Action of aromatase inhibitor for treatment of uterine leiomyoma in perimenopausal patients

• Published in: Fertility and sterility Vol. 91; no. 1; pp. 240 - 243
• Main Authors: Hilário, Sandro G., M.D, Bozzini, Nilo, Ph.D, Borsari, Rodrigo, M.D, Baracat, Edmund C., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2009; Elsevier
• Subjects: Adult; anastrozol; Antineoplastic Agents, Hormonal - therapeutic use; Aromatase Inhibitors - therapeutic use; Biological and medical sciences; Estradiol - blood; Female; Female genital diseases; Follicle Stimulating Hormone - blood; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; Leiomyoma - drug therapy; leiomyoma therapy; Medical sciences; Menstruation - drug effects; Menstruation - physiology; Middle Aged; Nitriles - therapeutic use; Obstetrics and Gynecology; Perimenopause; premenopause; Triazoles - therapeutic use; Tumors; Uterine Neoplasms - blood; Uterine Neoplasms - drug therapy; leiomyoma therapy; premenopause; anastrozol; Aromatase inhibitors/therapeutic use; Human; Aromatase inhibitor; Premenopause; Gynecology; Obstetrics; Female genital diseases; Treatment; Uterine diseases; Uterine leiomyoma; Perimenopause; Benign neoplasm
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2007.11.006

Objective To assess the effect of the aromatase inhibitor on patients with leiomyoma in the reproductive stage regarding reduction of uterine volume and control of symptoms. Design Clinical study. Setting Academic clinical practice. Patient(s) Twenty patients, over 35 years of age, with symptomatic uterine leiomyoma. Intervention(s) Anastrozol, 1 mg/day for 12 weeks. Main Outcome Measure(s) Measurement of uterine volume, assessment of symptoms related to uterine leiomyoma, serum assay of follicle stimulating hormone (FSH), and estradiol. Results Average reduction of uterine volume of 9.32%, attaining up to 32%, and reduction of symptoms of uterine leiomyoma (menstrual volume, duration of menstruation, and dysmenorrhea). No significant change in serum levels of FSH and estradiol during use of the medication were observed. Conclusion(s) Anastrozol proved to be effective in reducing the volume of the uterus–leiomyoma structure, leading to the control of symptoms connected with the disorder without changes in serum FSH and estradiol.