Evaluation of the variability and safety of serum trough concentrations of vancomycin in patients admitted to the intensive care unit

• Published in: International journal of infectious diseases Vol. 60; no. C; pp. 17 - 22
• Main Authors: Qian, Xiaodan, Du, Guantao, Weng, Chunmei, Zhou, Haijun, Zhou, Xianju
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.07.2017; Elsevier
• Subjects: Adult; Age; Aged; Aged, 80 and over; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Body Weight; China; Critical Care; Drug Monitoring; Female; Glomerular Filtration Rate; Hospitalization; Hospitals; Humans; Incidence; Infectious Disease; Intensive Care Units; Kidney - drug effects; Male; Middle Aged; Pulmonary/Respiratory; Renal function; Retrospective Studies; Safety; Serum trough concentration; Sex; Vancomycin; Vancomycin - blood; Vancomycin - pharmacokinetics; Vancomycin - therapeutic use; Renal function; Vancomycin; Serum trough concentration; Age; Sex; vancomycin; renal function; gender; serum trough concentration; age

•The vancomycin trough concentration varies significantly in intensive care unit (ICU) patients.•Sex, age, and the estimated glomerular filtration rate are independent factors affecting the trough concentration.•The fixed-dose regimen of 2g/day may be inappropriate in ICU patients.•The dose should b...