1998; 281 CA Leatherdale (BFnbt1188_CR7) 2002; 106 CM Niemeyer (BFnbt1188_CR10) 2001; 40 X Wu (BFnbt1188_CR13) 2003; 21 X Michalet (BFnbt1188_CR1) 2005; 307 AR Clapp (BFnbt1188_CR22) 2005; 127 S Kim (BFnbt1188_CR2) 2004; 22 B Dubertret (BFnbt1188_CR14) 2002; 298 A De (BFnbt1188_CR19) 2005; 19 BFnbt1188_CR16 NN Mamedova (BFnbt1188_CR12) 2001; 1 T Wilson (BFnbt1188_CR18) 1998; 14 16525407 - Nat Biotechnol. 2006 Mar;24(3):326-8 |
| References_xml | – volume: 22 start-page: 93 year: 2004 ident: BFnbt1188_CR2 publication-title: Nat. Biotechnol. doi: 10.1038/nbt920 – volume: 127 start-page: 1242 year: 2005 ident: BFnbt1188_CR22 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja045676z – volume: 40 start-page: 4128 year: 2001 ident: BFnbt1188_CR10 publication-title: Angew. Chem. Int. Edn. Engl. doi: 10.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.0.CO;2-S – volume: 3 start-page: 9 year: 2004 ident: BFnbt1188_CR15 publication-title: Mol. Imaging doi: 10.1162/153535004773861688 – volume: 298 start-page: 1759 year: 2002 ident: BFnbt1188_CR14 publication-title: Science doi: 10.1126/science.1077194 – volume: 21 start-page: 41 year: 2003 ident: BFnbt1188_CR13 publication-title: Nat. Biotechnol. doi: 10.1038/nbt764 – volume: 2 start-page: 630 year: 2003 ident: BFnbt1188_CR20 publication-title: Nat. Mater. doi: 10.1038/nmat961 – volume: 14 start-page: 197 year: 1998 ident: BFnbt1188_CR18 publication-title: Annu. Rev. Cell Dev. Biol. doi: 10.1146/annurev.cellbio.14.1.197 – volume: 99 start-page: 377 year: 2002 ident: BFnbt1188_CR26 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.012611099 – volume: 126 start-page: 6115 year: 2004 ident: BFnbt1188_CR11 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja031691c – volume: 4 start-page: 235 year: 2002 ident: BFnbt1188_CR24 publication-title: Annu. Rev. Biomed. Eng. doi: 10.1146/annurev.bioeng.4.111901.093336 – volume: 4 start-page: 245 year: 1998 ident: BFnbt1188_CR25 publication-title: Nat. Med. doi: 10.1038/nm0298-245 – volume: 106 start-page: 7619 year: 2002 ident: BFnbt1188_CR7 publication-title: J. Phys. Chem. B doi: 10.1021/jp025698c – volume: 101 start-page: 9463 year: 1997 ident: BFnbt1188_CR6 publication-title: J. Phys. Chem. B doi: 10.1021/jp971091y – volume: 14 start-page: 497 year: 2004 ident: BFnbt1188_CR4 publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2004.07.012 – volume: 101 start-page: 9612 year: 2004 ident: BFnbt1188_CR21 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0403343101 – ident: BFnbt1188_CR16 – volume: 281 start-page: 2013 year: 1998 ident: BFnbt1188_CR8 publication-title: Science doi: 10.1126/science.281.5385.2013 – volume: 307 start-page: 538 year: 2005 ident: BFnbt1188_CR1 publication-title: Science doi: 10.1126/science.1104274 – volume: 19 start-page: 2017 year: 2005 ident: BFnbt1188_CR19 publication-title: FASEB J. doi: 10.1096/fj.05-4628fje – volume: 4 start-page: 435 year: 2005 ident: BFnbt1188_CR5 publication-title: Nat. Mater. doi: 10.1038/nmat1390 – volume: 17 start-page: 545 year: 2003 ident: BFnbt1188_CR23 publication-title: Genes Dev. doi: 10.1101/gad.1047403 – volume: 1 start-page: 281 year: 2001 ident: BFnbt1188_CR12 publication-title: Nano Lett. doi: 10.1021/nl015519n – volume: 281 start-page: 2016 year: 1998 ident: BFnbt1188_CR9 publication-title: Science doi: 10.1126/science.281.5385.2016 – volume: 22 start-page: 969 year: 2004 ident: BFnbt1188_CR3 publication-title: Nat. Biotechnol. doi: 10.1038/nbt994 – volume: 27 start-page: 389 year: 1978 ident: BFnbt1188_CR17 publication-title: Photochem. Photobiol. doi: 10.1111/j.1751-1097.1978.tb07621.x – reference: 16525407 - Nat Biotechnol. 2006 Mar;24(3):326-8 |
| SSID | ssj0006466 |
| Score | 2.4420867 |
| Snippet | Fluorescent semiconductor quantum dots hold great potential for molecular imaging
in vivo
1
,
2
,
3
,
4
,
5
. However, the utility of existing quantum dots for... Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo. However, the utility of existing quantum dots for in vivo imaging is... Fluorescent semiconductor quantum dots hold great potential for molecular imaging in vivo super(1, ) super(2, ) super(3, ) super(4, ) super(5). However, the... |
| SourceID | proquest gale pubmed pascalfrancis crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 339 |
| SubjectTerms | Agriculture Animals Bioinformatics Biological and medical sciences Bioluminescence Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Diagnostic Imaging Diverse techniques Energy Transfer Enzymes Fluorescence Fundamental and applied biological sciences. Psychology letter Life Sciences Luciferases - genetics Luciferases - metabolism Luminescent Measurements - methods Mice Mice, Nude Microscopy, Fluorescence Molecular and cellular biology Quantum Dots Renilla reniformis Resonance Scientific imaging Semiconductors Sensitivity and Specificity |
| Title | Self-illuminating quantum dot conjugates for in vivo imaging |
| URI | https://link.springer.com/article/10.1038/nbt1188 https://www.ncbi.nlm.nih.gov/pubmed/16501578 https://www.proquest.com/docview/222307756 https://www.proquest.com/docview/19427939 https://www.proquest.com/docview/67727990 |
| Volume | 24 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9RAEB-0RVFE9NQaq-cqok-hl2x2swFBqvSsQqu0ttxb2Gw2JaVNruZS8L93Jtm786z1JS8ZyGZ2vn47szMAb_LAFBw1wc8VahPGt9JPQq19U1guZc6TwNDd4b19uXsUfZ2IiavNaVxZ5dwmdoY6rw2dkW-RH6N2bfLD9MKnoVGUXHUTNG7COnUuo4queLLAW-hsu1RlMFJUXSlkf2eWOoJvVdkMI2u14oycSb431Q2yp-jnWvwr8LySNO180fgB3HdBJNvud_0h3LDVAG71YyV_DeDuH00GB3B7z6XPH8H7Q3tW-CUNNy7pFLA6YRctsrY9ZwhOGULj05aO1RqGoSwrK3ZZXtasPO8mGT2Go_HOj0-7vhuf4BsR85nPIyNFZLUqwnyUKRsXHOFgxqUdCYuwWGipjJGySCy6qbgIssRmwiZcCfJdMX8Ca1Vd2afAlA6tCaTNVZhEQlhlgxCxmk6iMFNGhh68nfMxNa63OI24OEu7HDdXqWO4B2xBOO3baVwleU0bkVJzioqqX0502zTpl2_H6TaCS8JDYnQd0eHBCtE7R1TUuBqj3Y0D_CdqerVCOVzZ9eXaCE5hDOfB5lwMUqfkTboQSQ9eLt6idlLKRVe2bps0QA6hBUyup5AIb2IMCTzY6KVr-W1cWIAG1YNXc3Fbfvsvpj377_o24U5_ckSlc89hbfaztS8wlpplw05j8KnGn4ew_nFn__vBbx2eHYs |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9QwEB6VIi4hBMsVCq1BHE9RN3HsOBIIVcCyS7tFoi3qW0gcpwpqky3ZFPVH8R-ZybHLUspbnzNKnLk8n2c8A_A8cXTK0RLsRKE1YXwr7cCNIlunhkuZ8MDRdHd4vC2He96nfbG_BL-6uzBUVtn5xNpRJ4WmM_J12seoXZt8Ozm2aWgUJVe7CRqNVmya05-I2Mo3o_co3heuO_iw-25ot0MFbC18PrW5p6XwTKRSN-nHyvgpR5AUc2n6wiBYFJFUWkuZBgadt586cWBiYQKuBHl0n-N7L8Flj_OADEoNPs4cv2xSo05fUTWnkM0dXepAvp7HU4zk1cLm124BNydRieJImzka_wp0zyRp671vcBtutUEr22i07A4smbwHV5oxlqc9uPFHU8MeXB236fq78HrHHKZ2RsOUMzp1zA_YcYWirI4YgmGGUPx7Rcd4JcPQmWU5O8lOCpYd1ZOT7sHehXD2PiznRW4eAlORa7QjTaLcwBPCKOO4iA2jwHNjpaVrwcuOj6Fue5nTSI3DsM6pcxW2DLeAzQgnTfuOsyTPSBAhNcPIqdrmIKrKMhx9_hpuIJgl_CX65xHtfFkgetUSpQWuRkftDQf8J2qytUC5uiD1-doIvmHMaMFKpwZh61TKcGYCFqzNnqI3oBRPlJuiKkMHOYQeNzifQiKc8jEEseBBo13zb-PCHHTgFjzt1G3-7b-Y9ui_61uDa8Pd8Va4NdreXIHrzakVle09huXpj8o8wThuGq_W1sPg20Wb6281ZlbD |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3rT9RAEJ8gRqIxRs9XRWE1Pj41d-12t9tEY4h44UTQCJj7VtvtltRAe9grhj_N_86ZPu48Eb_xuZN2O-_fzu4MwPPE0SlHS7AThdaE-a20AzeKbJ0aLmXCA0fT3eGdXbl14H0Yi_ES_OruwtCxys4n1o46KTTtkfcpjlG7NtlP21MRnzeHbycnNg2QokJrN02j0ZBtc_YT0Vv5ZrSJon7husP3---27HbAgK2Fz6c297QUnolU6iaDWBk_5QiYYi7NQBgEjiKSSmsp08CgI_dTJw5MLEzAlSDv7nN87xW46nPhkIn54xnWw0Bfl0mdgaKTnUI293WpG3k_j6eY1auFQNiGg5uTqETRpM1MjX8lvecKtnUcHN6GW20CyzYajbsDSybvwbVmpOVZD2780eCwBys7ben-LrzeM0epndFg5Yx2IPNDdlKhWKtjhsCYISz_XtGWXskwjWZZzk6z04Jlx_UUpXtwcCmcvQ_LeZGbh8BU5BrtSJMoN_CEMMo4LuLEKPDcWGnpWvCy42Oo277mNF7jKKzr61yFLcMtYDPCSdPK4zzJMxJESI0xctKxw6gqy3D06Wu4gcCWsJgYXES092WB6FVLlBa4Gh21tx3wn6jh1gLl2oLU52sjKIf5owWrnRqErYMpw5k5WLA-e4qegco9UW6Kqgwd5BB63-BiConQysd0xIIHjXbNv40Lc9CZW_C0U7f5t_9i2qP_rm8dVtBQw4-j3e1VuN5sYNEJvsewPP1RmSeY0k3jtdp4GHy7bGv9DTzMWvA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Self-illuminating+quantum+dot+conjugates+for+in+vivo+imaging&rft.jtitle=Nature+biotechnology&rft.au=So%2C+Min-Kyung&rft.au=Xu%2C+Chenjie&rft.au=Loening%2C+Andreas+M&rft.au=Gambhir%2C+Sanjiv+S&rft.date=2006-03-01&rft.pub=Nature+Publishing+Group+US&rft.issn=1087-0156&rft.eissn=1546-1696&rft.volume=24&rft.issue=3&rft.spage=339&rft.epage=343&rft_id=info:doi/10.1038%2Fnbt1188&rft.externalDocID=10_1038_nbt1188 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1087-0156&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1087-0156&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1087-0156&client=summon |