Effect of 6-Month Calorie Restriction and Exercise on Serum and Liver Lipids and Markers of Liver Function

• Published in: Obesity (Silver Spring, Md.) Vol. 16; no. 6; pp. 1355 - 1362
• Main Authors: Larson-Meyer, D. Enette, Newcomer, Bradley R, Heilbronn, Leonie K, Volaufova, Julia, Smith, Steven R, Alfonso, Anthony J, Lefevre, Michael, Rood, Jennifer C, Williamson, Donald A, Ravussin, Eric
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2008
• Subjects: Adult; alanine transaminase; Alanine Transaminase - metabolism; alkaline phosphatase; Alkaline Phosphatase - metabolism; biomarkers; blood; blood lipids; C-reactive protein; C-Reactive Protein - metabolism; Caloric Restriction; Cholesterol, HDL; Cholesterol, HDL - blood; Combined Modality Therapy; Cross-Sectional Studies; dieting; enzymology; exercise; Exercise - physiology; fatty liver; Female; high density lipoprotein; Humans; inflammation; Inflammation - blood; Insulin Resistance; Insulin Resistance - physiology; interleukin-6; Interleukin-6 - blood; Intervention; Lipids; Lipids - blood; liver; Liver - enzymology; Liver - physiology; liver function; Male; metabolism; Middle Aged; Obesity; overweight; Overweight - metabolism; Overweight - physiopathology; Overweight - therapy; physiology; physiopathology; Pilot Projects; therapy; triacylglycerols; Triglycerides; Triglycerides - blood; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; very low calorie diet; weight loss; Louisiana; United States > US; Utah

Objective: Nonalcoholic fatty liver disease (NAFLD) and its association with insulin resistance are increasingly recognized as major health burdens. The main objectives of this study were to assess the relation between liver lipid content and serum lipids, markers of liver function and inflammation...