Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells

• Published in: Psychiatry research Vol. 188; no. 2; pp. 224 - 230
• Main Authors: Chen, Yili, Jiang, Tang, Chen, Peisong, Ouyang, Juan, Xu, Guiyun, Zeng, Zhijie, Sun, Yanhong
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 30.07.2011; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Antibodies, Antinuclear - blood; Autoimmune process; Autoimmunity - physiology; Biological and medical sciences; Depression; Depressive Disorder, Major - immunology; Depressive Disorder, Major - pathology; Enzyme-Linked Immunosorbent Assay - methods; Female; Flow Cytometry; Humans; Interleukin-17 - blood; Major depressive disorder; Male; Medical sciences; Middle Aged; Mood disorders; Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; RNA, Messenger - metabolism; Statistics, Nonparametric; Th17 cells; Th17 Cells - immunology; Young Adult; Autoimmune process; Major depressive disorder; Th17 cells; Mood disorder; Autoimmunity; Human; Cytokine; Helper cell; Depression; Cell subpopulation; Interleukin 17

Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of au...