Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein Locus
The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-specific expression profiles and putative proteolytic functions. The kallikrein family is also emerging as a rich source of disease biomarkers with KLK3, commonly known as prostate-specific antigen, being the...
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Published in | Endocrine reviews Vol. 31; no. 4; pp. 407 - 446 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Endocrine Society
01.08.2010
Oxford University Press Copyright by The Endocrine Society |
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Online Access | Get full text |
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Abstract | The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-specific expression profiles and putative proteolytic functions. The kallikrein family is also emerging as a rich source of disease biomarkers with KLK3, commonly known as prostate-specific antigen, being the current serum biomarker for prostate cancer. The kallikrein locus is also notable because it is extraordinarily responsive to steroids and other hormones. Indeed, at least 14 functional hormone response elements have been identified in the kallikrein locus. A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their effectiveness as biomarkers. In this review, we describe the organization of the kallikrein locus and the structure of kallikrein genes and proteins. We also focus on the transcriptional regulation of kallikreins by androgens, progestins, glucocorticoids, mineralocorticoids, estrogens, and other hormones in animal models and human prostate, breast, and reproductive tract tissues. The interaction of the androgen receptor with androgen response elements in the promoter and enhancer of KLK2 and KLK3 is also summarized in detail. There is evidence that all kallikreins are regulated by multiple nuclear receptors. Yet, apart from KLK2 and KLK3, it is not clear whether all kallikreins are direct transcriptional targets. Therefore, we argue that gaining more detailed information about the mechanisms that regulate kallikrein expression should be a priority of future studies and that the kallikrein locus will continue to be an important model in the era of genome-wide analyses. |
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AbstractList | The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-specific expression profiles and putative proteolytic functions. The kallikrein family is also emerging as a rich source of disease biomarkers with KLK3, commonly known as prostate-specific antigen, being the current serum biomarker for prostate cancer. The kallikrein locus is also notable because it is extraordinarily responsive to steroids and other hormones. Indeed, at least 14 functional hormone response elements have been identified in the kallikrein locus. A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their effectiveness as biomarkers. In this review, we describe the organization of the kallikrein locus and the structure of kallikrein genes and proteins. We also focus on the transcriptional regulation of kallikreins by androgens, progestins, glucocorticoids, mineralocorticoids, estrogens, and other hormones in animal models and human prostate, breast, and reproductive tract tissues. The interaction of the androgen receptor with androgen response elements in the promoter and enhancer of KLK2 and KLK3 is also summarized in detail. There is evidence that all kallikreins are regulated by multiple nuclear receptors. Yet, apart from KLK2 and KLK3, it is not clear whether all kallikreins are direct transcriptional targets. Therefore, we argue that gaining more detailed information about the mechanisms that regulate kallikrein expression should be a priority of future studies and that the kallikrein locus will continue to be an important model in the era of genome-wide analyses.
Kallikrein-related serine peptidases have diverse tissue- and disease-specific expression profiles and proteolytic functions. A prominent member of the kallikrein family, prostate-specific antigen, is the current serum biomarker for prostate cancer and is commonly used as a model target gene to study the actions of the androgen receptor. This review focuses on the regulation of kallikrein gene expression by steroid hormone receptors and other nuclear receptors as well as the structure, evolution and proteolytic functions of the kallikrein family. The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-specific expression profiles and putative proteolytic functions. The kallikrein family is also emerging as a rich source of disease biomarkers with KLK3, commonly known as prostate-specific antigen, being the current serum biomarker for prostate cancer. The kallikrein locus is also notable because it is extraordinarily responsive to steroids and other hormones. Indeed, at least 14 functional hormone response elements have been identified in the kallikrein locus. A more comprehensive understanding of the transcriptional regulation of kallikreins may help the field make more informed hypotheses about the physiological functions of kallikreins and their effectiveness as biomarkers. In this review, we describe the organization of the kallikrein locus and the structure of kallikrein genes and proteins. We also focus on the transcriptional regulation of kallikreins by androgens, progestins, glucocorticoids, mineralocorticoids, estrogens, and other hormones in animal models and human prostate, breast, and reproductive tract tissues. The interaction of the androgen receptor with androgen response elements in the promoter and enhancer of KLK2 and KLK3 is also summarized in detail. There is evidence that all kallikreins are regulated by multiple nuclear receptors. Yet, apart from KLK2 and KLK3, it is not clear whether all kallikreins are direct transcriptional targets. Therefore, we argue that gaining more detailed information about the mechanisms that regulate kallikrein expression should be a priority of future studies and that the kallikrein locus will continue to be an important model in the era of genome-wide analyses. |
Author | Lawrence, Mitchell G Clements, Judith A Lai, John |
AuthorAffiliation | Australian Prostate Cancer Research Centre-Queensland and the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4059, Australia; and the Australian Prostate Cancer BioResource, Adelaide 5000, Australia |
AuthorAffiliation_xml | – name: Australian Prostate Cancer Research Centre-Queensland and the Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane 4059, Australia; and the Australian Prostate Cancer BioResource, Adelaide 5000, Australia |
Author_xml | – sequence: 1 givenname: Mitchell G surname: Lawrence fullname: Lawrence, Mitchell G – sequence: 2 givenname: John surname: Lai fullname: Lai, John – sequence: 3 givenname: Judith A surname: Clements fullname: Clements, Judith A |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23277085$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20103546$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Androgen receptors Androgens Androgens - pharmacology Animal models Animals Antigens Biological and medical sciences Biomarkers Biomarkers, Tumor - blood Breast - chemistry Chromosomes, Human, Pair 19 Estrogens Estrogens - pharmacology Evolution, Molecular Female Functional morphology Functionals Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Gene regulation Genetic Loci - genetics Glucocorticoids Glucocorticoids - pharmacology Hormones Hormones - pharmacology Humans Kallikrein gene Kallikreins Kallikreins - chemistry Kallikreins - genetics Kallikreins - physiology Loci Male Mineralocorticoids Models, Molecular Molecular Structure Nuclear receptors Polymorphism, Genetic Progestin Progestins - pharmacology Promoter Regions, Genetic - genetics Prostate Prostate - chemistry Prostate cancer Prostate-specific antigen Prostate-Specific Antigen - chemistry Prostate-Specific Antigen - genetics Prostate-Specific Antigen - physiology Prostatic Neoplasms - blood Proteolysis Receptors Regulatory sequences Reproductive system Serine peptidase Steroid hormones Steroids Structure-function relationships Transcription Vertebrates: endocrinology |
Title | Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein Locus |
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