MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response

• Published in: Cell reports (Cambridge) Vol. 2; no. 6; pp. 1657 - 1669
• Main Authors: Li, Da-Qiang, Nair, Sujit S., Ohshiro, Kazufumi, Kumar, Anupam, Nair, Vasudha S., Pakala, Suresh B., Reddy, Sirigiri Divijendra Natha, Gajula, Rajendra P., Eswaran, Jeyanthy, Aravind, L., Kumar, Rakesh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.12.2012; Elsevier
• Subjects: Adenosine Triphosphatases - genetics; Adenosine Triphosphatases - metabolism; Adenosinetriphosphatase; Amino Acid Substitution; Chromatin Assembly and Disassembly; DNA Damage; DNA Repair - genetics; HeLa Cells; Humans; Mutation, Missense; p21-Activated Kinases - genetics; p21-Activated Kinases - metabolism; Phosphorylation - genetics; Protein Structure, Tertiary; Transcription Factors - genetics; Transcription Factors - metabolism

Chromatin dynamics play a central role in maintaining genome integrity, but how this is achieved remains largely unknown. Here, we report that microrchidia CW-type zinc finger 2 (MORC2), an uncharacterized protein with a derived PHD finger domain and a conserved GHKL-type ATPase module, is a physiol...