Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis

• Published in: Cancer research (Chicago, Ill.) Vol. 77; no. 10; pp. 2620 - 2632
• Main Authors: Tomkovich, Sarah, Yang, Ye, Winglee, Kathryn, Gauthier, Josee, Mühlbauer, Marcus, Sun, Xiaolun, Mohamadzadeh, Mansour, Liu, Xiuli, Martin, Patricia, Wang, Gary P., Oswald, Eric, Fodor, Anthony A., Jobin, Christian
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research, Inc 15.05.2017; American Association for Cancer Research
• Subjects: Adenomatous Polyposis Coli Protein - deficiency; Adhesins; Age; Animals; Bacteria - classification; Bacteria - genetics; Cancer; Carcinogenesis; Cell Transformation, Neoplastic; Clinical isolates; Colon; Colon cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - etiology; Colorectal Neoplasms - pathology; Disease Models, Animal; Etiology; Fusobacterium nucleatum; Gastrointestinal Microbiome; Germfree; Gnotobiotic; Human health and pathology; Hépatology and Gastroenterology; Inflammation; Inflammation - complications; Inflammation - pathology; Interleukin 1; Interleukin 10; Interleukin-10 - deficiency; Large intestine; Life Sciences; Mice; Mice, Knockout; Mice, Transgenic; Microbiomes; Microbiota; Small intestine; Specific pathogen free; Tumorigenesis; cancer du colon; colon cancer; microbiote digestif; inflammation du colon

Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect how the microbiota contributes to tumor distribution, we generated germ-free (GF) ApcMin/+and ApcMin/+;Il10−/− mice and exposed them to specific-pathogen-free (SPF) or colorectal cancer-associated bacteria. W...