Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

• Published in: Oncogene Vol. 22; no. 47; pp. 7340 - 7358
• Main Authors: Doyle, L Austin, Ross, Douglas D
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 20.10.2003
• Subjects: Animals; Anthracycline; Antineoplastic Agents - pharmacology; Antineoplastic drugs; Antitumor agents; ATP; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - chemistry; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; BCRP protein; Breast cancer; Breast carcinoma; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Camptothecin; Chromosome 4; DNA topoisomerase; Drug resistance; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endothelium; ErbB-1 protein; Flavopiridol; Gene Expression Regulation, Neoplastic; Gene mapping; Humans; Localization; Methotrexate; Mitoxantrone; mRNA; Multidrug resistance; Multidrug resistant organisms; Neoplasm Proteins - chemistry; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; P-Glycoprotein; Phenotypes; Proteins; Stem cells; Substrate Specificity; Transfection; Tumor cell lines

Observations of functional adenosine triphosphate (ATP)-dependent drug efflux in certain multidrug-resistant cancer cell lines without overexpression of P-glycoprotein or multidrug resistance protein (MRP) family members suggested the existence of another ATP-binding cassette (ABC) transporter capab...