Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers： challenges and opportunities

• Published in: Acta pharmacologica Sinica Vol. 38; no. 6; pp. 782 - 797
• Main Authors: Mangal, Sharad, Gao, Wei, Li, Tonglei, Zhou, Qi (Tony)
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2017; Nature Publishing Group
• Subjects: Administration, Inhalation; Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Biomedicine; Drug Carriers - chemistry; Drug Delivery Systems; Humans; Immunology; Internal Medicine; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Medical Microbiology; Nanoparticles - chemistry; Nanoparticles - metabolism; Nanoparticles - therapeutic use; Pharmacology/Toxicology; Review; Vaccine; 化疗药物; 应用; 抗癌药物; 治疗; 纳米颗粒; 肺动脉; 肺癌; 肿瘤生长

Lung cancer is the second most prevalent and the deadliest among all cancer types. Chemotherapy is recommended for lung cancers to control tumor growth and to prolong patient survival. Systemic chemotherapy typically has very limited efficacy as well as severe systemic adverse effects, which are oft...