Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement

• Published in: Nature communications Vol. 10; no. 1; pp. 3234 - 11
• Main Authors: Zhou, Bo, Zhang, Ying-Qi, Zhang, Kairui, Yang, Ming-Yang, Chen, Yang-Bo, Li, You, Peng, Qian, Zhu, Shou-Fei, Zhou, Qi-Lin, Ye, Long-Wu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.07.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/131; 639/638/403/933; 639/638/403/934; Acids; Alkenes - chemistry; Alkynes - chemistry; Anticancer properties; Antitumor agents; Atom economy; Biological activity; Breast cancer; Catalysis; Cyclization; Economics; Efficiency; Esophageal cancer; Esophagus; Humanities and Social Sciences; Investigations; Kinetics; Laboratories; Lactams - chemical synthesis; Lactams - chemistry; Melanoma; Metals - chemistry; Models, Chemical; Molecular Structure; multidisciplinary; NMR; Nuclear magnetic resonance; Organic chemistry; Science; Science (multidisciplinary); Stereoisomerism; Stereoselectivity; Substrates

Rearrangement reactions have attracted considerable interest over the past decades due to their high bond-forming efficiency and atom economy in the construction of complex organic architectures. In contrast to the well-established [3,3]-rearrangement, [1,3] O-to-C rearrangement has been far less vi...