Association between estrogen receptora gene (ESR1) PvuII (T/C) and XbaI (A/G) polymorphisms and premature ovarian failure risk: evidence from a meta-analysis

• Published in: Journal of assisted reproduction and genetics Vol. 32; no. 2; pp. 297 - 304
• Main Authors: He, Meirong, Shu, Jingcheng, Huang, Xing, Tang, Hui
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.02.2015; Springer Nature B.V
• Subjects: Amenorrhea; Asian Continental Ancestry Group - genetics; Asian people; Confidence intervals; Deoxyribonucleases, Type II Site-Specific - genetics; Deoxyribonucleases, Type II Site-Specific - metabolism; DNA-Cytosine Methylases - genetics; DNA-Cytosine Methylases - metabolism; Estrogen Receptor alpha - genetics; Estrogens; Female; Genetic Predisposition to Disease; Genetics; Gynecology; Human Genetics; Humans; Infertility; Medicine; Medicine & Public Health; Meta-analysis; Otolaryngology; Ovaries; Polymorphism; Polymorphism, Single Nucleotide; Primary Ovarian Insufficiency - genetics; Reproductive Medicine; Womens health; Estrogen receptor alpha gene; Premature ovarian failure; Polymorphism; Meta-analysis

Background and aims Genetic factors are important in the pathogenesis of Premature ovarian failure (POF). Notably, estrogen receptor-a ( ESR1 ) has been suggested as a possible candidate gene for POF; however, published studies of ESR1 gene polymorphisms have been hampered by small sample sizes and...