Role of neuroinflammation mediated potential alterations in adult neurogenesis as a factor for neuropsychiatric symptoms in Post-Acute COVID-19 syndrome—A narrative review

• Published in: PeerJ (San Francisco, CA) Vol. 10; p. e14227
• Main Authors: Saikarthik, Jayakumar, Saraswathi, Ilango, Alarifi, Abdulaziz, Al-Atram, Abdulrahman A., Mickeymaray, Suresh, Paramasivam, Anand, Shaikh, Saleem, Jeraud, Mathew, Alothaim, Abdulaziz S.
• Format: Journal Article
• Language: English
• Published: United States PeerJ. Ltd 04.11.2022; PeerJ, Inc; PeerJ Inc
• Subjects: Acute phase proteins; Adult; Anatomy and Physiology; Anxiety; Astrocytes; Blood-brain barrier; Chemokines; Chronic illnesses; Citation management software; Cognition disorders; Cognitive ability; Coronaviruses; COVID-19; Cytokine storm; Cytokines; Cytokines - metabolism; Dementia disorders; Depression, Mental; Development and progression; Disease; Epidemics; Humans; Immune response; Immunology; Inflammation; Insomnia; Mental depression; Mental disorders; Microglia; Neurogenesis; Neurogenesis - physiology; Neuroinflammation; Neuroinflammatory Diseases; Neurology; Post traumatic stress disorder; Post-Acute COVID-19 Syndrome; Proteins; Psychiatry and Psychology; Reviews; SARS-CoV-2; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome coronavirus 2; Sleep disorders; Stress Disorders, Post-Traumatic; COVID-19; SARS-CoV-2; Post-acute COVID-19 syndrome; Neuroinflammation; Astrocyte; Cytokine storm; Neurogenesis; Microglia

Persistence of symptoms beyond the initial 3 to 4 weeks after infection is defined as post-acute COVID-19 syndrome (PACS). A wide range of neuropsychiatric symptoms like anxiety, depression, post-traumatic stress disorder, sleep disorders and cognitive disturbances have been observed in PACS. The re...