Biomechanical cues as master regulators of hematopoietic stem cell fate

• Published in: Cellular and molecular life sciences : CMLS Vol. 78; no. 16; pp. 5881 - 5902
• Main Authors: Li, Honghu, Luo, Qian, Shan, Wei, Cai, Shuyang, Tie, Ruxiu, Xu, Yulin, Lin, Yu, Qian, Pengxu, Huang, He
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2021; Springer Nature B.V
• Subjects: adhesion; adults; Animals; Biochemistry; Biomechanical Phenomena - physiology; Biomechanics; Biomedical and Life Sciences; Biomedicine; blood; Cell Biology; Cell Differentiation - physiology; Cell fate; Cellular communication; Cues; Embryos; Extracellular matrix; Extracellular Matrix - physiology; Hematopoietic stem cells; Hematopoietic Stem Cells - physiology; Humans; Life Sciences; Mechanical control; mechanical stress; Mechanotransduction; Mechanotransduction, Cellular - physiology; Microenvironments; Review; Signal Transduction - physiology; Stem cells; Stiffness; Stress, Mechanical; Mechanical forces; Cilium; Mechanosensor; Cell–cell adhesions; HSC; Cytoskeleton; Biomechanical factors

Hematopoietic stem cells (HSCs) perceive both soluble signals and biomechanical inputs from their microenvironment and cells themselves. Emerging as critical regulators of the blood program, biomechanical cues such as extracellular matrix stiffness, fluid mechanical stress, confined adhesiveness, an...