Targeting insulin inhibition as a metabolic therapy in advanced cancer: A pilot safety and feasibility dietary trial in 10 patients

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 28; no. 10; pp. 1028 - 1035
• Main Authors: Fine, Eugene J., Segal-Isaacson, C.J., Feinman, Richard D., Herszkopf, Silvia, Romano, Maria C., Tomuta, Norica, Bontempo, Amanda F., Negassa, Abdissa, Sparano, Joseph A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2012; Elsevier; Elsevier Limited
• Subjects: adverse effects; Aged; Biological and medical sciences; blood; body mass index; Body weight; Calorie restriction; Cancer; Cancer metabolism; Cancer therapies; Carbohydrate restriction; cytotoxicity; diabetes; Diet; diet study techniques; diet therapy; Diet, Carbohydrate-Restricted; Diet, Carbohydrate-Restricted - adverse effects; dietary carbohydrate; Dietary Carbohydrates; Dietary Carbohydrates - metabolism; Dietary Carbohydrates - pharmacology; dietary restriction; Dietary restrictions; Disease Progression; electrolytes; Energy Intake; etiology; Feasibility Studies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Glycolysis; Growth factors; Humans; Insulin; Insulin - blood; Insulin - metabolism; Insulin inhibition; Insulin Secretion; Insulin-like growth factors; Ketosis; Ketosis - etiology; Kinases; Male; metabolism; Middle Aged; Neoplasms; Neoplasms - diet therapy; Neoplasms - metabolism; patients; pharmacology; Pilot Projects; positron-emission tomography; Proteins; remission; secretion; therapeutics; Therapy; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Warburg effect; Weight Loss; Insulin inhibition; Therapy; Cancer metabolism; Diet; Calorie restriction; Ketosis; Carbohydrate restriction; Warburg effect; Calorie; Human; Pancreatic hormone; Toxicity; Malignant tumor; Metabolism; Insulin; Feeding; Metabolic disorder; Vertebrata; Mammalia; Feasibility; Carbohydrate; Inhibition; Safety; Cancer

Most aggressive cancers demonstrate a positive positron emission tomographic (PET) result using 18F-2-fluoro-2-deoxyglucose (FDG), reflecting a glycolytic phenotype. Inhibiting insulin secretion provides a method, consistent with published mechanisms, for limiting cancer growth. Eligible patients wi...