Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells

Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of au...

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Published in	Psychiatry research Vol. 188; no. 2; pp. 224 - 230
Main Authors	Chen, Yili, Jiang, Tang, Chen, Peisong, Ouyang, Juan, Xu, Guiyun, Zeng, Zhijie, Sun, Yanhong
Format	Journal Article
Language	English
Published	Kidlington Elsevier Ireland Ltd 30.07.2011 Elsevier
Subjects	Adult Adult and adolescent clinical studies Antibodies, Antinuclear - blood Autoimmune process Autoimmunity - physiology Biological and medical sciences Depression Depressive Disorder, Major - immunology Depressive Disorder, Major - pathology Enzyme-Linked Immunosorbent Assay - methods Female Flow Cytometry Humans Interleukin-17 - blood Major depressive disorder Male Medical sciences Middle Aged Mood disorders Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RNA, Messenger - metabolism Statistics, Nonparametric Th17 cells Th17 Cells - immunology Young Adult Autoimmune process Major depressive disorder Th17 cells Mood disorder Autoimmunity Human Cytokine Helper cell Depression Cell subpopulation Interleukin 17
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Abstract	Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of autoimmunity. We included 40 patients with MDD and 30 healthy control subjects. An indirect immunofluorescence test was used for the detection of serum antinuclear antibodies (ANA), and revealed that the patient group was positive more frequently than the control group. By flow cytometric analysis, depressed subjects revealed a significant increase in peripheral Th17 cell number, and an obvious decrease in T-reg cell number, showing an imbalance of Th17/Treg ratio compared to healthy controls. We also found a higher level of RORγt (retinoic acid-related orphan receptor-γt, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes by RT-PCR and serum concentration of IL-17 by ELISA in patients. In conclusion, our study showed a potential role of Th17 cells in the autoimmune process in MDD patients, thus contributing to the existing evidence of autoimmune inclination in MDD.
AbstractList	Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of autoimmunity. We included 40 patients with MDD and 30 healthy control subjects. An indirect immunofluorescence test was used for the detection of serum antinuclear antibodies (ANA), and revealed that the patient group was positive more frequently than the control group. By flow cytometric analysis, depressed subjects revealed a significant increase in peripheral Th17 cell number, and an obvious decrease in T-reg cell number, showing an imbalance of Th17/Treg ratio compared to healthy controls. We also found a higher level of RORγt (retinoic acid-related orphan receptor-γt, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes by RT-PCR and serum concentration of IL-17 by ELISA in patients. In conclusion, our study showed a potential role of Th17 cells in the autoimmune process in MDD patients, thus contributing to the existing evidence of autoimmune inclination in MDD. Abstract Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of autoimmunity. We included 40 patients with MDD and 30 healthy control subjects. An indirect immunofluorescence test was used for the detection of serum antinuclear antibodies (ANA), and revealed that the patient group was positive more frequently than the control group. By flow cytometric analysis, depressed subjects revealed a significant increase in peripheral Th17 cell number, and an obvious decrease in T-reg cell number, showing an imbalance of Th17/Treg ratio compared to healthy controls. We also found a higher level of RORγt (retinoic acid-related orphan receptor-γt, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes by RT-PCR and serum concentration of IL-17 by ELISA in patients. In conclusion, our study showed a potential role of Th17 cells in the autoimmune process in MDD patients, thus contributing to the existing evidence of autoimmune inclination in MDD. Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of autoimmunity. We included 40 patients with MDD and 30 healthy control subjects. An indirect immunofluorescence test was used for the detection of serum antinuclear antibodies (ANA), and revealed that the patient group was positive more frequently than the control group. By flow cytometric analysis, depressed subjects revealed a significant increase in peripheral Th17 cell number, and an obvious decrease in T-reg cell number, showing an imbalance of Th17/Treg ratio compared to healthy controls. We also found a higher level of RORγt (retinoic acid-related orphan receptor-γt, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes by RT-PCR and serum concentration of IL-17 by ELISA in patients. In conclusion, our study showed a potential role of Th17 cells in the autoimmune process in MDD patients, thus contributing to the existing evidence of autoimmune inclination in MDD.Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate the mechanism of autoimmune process in MDD from a novel insight of Th17 cells, which have been identified as the significant activators of autoimmunity. We included 40 patients with MDD and 30 healthy control subjects. An indirect immunofluorescence test was used for the detection of serum antinuclear antibodies (ANA), and revealed that the patient group was positive more frequently than the control group. By flow cytometric analysis, depressed subjects revealed a significant increase in peripheral Th17 cell number, and an obvious decrease in T-reg cell number, showing an imbalance of Th17/Treg ratio compared to healthy controls. We also found a higher level of RORγt (retinoic acid-related orphan receptor-γt, the specific transcription factor of Th17 cell) mRNA expression in peripheral blood lymphocytes by RT-PCR and serum concentration of IL-17 by ELISA in patients. In conclusion, our study showed a potential role of Th17 cells in the autoimmune process in MDD patients, thus contributing to the existing evidence of autoimmune inclination in MDD.
Author	Chen, Yili Xu, Guiyun Zeng, Zhijie Sun, Yanhong Chen, Peisong Jiang, Tang Ouyang, Juan
Author_xml	– sequence: 1 givenname: Yili surname: Chen fullname: Chen, Yili organization: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China – sequence: 2 givenname: Tang surname: Jiang fullname: Jiang, Tang email: jiangtangandlily@163.com organization: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China – sequence: 3 givenname: Peisong surname: Chen fullname: Chen, Peisong organization: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China – sequence: 4 givenname: Juan surname: Ouyang fullname: Ouyang, Juan organization: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China – sequence: 5 givenname: Guiyun surname: Xu fullname: Xu, Guiyun organization: Psychiatric Institute of Mental Health Hospital, Guangzhou, Guangdong, China – sequence: 6 givenname: Zhijie surname: Zeng fullname: Zeng, Zhijie organization: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China – sequence: 7 givenname: Yanhong surname: Sun fullname: Sun, Yanhong organization: Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Snippet	Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to investigate... Abstract Evidence indicates that there is an emerging tendency towards autoimmunity occuring in major depressive disorder (MDD). The aim of our study is to...
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SubjectTerms	Adult Adult and adolescent clinical studies Antibodies, Antinuclear - blood Autoimmune process Autoimmunity - physiology Biological and medical sciences Depression Depressive Disorder, Major - immunology Depressive Disorder, Major - pathology Enzyme-Linked Immunosorbent Assay - methods Female Flow Cytometry Humans Interleukin-17 - blood Major depressive disorder Male Medical sciences Middle Aged Mood disorders Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry RNA, Messenger - metabolism Statistics, Nonparametric Th17 cells Th17 Cells - immunology Young Adult
Title	Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells
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