Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage
To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PG...
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| Published in | Fertility and sterility Vol. 98; no. 1; pp. 145 - 150 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.07.2012
Elsevier |
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| Abstract | To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PGS for sex-linked diseases as a control group.
Retrospective study.
IVF clinic.
Patients with previous aneuploid conception undergoing PGS.
Embryo biopsy, fluorescence in situ hybridization.
Embryo aneuploidy rates and pregnancy and implantation rates in couples with a previous aneuploidy for autosomes or sex chromosomes.
The overall rates of chromosomal abnormalities in groups with previous autosomal aneuploidy were significantly higher compared with the control group (67.8% for those whose previous aneuploidy arose after NC and 65.8% for those previously arising after ART, vs. 34.0%). No significant differences were observed in those with previous sex chromosome abnormalities compared with control subjects. Within couples with previous aneuploidies after NC, no difference existed in the incidence of chromosomal abnormalities compared with the ART groups. Clinical outcomes were better (trend) in patients with previous autosomal aneuploidy after NC.
In preimplantation embryos, the incidence of chromosomal abnormalities due to a previous aneuploid miscarriage after either NC or ART is significantly higher than in the control group. Furthermore, this incidence is higher when the previous aneuploidy was for autosomes; PGS is recommended in these couples. |
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| AbstractList | OBJECTIVE: To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PGS for sex-linked diseases as a control group. DESIGN: Retrospective study. SETTING: IVF clinic. PATIENT(S): Patients with previous aneuploid conception undergoing PGS. INTERVENTION(S): Embryo biopsy, fluorescence in situ hybridization. MAIN OUTCOME MEASURE(S): Embryo aneuploidy rates and pregnancy and implantation rates in couples with a previous aneuploidy for autosomes or sex chromosomes. RESULT(S): The overall rates of chromosomal abnormalities in groups with previous autosomal aneuploidy were significantly higher compared with the control group (67.8% for those whose previous aneuploidy arose after NC and 65.8% for those previously arising after ART, vs. 34.0%). No significant differences were observed in those with previous sex chromosome abnormalities compared with control subjects. Within couples with previous aneuploidies after NC, no difference existed in the incidence of chromosomal abnormalities compared with the ART groups. Clinical outcomes were better (trend) in patients with previous autosomal aneuploidy after NC. CONCLUSION(S): In preimplantation embryos, the incidence of chromosomal abnormalities due to a previous aneuploid miscarriage after either NC or ART is significantly higher than in the control group. Furthermore, this incidence is higher when the previous aneuploidy was for autosomes; PGS is recommended in these couples. To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PGS for sex-linked diseases as a control group. Retrospective study. IVF clinic. Patients with previous aneuploid conception undergoing PGS. Embryo biopsy, fluorescence in situ hybridization. Embryo aneuploidy rates and pregnancy and implantation rates in couples with a previous aneuploidy for autosomes or sex chromosomes. The overall rates of chromosomal abnormalities in groups with previous autosomal aneuploidy were significantly higher compared with the control group (67.8% for those whose previous aneuploidy arose after NC and 65.8% for those previously arising after ART, vs. 34.0%). No significant differences were observed in those with previous sex chromosome abnormalities compared with control subjects. Within couples with previous aneuploidies after NC, no difference existed in the incidence of chromosomal abnormalities compared with the ART groups. Clinical outcomes were better (trend) in patients with previous autosomal aneuploidy after NC. In preimplantation embryos, the incidence of chromosomal abnormalities due to a previous aneuploid miscarriage after either NC or ART is significantly higher than in the control group. Furthermore, this incidence is higher when the previous aneuploidy was for autosomes; PGS is recommended in these couples. To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PGS for sex-linked diseases as a control group.OBJECTIVETo compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous aneuploid miscarriage after either natural conception (NC) or assisted reproductive technology (ART) versus fertile couples who underwent PGS for sex-linked diseases as a control group.Retrospective study.DESIGNRetrospective study.IVF clinic.SETTINGIVF clinic.Patients with previous aneuploid conception undergoing PGS.PATIENT(S)Patients with previous aneuploid conception undergoing PGS.Embryo biopsy, fluorescence in situ hybridization.INTERVENTION(S)Embryo biopsy, fluorescence in situ hybridization.Embryo aneuploidy rates and pregnancy and implantation rates in couples with a previous aneuploidy for autosomes or sex chromosomes.MAIN OUTCOME MEASURE(S)Embryo aneuploidy rates and pregnancy and implantation rates in couples with a previous aneuploidy for autosomes or sex chromosomes.The overall rates of chromosomal abnormalities in groups with previous autosomal aneuploidy were significantly higher compared with the control group (67.8% for those whose previous aneuploidy arose after NC and 65.8% for those previously arising after ART, vs. 34.0%). No significant differences were observed in those with previous sex chromosome abnormalities compared with control subjects. Within couples with previous aneuploidies after NC, no difference existed in the incidence of chromosomal abnormalities compared with the ART groups. Clinical outcomes were better (trend) in patients with previous autosomal aneuploidy after NC.RESULT(S)The overall rates of chromosomal abnormalities in groups with previous autosomal aneuploidy were significantly higher compared with the control group (67.8% for those whose previous aneuploidy arose after NC and 65.8% for those previously arising after ART, vs. 34.0%). No significant differences were observed in those with previous sex chromosome abnormalities compared with control subjects. Within couples with previous aneuploidies after NC, no difference existed in the incidence of chromosomal abnormalities compared with the ART groups. Clinical outcomes were better (trend) in patients with previous autosomal aneuploidy after NC.In preimplantation embryos, the incidence of chromosomal abnormalities due to a previous aneuploid miscarriage after either NC or ART is significantly higher than in the control group. Furthermore, this incidence is higher when the previous aneuploidy was for autosomes; PGS is recommended in these couples.CONCLUSION(S)In preimplantation embryos, the incidence of chromosomal abnormalities due to a previous aneuploid miscarriage after either NC or ART is significantly higher than in the control group. Furthermore, this incidence is higher when the previous aneuploidy was for autosomes; PGS is recommended in these couples. |
| Author | Pellicer, Antonio Simón, Carlos Vera, María Remohí, José Peinado, Vanessa Rubio, Carmen Al-Asmar, Nasser Hassold, Terry |
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| Copyright | 2012 American Society for Reproductive Medicine American Society for Reproductive Medicine 2015 INIST-CNRS Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
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| Keywords | fluorescence in situ hybridization assisted reproductive technology chromosomal abnormalities natural conceptions Preimplantation genetic screening Embryo Pregnancy disorders Gynecology Couple Assisted procreation Medical screening Abortion Obstetrics Technology Fluorescence in situ hybridization Genetics Molecular biology |
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| Snippet | To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS) after previous... Objective To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS)... OBJECTIVE: To compare the incidence of chromosomal abnormalities in preimplantation embryos from couples undergoing preimplantation genetic screening (PGS)... |
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| SubjectTerms | abortion (animals) Abortion, Spontaneous - epidemiology Abortion, Spontaneous - etiology Abortion, Spontaneous - genetics Abortion, Spontaneous - pathology Adult Algorithms Aneuploidy assisted reproductive technology autosomes Biological and medical sciences biopsy Birth control Cells, Cultured chromosomal abnormalities Chromosome Aberrations - statistics & numerical data conception Diseases of mother, fetus and pregnancy Embryo Culture Techniques Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Family Characteristics Female Fertilization in Vitro fluorescence in situ hybridization Gynecology. Andrology. Obstetrics Humans In Situ Hybridization, Fluorescence in vitro fertilization Infertility - epidemiology Infertility - genetics Infertility - therapy Internal Medicine Male Medical sciences natural conceptions Obstetrics and Gynecology patients Pregnancy pregnancy rate Pregnancy. Fetus. Placenta Preimplantation genetic screening Retrospective Studies screening Semen Analysis sex chromosomes Sterility. Assisted procreation |
| Title | Chromosomal abnormalities in embryos from couples with a previous aneuploid miscarriage |
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