Irritant-evoked activation and calcium modulation of the TRPA1 receptor

• Published in: Nature (London) Vol. 585; no. 7823; pp. 141 - 145
• Main Authors: Zhao, Jianhua, Lin King, John V., Paulsen, Candice E., Cheng, Yifan, Julius, David
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.09.2020; Nature Publishing Group
• Subjects: 101/28; 631/443/376; 631/535/1258/1259; 82; 82/16; 82/83; 9/74; Activation; Amino Acid Sequence; Analgesics; Calcium; Calcium - metabolism; Calcium - pharmacology; Calcium permeability; Cysteine; Cysteine - metabolism; Desensitization; Electric Conductivity; Electrophysiology; Fibers; Humanities and Social Sciences; Humans; Inflammation; Iodoacetamide - pharmacology; Ion Channel Gating - drug effects; Ion channels; Ligands; Metabotropic receptors; Models, Molecular; multidisciplinary; Mutation; Oximes - pharmacology; Pain; Potentiation; Receptors; Restrictions; Science; Science (multidisciplinary); Second messengers; Selectivity; Sensory neurons; Toxicants; Transient receptor potential proteins; TRPA1 Cation Channel - chemistry; TRPA1 Cation Channel - genetics; TRPA1 Cation Channel - metabolism

The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including small volatile environmental toxicants and endogenous algogenic lipids 1 . TRPA1 is also a ‘re...