Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans

• Published in: BMC complementary and alternative medicine Vol. 23; no. 1; pp. 1 - 386
• Main Authors: Wu, Meng-chen, Gao, Ye-hui, Zhang, Chen, Ma, Bo-tian, Lin, Hong-ru, Jiang, Jin-yun, Xue, Meng-fan, Li, Shan, Wang, Hong-bing
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 27.10.2023; BioMed Central; BMC
• Subjects: Acetylcholinesterase; Alkaloids; Alzheimer's disease; Amyloid beta-protein; Amyloid precursor protein; Autophagy; Biocompatibility; Biotechnology; Bisbenzylisoquinoline; Caenorhabditis elegans; Chemotaxis; E coli; Enzymes; Gene expression; Genetic research; Health aspects; In vivo methods and tests; Liensinine; Mutation; Neferine; Nematoda; Nematodes; Neuroblasts; Neurodegenerative diseases; Neuroprotection; Phagosomes; Proteins; Seeds; Tau protein; Toxicity; β-Amyloid; Sweden; China; Minneapolis Minnesota; United States > US

Background Liensinine and neferine are the main bisbenzylisoquinoline alkaloids obtained from the seeds of Nelumbo nucifera, which commonly used as edible food and traditional medicine in Asia. It was reported that liensinine and neferine could inhibit the activities of acetylcholinesterase and cros...