Combined genetic-pharmacologic inactivation of tightly linked ADAMTS proteases in temporally specific windows uncovers distinct roles for versican proteolysis and glypican-6 in cardiac development - Mead, Timothy J.; Bhutada, Sumit; Foulcer, Simon J.; Peruzzi, Niccolò; Nelson, Courtney M.; Seifert, Deborah E.; Larkin, Jonathan; Tran-Lundmark, Karin; Filmus, Jorge; Apte, Suneel S. (Matrix biology, 2024)
Keywords: ADAMTS1 Protein - genetics; ADAMTS1 Protein - metabolism; ADAMTS5 Protein - genetics; ADAMTS5 Protein - metabolism; Animals; Degradomics; Gene Expression Regulation, Developmental; Glypican; Glypicans - genetics; Glypicans - metabolism; Heart - growth & development; Heart Defects, Congenital - genetics; Heart Defects, Congenital - metabolism; Heart Defects, Congenital - pathology; Medical and Health Sciences; Medical Biotechnology; Medicin och hälsovetenskap; Medicinsk bioteknologi; Metalloprotease; Mice; Mice, Knockout; Proteoglycan; Proteolysis; Terminomics; Versican; Versicans - genetics; Versicans - metabolism; Proteoglycan; Metalloprotease; Glypican; Terminomics; Degradomics; Versican